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Arshak R. Alexanian VMD, PhD

Arshak R. Alexanian VMD, PhD profile photo picture

Adjunct Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine

Member of the Cardiovascular Center

View Curriculum Vitae

Publications (27)

  • Epigenetic modifiers either individually or in specific combinations impair viability of patient-derived glioblastoma cell line while exhibit moderate effect on normal stem cells growth. (Alexanian AR, Stoellinger HM, de Araujo Farias V, Quiñones-Hinojosa A) Invest New Drugs 2023 Jun;41(3):371-375 PMID: 37162706 SCOPUS ID: 2-s2.0-85159057269 05/10/2023    
  • Combination of the modulators of epigenetic machinery and specific cell signaling pathways as a promising approach for cell reprogramming. (Alexanian AR) Mol Cell Biochem 2022 Oct;477(10):2309-2317 PMID: 35503191 SCOPUS ID: 2-s2.0-85129288656 05/04/2022    
  • Unique combinations of epigenetic modifiers synergistically impair the viability of the U87 glioblastoma cell line while exhibiting minor or moderate effects on normal stem cell growth. (Alexanian AR, Brannon A) Med Oncol 2022 Apr 28;39(5):86 PMID: 35478054 SCOPUS ID: 2-s2.0-85128910699 04/29/2022       3 Citations
  • Modifications to the Transwell Migration/Invasion Assay Method That Eases Assay Performance and Improves the Accuracy. (Stoellinger HM, Alexanian AR) Assay Drug Dev Technol 2022;20(2):75-82 PMID: 35196113 PMCID: PMC8968842 SCOPUS ID: 2-s2.0-85126072900 02/24/2022       9 Citations
  • Specific combinations of the chromatin-modifying enzyme modulators significantly attenuate glioblastoma cell proliferation and viability while exerting minimal effect on normal adult stem cells growth. (Alexanian AR, Huang YW) Tumour Biol 2015 Nov;36(11):9067-72 PMID: 26084611 SCOPUS ID: 2-s2.0-84949109374 06/19/2015       4 Citations
  • Epigenetic modulators promote mesenchymal stem cell phenotype switches. (Alexanian AR) Int J Biochem Cell Biol 2015 Jul;64:190-4 PMID: 25936755 SCOPUS ID: 2-s2.0-84928947042 05/06/2015       12 Citations
  • Enhanced dopamine release by mesenchymal stem cells reprogrammed neuronally by the modulators of SMAD signaling, chromatin modifying enzymes, and cyclic adenosine monophosphate levels. (Funk RT, Alexanian AR) Transl Res 2013 Nov;162(5):317-23 PMID: 24001408 SCOPUS ID: 2-s2.0-84886102303 09/05/2013       5 Citations
  • Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels. (Alexanian AR, Liu QS, Zhang Z) Int J Biochem Cell Biol 2013 Aug;45(8):1633-8 PMID: 23665234 SCOPUS ID: 2-s2.0-84884848438 05/15/2013       21 Citations
  • Dopaminergic-like cells from epigenetically reprogrammed mesenchymal stem cells. (Zhang Z, Alexanian AR) J Cell Mol Med 2012 Nov;16(11):2708-14 PMID: 22681532 PMCID: PMC4118239 SCOPUS ID: 2-s2.0-84868133333 06/12/2012       10 Citations
  • The neural plasticity of early-passage human bone marrow-derived mesenchymal stem cells and their modulation with chromatin-modifying agents. (Zhang Z, Alexanian AR) J Tissue Eng Regen Med 2014 May;8(5):407-13 PMID: 22674835 SCOPUS ID: 2-s2.0-84898480303 06/08/2012       10 Citations
  • Transplanted neurally modified bone marrow-derived mesenchymal stem cells promote tissue protection and locomotor recovery in spinal cord injured rats. (Alexanian AR, Fehlings MG, Zhang Z, Maiman DJ) Neurorehabil Neural Repair 2011;25(9):873-80 PMID: 21844281 SCOPUS ID: 2-s2.0-80054030150 08/17/2011       50 Citations
  • Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors. (Zhang Z, Maiman DJ, Kurpad SN, Crowe MJ, Alexanian AR) Cell Reprogram 2011 Oct;13(5):385-90 PMID: 21718099 SCOPUS ID: 2-s2.0-80053554317 07/02/2011       12 Citations
  • Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats. (Alexanian AR, Kwok WM, Pravdic D, Maiman DJ, Fehlings MG) Restor Neurol Neurosci 2010;28(6):761-7 PMID: 21209491 SCOPUS ID: 2-s2.0-78650261810 01/07/2011       22 Citations
  • An efficient method for generation of neural-like cells from adult human bone marrow-derived mesenchymal stem cells. (Alexanian AR) Regen Med 2010 Nov;5(6):891-900 PMID: 21082889 SCOPUS ID: 2-s2.0-78649352249 11/19/2010       29 Citations
  • Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. (Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN) Cytotherapy 2011 Jan;13(1):61-8 PMID: 20735167 SCOPUS ID: 2-s2.0-78650324250 08/26/2010       29 Citations
  • In vitro and in vivo characterization of neurally modified mesenchymal stem cells induced by epigenetic modifiers and neural stem cell environment. (Alexanian AR, Maiman DJ, Kurpad SN, Gennarelli TA) Stem Cells Dev 2008 Dec;17(6):1123-30 PMID: 18484898 SCOPUS ID: 2-s2.0-57449101862 05/20/2008       73 Citations
  • Epigenetic modifiers promote efficient generation of neural-like cells from bone marrow-derived mesenchymal cells grown in neural environment. (Alexanian AR) J Cell Biochem 2007 Feb 01;100(2):362-71 PMID: 16924670 SCOPUS ID: 2-s2.0-33846428781 08/23/2006       47 Citations
  • Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. (Macias MY, Syring MB, Pizzi MA, Crowe MJ, Alexanian AR, Kurpad SN) Exp Neurol 2006 Oct;201(2):335-48 PMID: 16839548 SCOPUS ID: 2-s2.0-33748426473 07/15/2006       126 Citations
  • Neural stem cells induce bone-marrow-derived mesenchymal stem cells to generate neural stem-like cells via juxtacrine and paracrine interactions. (Alexanian AR) Exp Cell Res 2005 Nov 01;310(2):383-91 PMID: 16168985 SCOPUS ID: 2-s2.0-26844431677 09/20/2005       47 Citations
  • Efficient differentiation and integration of lineage-restricted neural precursors in the traumatically injured adult cat spinal cord. (Alexanian AR, Crowe MJ, Kurpad SN) J Neurosci Methods 2006 Jan 15;150(1):41-6 PMID: 16087243 SCOPUS ID: 2-s2.0-28844494926 08/10/2005       19 Citations
  • Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture. (Alexanian AR, Kurpad SN) Exp Neurol 2005 Jan;191(1):193-7 PMID: 15589526 SCOPUS ID: 2-s2.0-10044251181 12/14/2004       21 Citations
  • Differentiating adult hippocampal stem cells into neural crest derivatives. (Alexanian AR, Sieber-Blum M) Neuroscience 2003;118(1):1-5 PMID: 12676130 SCOPUS ID: 2-s2.0-0037466241 04/05/2003       28 Citations
  • Calcium-dependent regulation of interactions of caldesmon with calcium-binding proteins found in growth cones of chick forebrain neurons. (Alexanian AR, Bamburg JR, Hidaka H, Mornet D) Cell Mol Neurobiol 2001 Oct;21(5):437-51 PMID: 11860183 SCOPUS ID: 2-s2.0-0035716362 02/28/2002       3 Citations
  • Proliferation and regeneration of retrogradely labeled adult rat corticospinal neurons in culture. (Alexanian AR, Nornes HO) Exp Neurol 2001 Aug;170(2):277-82 PMID: 11476593 SCOPUS ID: 2-s2.0-0034869214 07/31/2001       12 Citations
  • Reversal of drug resistance in sarcoma-45 by the new calmodulin antagonist--trihydrochloride of [1,2,5-trimethyl-4-phenyl-4-beta-[N-(beta-ethylamino)-N-4'-methoxybe nzy l]-ethylamino] piperidine (AR-2). (Alexanian AR, Arutyunian NS) Invest New Drugs 1999;17(2):105-10 PMID: 10638481 SCOPUS ID: 2-s2.0-0032805142 01/19/2000       3 Citations
  • Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. (Alexanian AR, Bamburg JR) FASEB J 1999 Sep;13(12):1611-20 PMID: 10463953 SCOPUS ID: 2-s2.0-0032851616 08/27/1999       50 Citations
  • Antiarrhythmic action of the new calcium antagonist [1,2,5-trimethyl-4-phenyl-4-beta-(N-cyanoethyl-N-4'-methoxybenzyl) -ethylamino]piperidine dihydrochloride. (Alexanian AR, Arutyunian NS, Galoyan AA) Arzneimittelforschung 1996 Dec;46(12):1110-3 PMID: 9006783 SCOPUS ID: 2-s2.0-0030480339 12/01/1996       3 Citations
    • Last update: 05/07/2024