Medical College of Wisconsin
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Karen A. Blindauer MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Neurology

Member of the Neuroscience Research Center
Member of the Wisconsin Institute of NeuroScience (WINS)

Publications (32)

  • The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson’s disease (Werner MH, McGarry A, Meyer C, Mancino E, Klint C, Pellecchia J, Kieburtz K, Levine T, Bellaire B, Gibbons C, Freeman R, Ellenbogen A, Klos K, Ospina M, Hauser RA, Shannon K, Asaad H, Park A, McAllister P, Isaacson SH, LeDoux MS, Dhall R, Shpiner D, Charles P, Agarwal P, Peckham E, Mazzeo P, Davis M, Pahwa R, Brodsky M, Lew M, Purino L, Mantri S, Parashos S, Justiz W, Chachar M, Robottom B, Budman E, Blindauer K, Bellows S, Goudreau J, Steen S, Olanow CW) Nature Aging March 2026;6(3):626-635 SCOPUS ID: 2-s2.0-105030609326 03/01/2026    
  • Parkinson's disease variant detection and disclosure: PD GENEration, a North American study. (Cook L, Verbrugge J, Schwantes-An TH, Schulze J, Foroud T, Hall A, Marder KS, Mata IF, Mencacci NE, Nance MA, Schwarzschild MA, Simuni T, Bressman S, Wills AM, Fernandez HH, Litvan I, Lyons KE, Shill HA, Singer C, Tropea TF, Vanegas Arroyave N, Carbonell J, Cruz Vicioso R, Katus L, Quinn JF, Hodges PD, Meng Y, Strom SP, Blauwendraat C, Lohmann K, Casaceli C, Rao SC, Ghosh Galvelis K, Naito A, Beck JC, Alcalay RN) Brain 2024 Aug 01;147(8):2668-2679 PMID: 39074992 PMCID: PMC11292896 SCOPUS ID: 2-s2.0-85200266287 07/30/2024       50 Citations
  • Consensus-Based Attributes for Identifying Patients With Spasmodic Dysphonia and Other Voice Disorders. (Ludlow CL, Domangue R, Sharma D, Jinnah HA, Perlmutter JS, Berke G, Sapienza C, Smith ME, Blumin JH, Kalata CE, Blindauer K, Johns M, Hapner E, Harmon A, Paniello R, Adler CH, Crujido L, Lott DG, Bansberg SF, Barone N, Drulia T, Stebbins G) JAMA Otolaryngol Head Neck Surg 2018 Aug 01;144(8):657-665 PMID: 29931028 PMCID: PMC6143004 SCOPUS ID: 2-s2.0-85051953234 06/23/2018       67 Citations
  • Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. (Huntington Study Group, Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, O'Neill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F Jr, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E) JAMA 2016 Jul 05;316(1):40-50 PMID: 27380342 SCOPUS ID: 2-s2.0-84977592334 07/06/2016       223 Citations
  • Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials. (Huntington Study Group PHAROS Investigators, Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, Siemers E, Tanner C, Mallonee W, Suter G, Dubinsky R, Gray C, Nance M, Bundlie S, Radtke D, Kostyk S, Baic C, Caress J, Walker F, Hunt V, O'Neill C, Chouinard S, Factor S, Greenamyre T, Wood-Siverio C, Corey-Bloom J, Song D, Peavy G, Moskowitz C, Wesson M, Samii A, Bird T, Lipe H, Blindauer K, Marshall F, Zimmerman C, Goldstein J, Rosas D, Novak P, Caviness J, Adler C, Duffy A, Wheelock V, Tempkin T, Richman D, Seeberger L, Albin R, Chou KL, Racette B, Perlmutter JS, Perlman S, Bordelon Y, Martin W, Wieler M, Leavitt B, Raymond L, Decolongon J, Clarke L, Jankovic J, Hunter C, Hauser RA, Sanchez-Ramos J, Furtado S, Suchowersky O, Klimek ML, Guttman M, Sethna R, Feigin A, Cox M, Shannon B, Percy A, Dure L, Harrison M, Johnson W, Higgins D, Molho E, Nickerson C, Evans S, Hobson D, Singer C, Galvez-Jimenez N, Shannon K, Comella C, Ross C, Saint-Hilaire MH, Testa C, Rosenblatt A, Hogarth P, Weiner W, Como P, Kumar R, Cotto C, Stout J, Brocht A, Watts A, Eberly S, Weaver C, Foroud T, Gusella J, MacDonald M, Myers R, Fahn S, Shults C) JAMA Neurol 2016 Jan;73(1):102-10 PMID: 26569098 SCOPUS ID: 2-s2.0-84954207601 11/17/2015       39 Citations
  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. (Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB) Nat Genet 2014 Sep;46(9):989-93 PMID: 25064009 PMCID: PMC4146673 SCOPUS ID: 2-s2.0-84939599004 07/30/2014       1560 Citations
  • A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. (Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, Griebner B, Watts A, Gao S, Pourcher E, Bond L, Kompoliti K, Agarwal P, Sia C, Jog M, Cole L, Sultana M, Kurlan R, Richard I, Deeley C, Waters CH, Figueroa A, Arkun A, Brodsky M, Ondo WG, Hunter CB, Jimenez-Shahed J, Palao A, Miyasaki JM, So J, Tetrud J, Reys L, Smith K, Singer C, Blenke A, Russell DS, Cotto C, Friedman JH, Lannon M, Zhang L, Drasby E, Kumar R, Subramanian T, Ford DS, Grimes DA, Cote D, Conway J, Siderowf AD, Evatt ML, Sommerfeld B, Lieberman AN, Okun MS, Rodriguez RL, Merritt S, Swartz CL, Martin WR, King P, Stover N, Guthrie S, Watts RL, Ahmed A, Fernandez HH, Winters A, Mari Z, Dawson TM, Dunlop B, Feigin AS, Shannon B, Nirenberg MJ, Ogg M, Ellias SA, Thomas CA, Frei K, Bodis-Wollner I, Glazman S, Mayer T, Hauser RA, Pahwa R, Langhammer A, Ranawaya R, Derwent L, Sethi KD, Farrow B, Prakash R, Litvan I, Robinson A, Sahay A, Gartner M, Hinson VK, Markind S, Pelikan M, Perlmutter JS, Hartlein J, Molho E, Evans S, Adler CH, Duffy A, Lind M, Elmer L, Davis K, Spears J, Wilson S, Leehey MA, Hermanowicz N, Niswonger S, Shill HA, Obradov S, Rajput A, Cowper M, Lessig S, Song D, Fontaine D, Zadikoff C, Williams K, Blindauer KA, Bergholte J, Propsom CS, Stacy MA, Field J, Mihaila D, Chilton M, Uc EY, Sieren J, Simon DK, Kraics L, Silver A, Boyd JT, Hamill RW, Ingvoldstad C, Young J, Thomas K, Kostyk SK, Wojcieszek J, Pfeiffer RF, Panisset M, Beland M, Reich SG, Cines M, Zappala N, Rivest J, Zweig R, Lumina LP, Hilliard CL, Grill S, Kellermann M, Tuite P, Rolandelli S, Kang UJ, Young J, Rao J, Cook MM, Severt L, Boyar K) JAMA Neurol 2014 May;71(5):543-52 PMID: 24664227 SCOPUS ID: 2-s2.0-84900479240 03/26/2014       377 Citations
  • Where is the action? Action sentence processing in Parkinson's disease. (Fernandino L, Conant LL, Binder JR, Blindauer K, Hiner B, Spangler K, Desai RH) Neuropsychologia 2013 Jul;51(8):1510-7 PMID: 23624313 PMCID: PMC3731159 SCOPUS ID: 2-s2.0-84879151933 04/30/2013       110 Citations
  • A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease. (HORIZON Investigators of the Huntington Study Group and European Huntington's Disease Network) JAMA Neurol 2013 Jan;70(1):25-33 PMID: 23108692 SCOPUS ID: 2-s2.0-84872512504 10/31/2012       21 Citations
  • Parkinson's disease disrupts both automatic and controlled processing of action verbs. (Fernandino L, Conant LL, Binder JR, Blindauer K, Hiner B, Spangler K, Desai RH) Brain Lang 2013 Oct;127(1):65-74 PMID: 22910144 PMCID: PMC3574625 SCOPUS ID: 2-s2.0-84880963780 08/23/2012       149 Citations
  • Atypical parkinsonism and cerebellar ataxia (Blindauer K) Movement Disorders 100 Instructive Cases 1 January 2008:61-63 SCOPUS ID: 2-s2.0-85056320369 01/01/2008    
  • R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation (Nichols WC, Marek DK, Pauciulo MW, Pankratz N, Halter CA, Rudolph A, Shults CW, Wojcieszek J, Foroud T, Shults CW, Marshall F, Oakes D, Rudolph A, Shinaman A, Marder K, Conneally PM, Halter CA, Lyons K, Siemers E, Factor S, Higgins D, Evans S, Shill H, Stacy M, Danielson J, Marlor L, Williamson K, Jankovic J, Hunter C, Simon D, Ryan P, Scollins L, Saunders-Pullman R, Boyar K, Costan-Toth C, Ohmann E, Sudarsky L, Joubert C, Friedman J, Chou K, Fernandez H, Lannon M, Galvez-Jimenez N, Podichetty A, Lewitt P, DeAngelis M, O'Brien C, Seeberger L, Dingmann C, Judd D, Marder K, Fraser J, Harris J, Bertoni J, Peterson C, Chouinard S, Panisset M, Hall J, Poiffaut H, Calabrese V, Roberge P, Wojcieszek J, Belden J, Halter C, Jennings D, Marek K, Mendick S, Reich S, Dunlop B, Jog M, Horn C, Rao J, Cook M, Uitti R, Turk M, Ajax T, Mannetter J, Panisset M, Hall J, Sethi K, Carpenter J, Ligon K, Narayan S, Woodward L, Blindauer K, Petit J, Elmer L, Aiken E, Davis K, Schell C, Wilson S, Velickovic M, Koller W, Phipps S, Feigin A, Gordon M, Hamann J, Licari E, Marotta-Kollarus M, Shannon B) Movement Disorders 15 January 2007;22(2):254-256 SCOPUS ID: 2-s2.0-33847700524 01/15/2007       7 Citations
  • Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease. (Pankratz N, Pauciulo MW, Elsaesser VE, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, Nichols WC, Parkinson Study Group-PROGENI Investigators) Mov Disord 2006 Dec;21(12):2257-60 PMID: 17078063 SCOPUS ID: 2-s2.0-33846463019 11/02/2006       30 Citations
  • Effects of tyramine administration in Parkinson's disease patients treated with selective MAO-B inhibitor rasagiline. (deMarcaida JA, Schwid SR, White WB, Blindauer K, Fahn S, Kieburtz K, Stern M, Shoulson I, Parkinson Study Group TEMPO, PRESTO Tyramine Substudy Investigators and Coordinators) Mov Disord 2006 Oct;21(10):1716-21 PMID: 16856145 SCOPUS ID: 2-s2.0-33750296512 07/21/2006       84 Citations
  • Rasagiline-associated motor improvement in PD occurs without worsening of cognitive and behavioral symptoms. (Elmer L, Schwid S, Eberly S, Goetz C, Fahn S, Kieburtz K, Oakes D, Blindauer K, Salzman P, Oren S, Prisco UL, Stern M, Shoulson I, Parkinson Study Group TEMPO, PRESTO Investigators) J Neurol Sci 2006 Oct 25;248(1-2):78-83 PMID: 16828804 SCOPUS ID: 2-s2.0-33750480538 07/11/2006       44 Citations
  • Randomized placebo-controlled study of the nicotinic agonist SIB-1508Y in Parkinson disease. (Parkinson Study Group) Neurology 2006 Feb 14;66(3):408-10 PMID: 16476941 SCOPUS ID: 2-s2.0-33646184356 02/16/2006       47 Citations
  • A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. (Blindauer K, Shoulson I, Oakes D, Kieburtz K, Schwid S, Fahn S, Stern M, Goetz C, Nutt J, Goren S, Sayag N, Scolnik M, Levy R, Eyal E, Salzman P, Pagano M, Parkinson Study Group) Arch Neurol 2006 Feb;63(2):210-6 PMID: 16476809 SCOPUS ID: 2-s2.0-32944479042 02/16/2006       32 Citations
  • Rasagiline improves quality of life in patients with early Parkinson's disease. (Biglan KM, Schwid S, Eberly S, Blindauer K, Fahn S, Goren T, Kieburtz K, Oakes D, Plumb S, Siderowf A, Stern M, Shoulson I, Parkinson Study Group) Mov Disord 2006 May;21(5):616-23 PMID: 16450340 SCOPUS ID: 2-s2.0-33744915026 02/02/2006       65 Citations
  • Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia. (Pankratz N, Byder L, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T, Nichols WC) Mov Disord 2006 Jan;21(1):45-9 PMID: 16116614 SCOPUS ID: 2-s2.0-33244482562 08/24/2005       110 Citations
  • Interrater agreement in the assessment of motor manifestations of Huntington's disease. (Hogarth P, Kayson E, Kieburtz K, Marder K, Oakes D, Rosas D, Shoulson I, Wexler NS, Young AB, Zhao H) Mov Disord 2005 Mar;20(3):293-7 PMID: 15584032 SCOPUS ID: 2-s2.0-20944438389 12/08/2004       72 Citations
  • Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. (Nichols WC, Uniacke SK, Pankratz N, Reed T, Simon DK, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T, Parkinson Study Group) Mov Disord 2004 Jun;19(6):649-55 PMID: 15197702 SCOPUS ID: 2-s2.0-3843050571 06/16/2004       33 Citations
  • Neural basis for impaired time reproduction in Parkinson's disease: an fMRI study. (Elsinger CL, Rao SM, Zimbelman JL, Reynolds NC, Blindauer KA, Hoffmann RG) J Int Neuropsychol Soc 2003 Nov;9(7):1088-98 PMID: 14738289 SCOPUS ID: 2-s2.0-0242391756 01/24/2004       97 Citations
  • A controlled trial of rotigotine monotherapy in early Parkinson's disease. (Parkinson Study Group) Arch Neurol 2003 Dec;60(12):1721-8 PMID: 14676046 SCOPUS ID: 2-s2.0-0346754905 12/17/2003       230 Citations
  • Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families. (Pankratz N, Nichols WC, Uniacke SK, Halter C, Murrell J, Rudolph A, Shults CW, Conneally PM, Foroud T, Parkinson Study Group) Hum Mol Genet 2003 Oct 15;12(20):2599-608 PMID: 12925570 SCOPUS ID: 2-s2.0-10744223494 08/20/2003       133 Citations
  • Significant linkage of Parkinson disease to chromosome 2q36-37. (Pankratz N, Nichols WC, Uniacke SK, Halter C, Rudolph A, Shults C, Conneally PM, Foroud T, Parkinson Study Group) Am J Hum Genet 2003 Apr;72(4):1053-7 PMID: 12638082 PMCID: PMC1180337 SCOPUS ID: 2-s2.0-0345701479 03/15/2003       141 Citations
  • A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. (Parkinson Study Group) Arch Neurol 2002 Dec;59(12):1937-43 PMID: 12470183 SCOPUS ID: 2-s2.0-0036894795 12/21/2002       578 Citations
  • Test-retest reliability of the unified Parkinson's disease rating scale in patients with early Parkinson's disease: results from a multicenter clinical trial. (Siderowf A, McDermott M, Kieburtz K, Blindauer K, Plumb S, Shoulson I, Parkinson Study Group) Mov Disord 2002 Jul;17(4):758-63 PMID: 12210871 SCOPUS ID: 2-s2.0-0036651346 09/05/2002       204 Citations
  • Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families. (Nichols WC, Pankratz N, Uniacke SK, Pauciulo MW, Halter C, Rudolph A, Conneally PM, Foroud T) J Med Genet 2002 Jul;39(7):489-92 PMID: 12114481 PMCID: PMC1735172 SCOPUS ID: 2-s2.0-18444419131 07/13/2002       52 Citations
  • Myoclonus and its disorders. (Blindauer K) Neurol Clin 2001 Aug;19(3):723-34, viii PMID: 11532651 SCOPUS ID: 2-s2.0-0034851101 09/05/2001       14 Citations
  • Incidence of dominant spinocerebellar and Friedreich triplet repeats among 361 ataxia families. (Moseley ML, Benzow KA, Schut LJ, Bird TD, Gomez CM, Barkhaus PE, Blindauer KA, Labuda M, Pandolfo M, Koob MD, Ranum LP) Neurology 1998 Dec;51(6):1666-71 PMID: 9855520 SCOPUS ID: 2-s2.0-0031647246 12/17/1998       206 Citations
  • Single-voxel proton MR spectroscopy of nonneoplastic brain lesions suggestive of a neoplasm. (Krouwer HG, Kim TA, Rand SD, Prost RW, Haughton VM, Ho KC, Jaradeh SS, Meyer GA, Blindauer KA, Cusick JF, Morris GL, Walsh PR) AJNR Am J Neuroradiol 1998 Oct;19(9):1695-703 PMID: 9802493 PMCID: PMC8337475 SCOPUS ID: 2-s2.0-0343526542 11/05/1998       69 Citations
  • Fulminant progression of demyelinating disease after valproate-induced encephalopathy. (Blindauer KA, Harrington G, Morris GL 3rd, Ho KC) Neurology 1998 Jul;51(1):292-5 PMID: 9674826 SCOPUS ID: 2-s2.0-0031868351 07/23/1998       28 Citations
    • Last update: 04/29/2026