Medical College of Wisconsin
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Peter J. Newman PhD

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Cardiovascular Center


Publications (23)

  • Integrin-αIIbβ3-mediated outside-in signalling activates a negative feedback pathway to suppress platelet activation. (Dai B, Wu P, Xue F, Yang R, Yu Z, Dai K, Ruan C, Liu G, Newman PJ, Gao C) Thromb Haemost 2016 Oct 28;116(5):918-930 PMID: 27465472 SCOPUS ID: 2-s2.0-84994571270 10/30/2016       4 Citations
  • The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function. (Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ) J Biol Chem 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 SCOPUS ID: 2-s2.0-85002858868 10/30/2016       13 Citations
  • Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia. (Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ) Arterioscler Thromb Vasc Biol 2016 08;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 SCOPUS ID: 2-s2.0-84973532000 06/11/2016       37 Citations
  • Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). (Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJ) Curr Opin Hematol 2016 May;23(3):253-9 PMID: 27055047 PMCID: PMC4986701 SCOPUS ID: 2-s2.0-84963651443 04/08/2016       86 Citations
  • Structural basis for PECAM-1 homophilic binding. (Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J) Blood 2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 SCOPUS ID: 2-s2.0-84960356253 12/25/2015       25 Citations
  • CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. (Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ) Blood 2016 Feb 11;127(6):675-80 PMID: 26634302 PMCID: PMC4751021 SCOPUS ID: 2-s2.0-84959330331 12/05/2015       24 Citations
  • Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. (Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ) PLoS One 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 SCOPUS ID: 2-s2.0-84942901879 08/21/2015       18 Citations
  • Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. (Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK) PLoS One 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 SCOPUS ID: 2-s2.0-84925859948 03/21/2015       8 Citations
  • Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). (Mei H, Campbell JM, Paddock CM, Lertkiatmongkol P, Mosesson MW, Albrecht R, Newman PJ) J Biol Chem 2014 Jul 25;289(30):20836-44 PMID: 24936065 PMCID: PMC4110291 SCOPUS ID: 2-s2.0-84905407842 06/18/2014       21 Citations
  • PECAM-1: regulator of endothelial junctional integrity. (Privratsky JR, Newman PJ) Cell Tissue Res 2014 Mar;355(3):607-19 PMID: 24435645 PMCID: PMC3975704 SCOPUS ID: 2-s2.0-84899440750 01/18/2014       123 Citations
  • Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. (Kanaji T, Kanaji S, Montgomery RR, Patel SB, Newman PJ) Blood 2013 Oct 10;122(15):2732-42 PMID: 23926302 PMCID: PMC3795464 SCOPUS ID: 2-s2.0-84888251628 08/09/2013       27 Citations
  • Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia. (Bakchoul T, Greinacher A, Sachs UJ, Krautwurst A, Renz H, Harb H, Bein G, Newman PJ, Santoso S) Blood 2013 Jul 18;122(3):321-7 PMID: 23645838 PMCID: PMC3716199 SCOPUS ID: 2-s2.0-84879304669 05/07/2013       25 Citations
  • Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. (Tourdot BE, Brenner MK, Keough KC, Holyst T, Newman PJ, Newman DK) Biochemistry 2013 Apr 16;52(15):2597-608 PMID: 23418871 PMCID: PMC3666314 SCOPUS ID: 2-s2.0-84876268989 02/20/2013       23 Citations
  • Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. (Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ) Blood 2013 Mar 07;121(10):1858-67 PMID: 23264598 PMCID: PMC3591804 SCOPUS ID: 2-s2.0-84876238476 12/25/2012       62 Citations
  • Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. (Kuckleburg CJ, Newman PJ) Arterioscler Thromb Vasc Biol 2013 Feb;33(2):275-84 PMID: 23202369 PMCID: PMC3562705 SCOPUS ID: 2-s2.0-84872954594 12/04/2012       18 Citations
  • Cadherin 6 has a functional role in platelet aggregation and thrombus formation. (Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D) Arterioscler Thromb Vasc Biol 2012 Jul;32(7):1724-31 PMID: 22539596 PMCID: PMC4155514 SCOPUS ID: 2-s2.0-84865282307 04/28/2012       32 Citations
  • Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils. (Kuckleburg CJ, Tilkens SB, Santoso S, Newman PJ) J Immunol 2012 Mar 01;188(5):2419-26 PMID: 22266279 PMCID: PMC3288489 SCOPUS ID: 2-s2.0-84857484531 01/24/2012       46 Citations
  • GPIbα regulates platelet size by controlling the subcellular localization of filamin. (Kanaji T, Ware J, Okamura T, Newman PJ) Blood 2012 Mar 22;119(12):2906-13 PMID: 22174152 PMCID: PMC3327465 SCOPUS ID: 2-s2.0-84858835276 12/17/2011       37 Citations
  • PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. (Privratsky JR, Tilkens SB, Newman DK, Newman PJ) Life Sci 2012 Jan 30;90(5-6):177-84 PMID: 22119535 PMCID: PMC3264774 SCOPUS ID: 2-s2.0-84856097476 11/29/2011       13 Citations
  • Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. (Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ) J Cell Sci 2011 May 01;124(Pt 9):1477-85 PMID: 21486942 PMCID: PMC3078814 SCOPUS ID: 2-s2.0-79955525883 04/14/2011       61 Citations
  • Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. (Paddock C, Lytle BL, Peterson FC, Holyst T, Newman PJ, Volkman BF, Newman DK) Blood 2011 Jun 02;117(22):6012-23 PMID: 21464369 PMCID: PMC3112045 SCOPUS ID: 2-s2.0-79958011812 04/06/2011       27 Citations
  • Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling. (Gao C, Boylan B, Fang J, Wilcox DA, Newman DK, Newman PJ) Blood 2011 May 05;117(18):4946-52 PMID: 21368290 PMCID: PMC3100701 SCOPUS ID: 2-s2.0-79955964309 03/04/2011       80 Citations
  • Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. (Ming Z, Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK) Blood 2011 Apr 07;117(14):3903-6 PMID: 21297004 PMCID: PMC3083302 SCOPUS ID: 2-s2.0-79953835599 02/08/2011       35 Citations
  • Last update: 07/13/2010
    jenkins-FCD Prod-480 9a4deaf152b0b06dd18151814fff2e18f6c05280