Possible noradrenergic involvement in naloxone potentiation of apomorphine-induced stereotypic climbing in mice. Pharmacol Biochem Behav 1984 Nov;21(5):733-6
Date
11/01/1984Pubmed ID
6096896DOI
10.1016/s0091-3057(84)80011-8Scopus ID
2-s2.0-0021689775 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Apomorphine-induced stereotypic climbing behavior in mice was significantly potentiated by pretreatment with the opiate receptor blocker naloxone. In animals additionally pretreated with alpha-methyl-p-tyrosine, brain levels of norepinephrine (NE) and dopamine (DA) were markedly reduced and naloxone potentiation of apomorphine-induced stereotypic climbing was blocked. In mice pretreated with diethyldithiocarbamic acid, brain NE was slightly reduced, brain DA was slightly elevated but naloxone potentiation of apomorphine-induced stereotypic climbing was unaltered. In animals pretreated with reserpine, both brain NE and DA were significantly reduced by naloxone potentiation of apomorphine-induced stereotypic climbing was not affected. In other experiments, pretreatment with low doses of the alpha-adrenergic receptor blocker BE-2254 failed to suppress climbing activity induced by apomorphine alone but did successfully prevent naloxone potentiation of apomorphine-induced stereotypic climbing. These findings suggest the possibility that NE and alpha-adrenergic receptors might play a role in the potentiating influence of naloxone upon apomorphine-induced stereotypic climbing activity in mice.
Author List
Quock RM, Bloom AS, Sadowski JAAuthor
Alan Bloom PhD, MA Emeritus Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApomorphine
Brain
Ditiocarb
Dopamine
Drug Synergism
Humans
Male
Methyltyrosines
Mice
Mice, Inbred ICR
Naloxone
Norepinephrine
Reserpine
Stereotyped Behavior
alpha-Methyltyrosine
