Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges. J Clin Microbiol 2019 Jul;57(7)
Date
05/03/2019Pubmed ID
31043466Pubmed Central ID
PMC6595443DOI
10.1128/JCM.00425-19Scopus ID
2-s2.0-85068514285 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
Sepsis is a major source of mortality and morbidity globally. Accurately diagnosing sepsis remains challenging due to the heterogeneous nature of the disease, and delays in diagnosis and intervention contribute to high mortality rates. Measuring the host response to infection enables more rapid diagnosis of sepsis than is possible through direct detection of the causative pathogen, and recent advances in host response diagnostics and prognostics hold promise for improving outcomes. The current review discusses recent advances in the technologies used to probe the host response to infection, particularly those based on transcriptomics. These are discussed in the context of contemporary approaches to diagnosing and prognosing sepsis, and recommendations are made for successful development and validation of host response technologies.
Author List
Gunsolus IL, Sweeney TE, Liesenfeld O, Ledeboer NAAuthor
Nathan A. Ledeboer PhD Chief, Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersGene Expression Profiling
Humans
Inflammation
Leukocytes
Molecular Diagnostic Techniques
Prognosis
Sepsis
