Medical College of Wisconsin
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Insulin biosynthesis: the IREny of it all. Cell Metab 2006 Sep;4(3):175-6

Date

09/05/2006

Pubmed ID

16950132

DOI

10.1016/j.cmet.2006.08.007

Scopus ID

2-s2.0-33747839083 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of insulin-producing beta cells. Work in this issue of Cell Metabolism (Lipson et al., 2006) identifies a novel role for UPR activation in beta cell function by demonstrating that the UPR effector IRE1 is a positive regulator of glucose-stimulated proinsulin biosynthesis.

Author List

Corbett JA

Author

John A. Corbett PhD Chair, Professor in the Biochemistry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
DNA-Binding Proteins
Endoribonucleases
Enzyme Activation
Glucose
Heat-Shock Proteins
Humans
Insulin
Insulin-Secreting Cells
Membrane Proteins
Molecular Chaperones
Nuclear Proteins
Phosphorylation
Proinsulin
Protein Folding
Regulatory Factor X Transcription Factors
Transcription Factors