Faculty Collaboration Database

Effects of rosuvastatin and atorvastatin on renal function: meta-analysis. Circ J 2012;76(5):1259-66

Date

03/03/2012

Pubmed ID

22382383

DOI

10.1253/circj.cj-11-1385

Scopus ID

2-s2.0-84860126383 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

BACKGROUND: Several clinical trials have reported inconsistent findings for the effects of rosuvastatin (RSV) and atorvastatin (ATV) on renal function. The aim of this meta-analysis was to investigate the effects of these 2 statins on glomerular filtration rate (GFR) and proteinuria respectively, and determine which is better.

METHODS AND RESULTS: PubMed, CENTRAL, Web of Knowledge, and ClinicalTrials.gov website were searched for randomized controlled trials. Eligible studies reported GFR and/or proteinuria during treatment with RSV or ATV compared with control (placebo, no statins, or usual care), or RSV compared with ATV head to head. Trials that enrolled dialysis participants and teenagers were excluded. Statistical heterogeneity was assessed using the I(2) statistic, and pooled results using the random-effects model. The standardized mean differences (SMD) and ratio of means (ROM) were measured, respectively, to analyze GFR and proteinuria. Sixteen trials with a total number of 24,278 participants were identified. Compared with control, changes in the SMD of GFR were 0.04 (95% confidence interval [CI]: 0.01-0.07) and 0.59 (95%CI: 0.12-1.06) for RSV and ATV, respectively. The ROMs of proteinuria were 0.59 (95%CI: 0.46-0.74) for RSV vs. the control group, and 1.23 (95%CI: 1.05-1.43) in the head-to-head comparison.

CONCLUSIONS: Both RSV and ATV improve GFR, and ATV seems to be more effective in reducing proteinuria. The validity and clinical significance require high-quality intensive studies with composite clinic endpoints of kidney and death.

Author List

Wu Y, Wang Y, An C, Dong Z, Liu H, Zhang Y, Zhang M, An F

Author

Yongxia Wu PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Female
Fluorobenzenes
Glomerular Filtration Rate
Heptanoic Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Kidney
Male
Proteinuria
PubMed
Pyrimidines
Pyrroles
Randomized Controlled Trials as Topic
Rosuvastatin Calcium
Sulfonamides