Medical College of Wisconsin
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Yongxia Wu PhD

Yongxia Wu PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center
Member of the Center for Immunology

View Curriculum Vitae

Research Areas of Interest

  • Antigen-Presenting Cells
  • Graft vs Host Disease
  • T-Lymphocytes
  • Non-Coding RNAs
  • Adoptive Cell Therapy
  • Graft-versus-Leukemia Effect

    • Research Experience

  • Bone Marrow Transplantation
  • Flow Cytometry
  • Metabolic Analysis
  • Cell Proliferation and Differentiation
  • Treg Generation
  • Adoptive T-cell Therapy
  • Mixed Lymphocyte Reaction
  • Cell Isolation and Purification

    • Methodologies and Techniques

  • Blotting, Western
  • Bone Marrow Transplantation
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Polymerase Chain Reaction
  • Transfection
  • Immune Cell Isolation
  • T-cell Activation and Differentiation
  • Solid Tumor Models
  • Metabolic analysis

    • Publications (43)

  • Tipping the GVH/GVL balance by targeting HIF1α. (Wu Y, Yu XZ) Cell Rep Med 2023 Nov 21;4(11):101295 PMID: 37992679 PMCID: PMC10694739 SCOPUS ID: 2-s2.0-85177835310 11/23/2023    
  • Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance. (Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H) Cell Rep 2023 Apr 25;42(4):112314 PMID: 37000627 PMCID: PMC10544673 SCOPUS ID: 2-s2.0-85151481968 04/01/2023       3 Citations
  • The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. (Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, Lefler J, Timmers CD, Yu XZ, Jin VX, Zimmermann MT, Mathison AJ, Urrutia R, Ostrowski MC, Leone G) Nat Commun 2023 Jan 03;14(1):1 PMID: 36596776 PMCID: PMC9810714 SCOPUS ID: 2-s2.0-85145429848 01/04/2023       59 Citations
  • The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract. (Bastian D, Sui X, Choi HJ, Wu Y, Tian L, Yang K, Liu C, Liu Y, Yu XZ) J Immunol 2023 Feb 15;210(4):486-495 PMID: 36548465 PMCID: PMC9938950 SCOPUS ID: 2-s2.0-85147317750 12/23/2022    
  • The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease. (Schutt SD, Wu Y, Kharel A, Bastian D, Choi HJ, Hanief Sofi M, Mealer C, McDaniel Mims B, Nguyen H, Liu C, Helke K, Cui W, Zhang X, Ben-David Y, Yu XZ) J Clin Invest 2022 Nov 01;132(21) PMID: 36074578 PMCID: PMC9621143 SCOPUS ID: 2-s2.0-85141004782 09/09/2022       14 Citations
  • S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission. (Tian L, Wu Y, Choi HJ, Sui X, Li X, Sofi MH, Kassir MF, Chen X, Mehrotra S, Ogretmen B, Yu XZ) Cell Mol Immunol 2022 Nov;19(11):1235-1250 PMID: 36071219 PMCID: PMC9622814 SCOPUS ID: 2-s2.0-85137418710 09/08/2022       22 Citations
  • Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. (Sofi MH, Tian L, Schutt S, Khan I, Choi HJ, Wu Y, Bastian D, Ticer T, Kassir MF, Atilgan FC, Kim J, Sui X, Zivkovic A, Mehrotra S, O'Bryan JP, Stark H, Martin PJ, Ogretmen B, Yu XZ) Leukemia 2022 Jul;36(7):1907-1915 PMID: 35513703 PMCID: PMC9256768 SCOPUS ID: 2-s2.0-85129354225 05/06/2022       11 Citations
  • Variation in blood microbial lipopolysaccharide (LPS) contributes to immune reconstitution in response to suppressive antiretroviral therapy in HIV. (Luo Z, Health SL, Li M, Yang H, Wu Y, Collins M, Deeks SG, Martin JN, Scott A, Jiang W) EBioMedicine 2022 Jun;80:104037 PMID: 35500539 PMCID: PMC9065923 SCOPUS ID: 2-s2.0-85129505975 05/03/2022       23 Citations
  • Editorial: Immunogenomics of Solid Organ and Hematopoietic Stem Cell Transplantation. (Wu Y, Zuber J, Fu J) Front Immunol 2022;13:878314 PMID: 35371062 PMCID: PMC8965839 SCOPUS ID: 2-s2.0-85127477293 04/05/2022    
  • MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice. (Wu Y, Mealer C, Schutt S, Wilson CL, Bastian D, Sofi MH, Zhang M, Luo Z, Choi HJ, Yang K, Tian L, Nguyen H, Helke K, Schnapp LM, Wang H, Yu XZ) Blood Adv 2022 May 24;6(10):3036-3052 PMID: 35073581 PMCID: PMC9131913 SCOPUS ID: 2-s2.0-85130628553 01/25/2022       10 Citations
  • Donor T-Cell Repertoire Profiling in Recipient Lymphoid and Parenchyma Organs Reveals GVHD Pathogenesis at Clonal Levels After Bone Marrow Transplantation in Mice. (Wu Y, Fu J, Wang H, Yu XZ) Front Immunol 2021;12:778996 PMID: 34950143 PMCID: PMC8688739 SCOPUS ID: 2-s2.0-85121630632 12/25/2021       4 Citations
  • Donor T-Cell Repertoire Profiling in Recipient Lymphoid and Parenchyma Organs Reveals GVHD Pathogenesis at Clonal Levels After Bone Marrow Transplantation in Mice (Wu Y, Fu J, Wang H, Yu XZ) Frontiers in Immunology 7 December 2021;12 SCOPUS ID: 2-s2.0-85121630632 12/07/2021       4 Citations
  • Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain. (Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf BJ, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett ED, Jiang W) EBioMedicine 2021 Dec;74:103701 PMID: 34826801 PMCID: PMC8626580 SCOPUS ID: 2-s2.0-85119619479 11/27/2021       10 Citations
  • XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1α-Dependent Decay. (Choi HJ, Tang CA, Tian L, Wu Y, Sofi MH, Ticer T, Schutt SD, Hu CA, Yu XZ) Front Immunol 2021;12:705484 PMID: 34659198 PMCID: PMC8517405 SCOPUS ID: 2-s2.0-85117251520 10/19/2021       4 Citations
  • Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. (Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H) J Clin Invest 2021 Aug 16;131(16) PMID: 34255748 PMCID: PMC8363288 SCOPUS ID: 2-s2.0-85113146308 07/14/2021       31 Citations
  • Interleukin-23 receptor signaling by interleukin-39 potentiates T cell pathogenicity in acute graft-versus-host disease. (Bastian D, Sui X, Nguyen HD, Wu Y, Schutt S, Tian L, Sofi MH, Liu Y, Martin P, Bartee E, Yu XZ) Am J Transplant 2021 Nov;21(11):3538-3549 PMID: 33934505 SCOPUS ID: 2-s2.0-85107315823 05/03/2021       12 Citations
  • A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD. (Sofi MH, Wu Y, Ticer T, Schutt S, Bastian D, Choi HJ, Tian L, Mealer C, Liu C, Westwater C, Armeson KE, Alekseyenko AV, Yu XZ) JCI Insight 2021 Feb 08;6(3) PMID: 33554953 PMCID: PMC7934839 SCOPUS ID: 2-s2.0-85101018758 02/09/2021       63 Citations
  • STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function. (Wu Y, Tang CA, Mealer C, Bastian D, Hanief Sofi M, Tian L, Schutt S, Choi HJ, Ticer T, Zhang M, Sui X, Huang L, Mellor AL, Hu CA, Yu XZ) Cell Mol Immunol 2021 Mar;18(3):632-643 PMID: 33500563 PMCID: PMC8027033 SCOPUS ID: 2-s2.0-85099750259 01/28/2021       7 Citations
  • Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease. (Nguyen H, Alawieh A, Bastian D, Kuril S, Dai M, Daenthanasanmak A, Zhang M, Iamsawat S, Schutt SD, Wu Y, Sleiman MM, Shetty A, Atkinson C, Sun S, Varela JC, Tomlinson S, Yu XZ) Clin Cancer Res 2020 Jul 01;26(13):3481-3490 PMID: 31919135 PMCID: PMC7334060 SCOPUS ID: 2-s2.0-85087469837 01/11/2020       9 Citations
  • Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse. (Iamsawat S, Tian L, Daenthanasanmak A, Wu Y, Nguyen HD, Bastian D, Yu XZ) Blood Adv 2019 Dec 23;3(24):4187-4201 PMID: 31856270 PMCID: PMC6929397 SCOPUS ID: 2-s2.0-85077917688 12/20/2019       20 Citations
  • The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease. (Bastian D, Wu Y, Betts BC, Yu XZ) Front Immunol 2019;10:988 PMID: 31139181 PMCID: PMC6518430 SCOPUS ID: 2-s2.0-85067295445 05/30/2019       61 Citations
  • Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. (Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ) J Clin Invest 2019 May 02;129(7):2760-2774 PMID: 31045571 PMCID: PMC6597211 SCOPUS ID: 2-s2.0-85068520003 05/03/2019       32 Citations
  • Systemic translocation of Staphylococcus drives autoantibody production in HIV disease. (Luo Z, Li M, Wu Y, Meng Z, Martin L, Zhang L, Ogunrinde E, Zhou Z, Qin S, Wan Z, Westerink MAJ, Warth S, Liu H, Jin P, Stroncek D, Li QZ, Wang E, Wu X, Heath SL, Li Z, Alekseyenko AV, Jiang W) Microbiome 2019 Feb 14;7(1):25 PMID: 30764863 PMCID: PMC6376754 SCOPUS ID: 2-s2.0-85061603507 02/16/2019       22 Citations
  • Modelling CAR-T therapy in humanized mice. (Wu Y, Yu XZ) EBioMedicine 2019 Feb;40:25-26 PMID: 30665855 PMCID: PMC6413350 SCOPUS ID: 2-s2.0-85060100966 01/23/2019       11 Citations
  • Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. (Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu XZ) JCI Insight 2018 Dec 20;3(24) PMID: 30568037 PMCID: PMC6338312 SCOPUS ID: 2-s2.0-85063246991 12/21/2018       29 Citations
  • Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells. (Zhang M, Wu Y, Bastian D, Iamsawat S, Chang J, Daenthanasanmak A, Nguyen HD, Schutt S, Dai M, Chen F, Suh WK, Yu XZ) Front Immunol 2018;9:1461 PMID: 29988391 PMCID: PMC6023972 SCOPUS ID: 2-s2.0-85048926363 07/11/2018       19 Citations
  • PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. (Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen HD, Bastian D, Zhang M, Sofi MH, Chatterjee S, Hill EG, Mehrotra S, Kraft AS, Yu XZ) J Clin Invest 2018 Jul 02;128(7):2787-2801 PMID: 29781812 PMCID: PMC6025986 SCOPUS ID: 2-s2.0-85049843113 05/22/2018       30 Citations
  • MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. (Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, Sofi MH, Nguyen H, Dai M, Liu C, Chang YJ, Blazar BR, Yu XZ) Blood 2018 Apr 26;131(17):1974-1986 PMID: 29530952 PMCID: PMC5921962 SCOPUS ID: 2-s2.0-85047856364 03/14/2018       50 Citations
  • Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. (Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ) Blood Adv 2018 Feb 27;2(4):414-427 PMID: 29483082 PMCID: PMC5858472 SCOPUS ID: 2-s2.0-85060136813 02/28/2018       21 Citations
  • Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. (Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y, Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K, Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C, Pidala J, Anasetti C, Yu XZ) Proc Natl Acad Sci U S A 2018 Feb 13;115(7):1582-1587 PMID: 29382747 PMCID: PMC5816153 SCOPUS ID: 2-s2.0-85042003500 02/01/2018       63 Citations
  • IL-27 Receptor Signaling on T cells Augments GVHD Severity through Enhancing Th1 Responses. (Bastian D, Liu Y, Wu Y, Schutt S, Nguyen HD, Daenthanasanmak A, Sofi MH, Zhang M, Iamsuwat S, Yu XZ) J Immunol Res Ther 2018;3(1):151-157 PMID: 30906912 PMCID: PMC6426137 01/01/2018    
  • T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. (Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM) Blood 2017 Jul 13;130(2):146-155 PMID: 28550044 PMCID: PMC5510785 SCOPUS ID: 2-s2.0-85023757456 05/28/2017       60 Citations
  • Ceramide synthesis regulates T cell activity and GVHD development. (Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ) JCI Insight 2017 May 18;2(10) PMID: 28515365 PMCID: PMC5436544 SCOPUS ID: 2-s2.0-85099809147 05/19/2017       35 Citations
  • IL-17A ≠ Th17 in GvHD. (Wu Y, Yu XZ) Cell Mol Immunol 2018 Mar;15(3):282-283 PMID: 27796285 PMCID: PMC5843611 SCOPUS ID: 2-s2.0-85042920910 11/01/2016       6 Citations
  • CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice. (Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ) Oncoimmunology 2016 Jun;5(6):e1146842 PMID: 27471614 PMCID: PMC4938369 SCOPUS ID: 2-s2.0-84969706587 07/30/2016       51 Citations
  • Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation. (Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D, Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu C, Wang H, Chi H, Mehrotra S, Yu XZ) J Clin Invest 2016 Apr 01;126(4):1337-52 PMID: 26950421 PMCID: PMC4811142 SCOPUS ID: 2-s2.0-84964600705 03/08/2016       93 Citations
  • T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. (Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ) J Immunol 2016 Apr 01;196(7):3168-79 PMID: 26903480 PMCID: PMC4799777 SCOPUS ID: 2-s2.0-84962523010 02/24/2016       6 Citations
  • Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice. (Schutt SD, Fu J, Nguyen H, Bastian D, Heinrichs J, Wu Y, Liu C, McDonald DG, Pidala J, Yu XZ) PLoS One 2015;10(9):e0137641 PMID: 26348529 PMCID: PMC4562702 SCOPUS ID: 2-s2.0-84945231899 09/09/2015       78 Citations
  • MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. (Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen H, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ) Blood 2015 Sep 10;126(11):1314-23 PMID: 26138686 PMCID: PMC4566810 SCOPUS ID: 2-s2.0-84942512521 07/04/2015       58 Citations
  • Essential Role of Interleukin-12/23p40 in the Development of Graft-versus-Host Disease in Mice. (Wu Y, Bastian D, Schutt S, Nguyen H, Fu J, Heinrichs J, Xia C, Yu XZ) Biol Blood Marrow Transplant 2015 Jul;21(7):1195-204 PMID: 25846718 PMCID: PMC4466028 SCOPUS ID: 2-s2.0-84930576723 04/08/2015       24 Citations
  • T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function. (Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald DG, Anasetti C, Yu XZ) J Immunol 2015 Jan 01;194(1):388-97 PMID: 25404360 PMCID: PMC4314960 SCOPUS ID: 2-s2.0-84919663260 11/19/2014       34 Citations
  • Tolerance induction between two different strains of parental mice prevents graft-versus-host disease in haploidentical hematopoietic stem cell transplantation to F1 mice. (Guo Y, Zhang L, Wan S, Sun X, Wu Y, Yu XZ, Xia CQ) Biochem Biophys Res Commun 2014 Apr 18;446(4):1035-41 PMID: 24661874 SCOPUS ID: 2-s2.0-84899490787 03/26/2014       2 Citations
  • Effects of rosuvastatin and atorvastatin on renal function: meta-analysis. (Wu Y, Wang Y, An C, Dong Z, Liu H, Zhang Y, Zhang M, An F) Circ J 2012;76(5):1259-66 PMID: 22382383 SCOPUS ID: 2-s2.0-84860126383 03/03/2012       30 Citations
    • Last update: 06/30/2025