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Gang Cheng PhD
Assistant Professor
Institution:
Medical College of Wisconsin
Department:
Biophysics
Program:
Research
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Publications (47)
The role of short-chain fatty acids in cancer prevention and cancer treatment.
(Kalyanaraman B, Cheng G, Hardy M)
Arch Biochem Biophys
2024 Nov;761:110172 PMID: 39369836 PMCID: PMC11784870 SCOPUS ID: 2-s2.0-85205522642 10/07/2024
6 Citations
Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson's disease.
(Cheng G, Hardy M, Hillard CJ, Feix JB, Kalyanaraman B)
Commun Biol
2024 May 30;7(1):668 PMID: 38816577 PMCID: PMC11139878 SCOPUS ID: 2-s2.0-85194991828 05/31/2024
1 Citation
Characterizing OXPHOS inhibitor-mediated alleviation of hypoxia using high-throughput live cell-imaging.
(Beerkens APM, Boreel DF, Nathan JA, Neuzil J, Cheng G, Kalyanaraman B, Hardy M, Adema GJ, Heskamp S, Span PN, Bussink J)
Cancer Metab
2024 May 03;12(1):13 PMID: 38702787 PMCID: PMC11067257 05/04/2024
Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications.
(Kalyanaraman B, Cheng G, Hardy M)
Redox Biol
2024 May;71:103092 PMID: 38377788 PMCID: PMC10891329 SCOPUS ID: 2-s2.0-85185575430 02/21/2024
25 Citations
OXPHOS-targeting drugs in oncology: new perspectives.
(Kalyanaraman B, Cheng G, Hardy M, You M)
Expert Opin Ther Targets
2023;27(10):939-952 PMID: 37736880 PMCID: PMC11034819 SCOPUS ID: 2-s2.0-85173986031 09/22/2023
19 Citations
Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies.
(Cheng G, Karoui H, Hardy M, Kalyanaraman B)
Free Radic Biol Med
2023 Aug 20;205:175-187 PMID: 37321281 PMCID: PMC11129726 SCOPUS ID: 2-s2.0-85162228734 06/16/2023
2 Citations
Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells.
(Cheng G, Hardy M, Kalyanaraman B)
Sci Rep
2023 May 04;13(1):7254 PMID: 37142668 PMCID: PMC10160116 SCOPUS ID: 2-s2.0-85158068757 05/05/2023
3 Citations
Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment.
(Cheng G, Karoui H, Hardy M, Kalyanaraman B)
Cancers (Basel)
2023 Feb 08;15(4) PMID: 36831432 PMCID: PMC9953882 SCOPUS ID: 2-s2.0-85149107017 02/26/2023
1 Citation
Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities.
(Kalyanaraman B, Cheng G, Hardy M)
Front Oncol
2022;12:816504 PMID: 35756631 PMCID: PMC9214210 SCOPUS ID: 2-s2.0-85133350425 06/28/2022
13 Citations
Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation.
(Cheng G, Hardy M, You M, Kalyanaraman B)
Sci Rep
2022 Mar 24;12(1):5143 PMID: 35332210 PMCID: PMC8948292 SCOPUS ID: 2-s2.0-85127039662 03/26/2022
10 Citations
Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects.
(Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B)
iScience
2021 Jun 25;24(6):102673 PMID: 34189437 PMCID: PMC8215227 SCOPUS ID: 2-s2.0-85107809306 07/01/2021
20 Citations
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
(AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB)
iScience
2021 Jun 25;24(6):102653 PMID: 34189432 PMCID: PMC8220235 SCOPUS ID: 2-s2.0-85107963806 07/01/2021
20 Citations
Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone.
(Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B)
Sci Rep
2020 Oct 21;10(1):17872 PMID: 33087770 PMCID: PMC7578061 SCOPUS ID: 2-s2.0-85093870747 10/23/2020
33 Citations
Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells.
(Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B)
Cancer Treat Res Commun
2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020
27 Citations
Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.
(Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M)
Cell Commun Signal
2020 Apr 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020
25 Citations
Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.
(Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B)
Free Radic Biol Med
2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019
17 Citations
Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators.
(Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B)
Oncotarget
2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 SCOPUS ID: 2-s2.0-85089087803 06/14/2019
17 Citations
High-Throughput Screening of NOX Inhibitors.
(Zielonka J, Zielonka M, Cheng G, Hardy M, Kalyanaraman B)
Methods Mol Biol
2019;1982:429-446 PMID: 31172487 PMCID: PMC6953630 SCOPUS ID: 2-s2.0-85067079084 06/07/2019
12 Citations
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis.
(Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M)
Nat Commun
2019 May 17;10(1):2205 PMID: 31101821 PMCID: PMC6525201 SCOPUS ID: 2-s2.0-85065824371 05/19/2019
181 Citations
Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity.
(Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M)
iScience
2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 SCOPUS ID: 2-s2.0-85063413951 11/15/2018
45 Citations
Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies.
(Kalyanaraman B, Cheng G, Zielonka J, Bennett B)
Cell Biochem Biophys
2019 Mar;77(1):89-98 PMID: 30259334 PMCID: PMC6430651 SCOPUS ID: 2-s2.0-85054023520 09/28/2018
13 Citations
Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation.
(Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB)
J Biol Chem
2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018
115 Citations
Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future.
(Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B)
J Biol Chem
2018 Jun 29;293(26):10363-10380 PMID: 29739855 PMCID: PMC6028982 SCOPUS ID: 2-s2.0-85049623107 05/10/2018
81 Citations
Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327].
(Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB)
Redox Biol
2018 Jun;16:426-427 PMID: 29548725 PMCID: PMC5952812 SCOPUS ID: 2-s2.0-85043469209 03/20/2018
6 Citations
Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.
(Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J)
Redox Biol
2018 May;15:347-362 PMID: 29306792 PMCID: PMC5756055 SCOPUS ID: 2-s2.0-85039930921 01/08/2018
179 Citations
A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds.
(Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB)
Redox Biol
2018 Apr;14:316-327 PMID: 29017115 PMCID: PMC5633086 SCOPUS ID: 2-s2.0-85030681499 10/11/2017
190 Citations
Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases.
(Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B)
Cell Biochem Biophys
2017 Dec;75(3-4):335-349 PMID: 28660426 PMCID: PMC5693611 SCOPUS ID: 2-s2.0-85025160609 07/01/2017
22 Citations
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.
(Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B)
Chem Rev
2017 Aug 09;117(15):10043-10120 PMID: 28654243 PMCID: PMC5611849 SCOPUS ID: 2-s2.0-85027303022 06/28/2017
1214 Citations
Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.
(Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB)
Cell Biochem Biophys
2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 SCOPUS ID: 2-s2.0-85018513016 04/22/2017
21 Citations
Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.
(Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M)
Interface Focus
2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 SCOPUS ID: 2-s2.0-85013194895 04/07/2017
27 Citations
Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling.
(Kalyanaraman B, Hardy M, Podsiadly R, Cheng G, Zielonka J)
Arch Biochem Biophys
2017 Mar 01;617:38-47 PMID: 27590268 PMCID: PMC5318280 SCOPUS ID: 2-s2.0-84995422269 09/04/2016
113 Citations
Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells.
(Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B)
Cancer Res
2016 Jul 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 SCOPUS ID: 2-s2.0-84977588183 05/25/2016
166 Citations
Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation.
(Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadły R, Sikora A, Lambeth JD, Kalyanaraman B)
J Biol Chem
2016 Mar 25;291(13):7029-44 PMID: 26839313 PMCID: PMC4807286 SCOPUS ID: 2-s2.0-84964907042 02/04/2016
59 Citations
Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism.
(Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B)
Cancer Lett
2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 SCOPUS ID: 2-s2.0-84930823628 05/26/2015
64 Citations
Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.
(Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B)
Br J Cancer
2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 SCOPUS ID: 2-s2.0-84904114424 05/29/2014
74 Citations
High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.
(Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, Michalski R, O'Brien WJ, Lambeth JD, Kalyanaraman B)
J Biol Chem
2014 Jun 06;289(23):16176-89 PMID: 24764302 PMCID: PMC4047388 SCOPUS ID: 2-s2.0-84902206908 04/26/2014
65 Citations
Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.
(Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA)
PLoS One
2013;8(8):e70575 PMID: 23940596 PMCID: PMC3734284 SCOPUS ID: 2-s2.0-84881115392 08/14/2013
60 Citations
Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma.
(Dilip A, Cheng G, Joseph J, Kunnimalaiyaan S, Kalyanaraman B, Kunnimalaiyaan M, Gamblin TC)
Anticancer Drugs
2013 Oct;24(9):881-8 PMID: 23872912 PMCID: PMC4028966 SCOPUS ID: 2-s2.0-84883451405 07/23/2013
27 Citations
Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death.
(Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B)
BMC Cancer
2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 SCOPUS ID: 2-s2.0-84878817212 06/15/2013
111 Citations
Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death.
(Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B)
Cancer Res
2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 SCOPUS ID: 2-s2.0-84861158967 03/21/2012
220 Citations
Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells.
(Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B)
Cancer Biol Ther
2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 SCOPUS ID: 2-s2.0-80054116454 07/30/2011
26 Citations
Establishment of a diabetic-hypertensive rat model
(Zhang B, Cheng G, Liu H, Wang L-L, Li S)
Journal of Shenyang Pharmaceutical University
44(6):575-80 [in Chinese] 01/01/2009
Evaluation of the cardiovascular function of older adult Rhesus monkeys by ultrasonography.
(Tang HL, Wang LL, Cheng G, Wang L, Li S)
J Med Primatol
2008 Apr;37(2):101-8 PMID: 18333921 SCOPUS ID: 2-s2.0-40749121257 03/13/2008
26 Citations
AGEs cross-links and endothelium dysfunction
(Zhang B, Cheng G, Wang L-L, Li S)
Chinese Pharmacological Bulletin
23(5):565-7 [in Chinese] 01/01/2007
Cardiovascular effects of advanced glycation endproducts breaker (C24) in diabetic rats
(Cheng G, Wang L-L, Long L, Cao Y-L, Li S)
Journal of Shenyang Pharmaceutical University
23(7):452-5 [in Chinese] 01/01/2006
C16, a novel advanced glycation endproduct breaker, restores cardiovascular dysfunction in experimental diabetic rats.
(Cheng G, Wang LL, Qu WS, Long L, Cui H, Liu HY, Cao YL, Li S)
Acta Pharmacol Sin
2005 Dec;26(12):1460-6 PMID: 16297344 SCOPUS ID: 2-s2.0-29044432819 11/22/2005
28 Citations
Effects of piracetam on the content of monoamines transmitter induced by restraint water-immersion in the rat brain
(Xu P-P, Cheng G , Zhou X-M, Ma T, Xu C, Cao Y-L, Su L)
Journal of Shenyang Pharmaceutical University
18(5):366-9 [in Chinese] 01/01/2001
Last update: 10/08/2024