Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol 2016 May;23(3):253-9
Date
04/08/2016Pubmed ID
27055047Pubmed Central ID
PMC4986701DOI
10.1097/MOH.0000000000000239Scopus ID
2-s2.0-84963651443 (requires institutional sign-in at Scopus site) 329 CitationsAbstract
PURPOSE OF REVIEW: The purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, platelet/endothelial cell adhesion molecule-1 (PECAM-1), in endothelial cells, with special emphasis on its role in maintaining and restoring the vascular permeability barrier following disruption of the endothelial cell junction.
RECENT FINDINGS: In addition to its role as an inhibitory receptor in circulating platelets and leukocytes, PECAM-1 is highly expressed at endothelial cell-cell junctions, where it functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability barrier following inflammatory or thrombotic challenge.
SUMMARY: Owing to the unique ability of antibodies that bind the membrane proximal region of the extracellular domain to trigger conformational changes leading to affinity modulation and homophilic adhesion strengthening, PECAM-1 might be an attractive target for treating vascular permeability disorders.
Author List
Lertkiatmongkol P, Liao D, Mei H, Hu Y, Newman PJAuthor
Peter J. Newman PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Endothelial CellsHumans
Platelet Endothelial Cell Adhesion Molecule-1
