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John A. Corbett PhD

Chair, Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Center for Immunology
Member of the Neuroscience Research Center

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Publications (180)

β-cell-selective inhibition of DNA damage response signaling by nitric oxide is associated with an attenuation in glucose uptake. (Yeo CT, Kropp EM, Hansen PA, Pereckas M, Oleson BJ, Naatz A, Stancill JS, Ross KA, Gundry RL, Corbett JA) J Biol Chem 2023 Mar;299(3):102994 PMID: 36773802 PMCID: PMC10023961 SCOPUS ID: 2-s2.0-85150358100 02/12/2023

Hydrogen peroxide detoxification through the peroxiredoxin/thioredoxin antioxidant system: A look at the pancreatic β-cell oxidant defense. (Stancill JS, Corbett JA) Vitam Horm 2023;121:45-66 PMID: 36707143 PMCID: PMC10058777 SCOPUS ID: 2-s2.0-85146001426 01/28/2023 1 Citation

Hydrogen peroxide detoxification through the peroxiredoxin/thioredoxin antioxidant system: A look at the pancreatic β-cell oxidant defense (Stancill JS, Corbett JA) Vitamins and Hormones January 2023;121:45-66 SCOPUS ID: 2-s2.0-85146001426 01/01/2023 1 Citation

Editorial: Understanding the gene expression of β cell dysfunction in diabetes. (Sjöholm Å, Corbett JA, Leung PS, Portha B) Front Endocrinol (Lausanne) 2022;13:1069991 PMID: 36440197 PMCID: PMC9692067 SCOPUS ID: 2-s2.0-85142644101 11/29/2022 1 Citation

T cell-extrinsic IL-1 signaling controls long-term gammaherpesvirus infection by suppressing viral reactivation. (Sylvester PA, Corbett JA, Tarakanova VL) Virology 2022 Nov;576:134-140 PMID: 36244319 PMCID: PMC10069094 SCOPUS ID: 2-s2.0-85139738671 10/17/2022 1 Citation

N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. (Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC) Front Endocrinol (Lausanne) 2022;13:923925 PMID: 36176467 PMCID: PMC9513428 SCOPUS ID: 2-s2.0-85138892468 10/01/2022 4 Citations

Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs β-Cell Function. (Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA) Function (Oxf) 2022;3(4):zqac034 PMID: 35873655 PMCID: PMC9301323 SCOPUS ID: 2-s2.0-85138214139 07/26/2022 10 Citations

Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells. (Stancill JS, Kasmani MY, Khatun A, Cui W, Corbett JA) Function (Oxf) 2022;3(1):zqab063 PMID: 34927076 PMCID: PMC8674205 SCOPUS ID: 2-s2.0-85130232097 12/21/2021 6 Citations

The Role of Thioredoxin/Peroxiredoxin in the β-Cell Defense Against Oxidative Damage. (Stancill JS, Corbett JA) Front Endocrinol (Lausanne) 2021;12:718235 PMID: 34557160 PMCID: PMC8453158 SCOPUS ID: 2-s2.0-85115392938 09/25/2021 28 Citations

Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection. (Volberding PJ, Xin G, Kasmani MY, Khatun A, Brown AK, Nguyen C, Stancill JS, Martinez E, Corbett JA, Cui W) Cell Rep 2021 May 25;35(8):109160 PMID: 34038722 PMCID: PMC8182757 SCOPUS ID: 2-s2.0-85106489485 05/27/2021 10 Citations

Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines. (Stancill JS, Kasmani MY, Khatun A, Cui W, Corbett JA) Life Sci Alliance 2021 Jun;4(6) PMID: 33883217 PMCID: PMC8091599 SCOPUS ID: 2-s2.0-85105569108 04/23/2021 16 Citations

Regulation of ATR-dependent DNA damage response by nitric oxide. (Yeo CT, Stancill JS, Oleson BJ, Schnuck JK, Stafford JD, Naatz A, Hansen PA, Corbett JA) J Biol Chem 2021;296:100388 PMID: 33567339 PMCID: PMC7967039 SCOPUS ID: 2-s2.0-85102940015 02/11/2021 4 Citations

Mitophagy protects β cells from inflammatory damage in diabetes. (Sidarala V, Pearson GL, Parekh VS, Thompson B, Christen L, Gingerich MA, Zhu J, Stromer T, Ren J, Reck EC, Chai B, Corbett JA, Mandrup-Poulsen T, Satin LS, Soleimanpour SA) JCI Insight 2020 Dec 17;5(24) PMID: 33232298 PMCID: PMC7819751 SCOPUS ID: 2-s2.0-85097820706 11/25/2020 59 Citations

Inhibition of oxidative metabolism by nitric oxide restricts EMCV replication selectively in pancreatic beta-cells. (Stafford JD, Yeo CT, Corbett JA) J Biol Chem 2020 Dec 25;295(52):18189-18198 PMID: 33100269 PMCID: PMC7939444 SCOPUS ID: 2-s2.0-85098251411 10/27/2020 7 Citations

Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis. (Stafford JD, Shaheen ZR, Yeo CT, Corbett JA) J Biol Chem 2020 Dec 04;295(49):16655-16664 PMID: 32972972 PMCID: PMC7864063 SCOPUS ID: 2-s2.0-85097570380 09/26/2020 5 Citations

Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite. (Stancill JS, Happ JT, Broniowska KA, Hogg N, Corbett JA) Am J Physiol Regul Integr Comp Physiol 2020 May 01;318(5):R1004-R1013 PMID: 32292063 PMCID: PMC7272767 SCOPUS ID: 2-s2.0-85084379321 04/16/2020 35 Citations

Can insulin secreting pancreatic β-cells provide novel insights into the metabolic regulation of the DNA damage response? (Oleson BJ, Corbett JA) Biochem Pharmacol 2020 Jun;176:113907 PMID: 32171728 PMCID: PMC7263971 SCOPUS ID: 2-s2.0-85082676643 03/17/2020 7 Citations

SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates. (Waas M, Snarrenberg ST, Littrell J, Jones Lipinski RA, Hansen PA, Corbett JA, Gundry RL) Bioinformatics 2020 Jun 01;36(11):3447-3456 PMID: 32053146 PMCID: PMC7267825 SCOPUS ID: 2-s2.0-85085770971 02/14/2020 31 Citations

The location of sensing determines the pancreatic β-cell response to the viral mimetic dsRNA. (Shaheen ZR, Stafford JD, Voss MG, Oleson BJ, Stancill JS, Corbett JA) J Biol Chem 2020 Feb 21;295(8):2385-2397 PMID: 31915247 PMCID: PMC7039570 SCOPUS ID: 2-s2.0-85079888996 01/10/2020 4 Citations

The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide. (Oleson BJ, Broniowska KA, Yeo CT, Flancher M, Naatz A, Hogg N, Tarakanova VL, Corbett JA) Mol Cell Biol 2019 Sep 15;39(18) PMID: 31235477 PMCID: PMC6712938 SCOPUS ID: 2-s2.0-85071713105 06/27/2019 12 Citations

Sleeve gastrectomy in obese Wistar rats improves diastolic function and promotes cardiac recovery independent of weight loss. (Hayes H, Patz J, Corbett J, Afzal MZ, Strande J, Kindel TL) Surg Obes Relat Dis 2019 Jun;15(6):837-842 PMID: 31101567 PMCID: PMC6682432 SCOPUS ID: 2-s2.0-85065518973 05/19/2019 8 Citations

CCR5 is a required signaling receptor for macrophage expression of inflammatory genes in response to viral double-stranded RNA. (Shaheen ZR, Christmann BS, Stafford JD, Moran JM, Buller RML, Corbett JA) Am J Physiol Regul Integr Comp Physiol 2019 May 01;316(5):R525-R534 PMID: 30811246 PMCID: PMC6589596 SCOPUS ID: 2-s2.0-85065293566 02/28/2019 15 Citations

Pancreatic β-cells detoxify H₂O₂ through the peroxiredoxin/thioredoxin antioxidant system. (Stancill JS, Broniowska KA, Oleson BJ, Naatz A, Corbett JA) J Biol Chem 2019 Mar 29;294(13):4843-4853 PMID: 30659092 PMCID: PMC6442057 SCOPUS ID: 2-s2.0-85063968215 01/20/2019 58 Citations

Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide-Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells. (Oleson BJ, Naatz A, Proudfoot SC, Yeo CT, Corbett JA) Diabetes 2018 May;67(5):898-910 PMID: 29444892 PMCID: PMC5909998 SCOPUS ID: 2-s2.0-85046011042 02/16/2018 7 Citations

Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. (Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM, Corbett JA) Mol Cell Biol 2018 Apr 15;38(8) PMID: 29378831 PMCID: PMC5879465 SCOPUS ID: 2-s2.0-85044766344 01/31/2018 3 Citations

Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons. (Schwab AJ, Sison SL, Meade MR, Broniowska KA, Corbett JA, Ebert AD) Stem Cell Reports 2017 Dec 12;9(6):1839-1852 PMID: 29129681 PMCID: PMC5785678 SCOPUS ID: 2-s2.0-85033362137 11/14/2017 67 Citations

Dual Role of Nitric Oxide in Regulating the Response of β Cells to DNA Damage. (Oleson BJ, Corbett JA) Antioxid Redox Signal 2018 Nov 10;29(14):1432-1445 PMID: 28978225 PMCID: PMC6166691 SCOPUS ID: 2-s2.0-85054363061 10/06/2017 26 Citations

Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats. (Kindel TL, Foster T, Goldspink P, Kindel SJ, Corbett J, Widlanksy M, Strande J) Obes Surg 2017 Sep;27(9):2370-2377 PMID: 28299572 PMCID: PMC5937684 SCOPUS ID: 2-s2.0-85015163077 03/17/2017 14 Citations

Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores. (Kropp EM, Broniowska KA, Waas M, Nycz A, Corbett JA, Gundry RL) Stem Cells Transl Med 2017 Apr;6(4):1191-1201 PMID: 28224719 PMCID: PMC5442850 SCOPUS ID: 2-s2.0-85017570513 02/23/2017 2 Citations

A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat. (Hye Khan MA, Hwang SH, Sharma A, Corbett JA, Hammock BD, Imig JD) Prostaglandins Other Lipid Mediat 2016 Sep;125:40-7 PMID: 27432695 PMCID: PMC5035206 SCOPUS ID: 2-s2.0-84979211632 07/20/2016 37 Citations

Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. (Oleson BJ, Broniowska KA, Naatz A, Hogg N, Tarakanova VL, Corbett JA) Mol Cell Biol 2016 Aug 01;36(15):2067-77 PMID: 27185882 PMCID: PMC4946431 SCOPUS ID: 2-s2.0-85000890117 05/18/2016 32 Citations

Hypoglycemia unawareness prevention: Targeting glucagon production. (Samson WK, Stein LM, Elrick M, Salvatori A, Kolar G, Corbett JA, Yosten GL) Physiol Behav 2016 Aug 01;162:147-50 PMID: 27080082 PMCID: PMC4899234 SCOPUS ID: 2-s2.0-84963657753 04/16/2016 7 Citations

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells. (Elrick MM, Samson WK, Corbett JA, Salvatori AS, Stein LM, Kolar GR, Naatz A, Yosten GL) Am J Physiol Regul Integr Comp Physiol 2016 Jan 15;310(2):R143-55 PMID: 26561648 PMCID: PMC4796643 SCOPUS ID: 2-s2.0-84983172665 11/13/2015 34 Citations

CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection. (Shaheen ZR, Naatz A, Corbett JA) J Immunol 2015 Nov 01;195(9):4406-14 PMID: 26408666 PMCID: PMC4610876 SCOPUS ID: 2-s2.0-84945162363 09/27/2015 11 Citations

Macrophage Expression of Inflammatory Genes in Response to EMCV Infection. (Shaheen ZR, Corbett JA) Biomolecules 2015 Aug 18;5(3):1938-54 PMID: 26295266 PMCID: PMC4598781 SCOPUS ID: 2-s2.0-85012042916 08/22/2015 5 Citations

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines. (Oleson BJ, McGraw JA, Broniowska KA, Annamalai M, Chen J, Bushkofsky JR, Davis DB, Corbett JA, Mathews CE) Am J Physiol Regul Integr Comp Physiol 2015 Sep;309(5):R525-34 PMID: 26084699 PMCID: PMC4591379 SCOPUS ID: 2-s2.0-84940639041 06/19/2015 35 Citations

Reply to Gurgul-Convey and Lenzen: Cytokines, nitric oxide, and β-cells. (Broniowska KA, Mathews CE, Corbett JA) J Biol Chem 2015 Apr 17;290(16):10571 PMID: 26065037 PMCID: PMC4400365 SCOPUS ID: 2-s2.0-84928041403 06/13/2015 1 Citation

Understanding peptide biology: The discovery and characterization of the novel hormone, neuronostatin. (Yosten GL, Elrick MM, Salvatori A, Stein LM, Kolar GR, Ren J, Corbett JA, Samson WK) Peptides 2015 Oct;72:192-5 PMID: 26051024 PMCID: PMC4641813 SCOPUS ID: 2-s2.0-84946488912 06/09/2015 12 Citations

ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection. (Kulinski JM, Darrah EJ, Broniowska KA, Mboko WP, Mounce BC, Malherbe LP, Corbett JA, Gauld SB, Tarakanova VL) Virology 2015 Sep;483:264-74 PMID: 26001649 PMCID: PMC4516584 SCOPUS ID: 2-s2.0-84929458199 05/24/2015 10 Citations

Inhibition of an NAD⁺ salvage pathway provides efficient and selective toxicity to human pluripotent stem cells. (Kropp EM, Oleson BJ, Broniowska KA, Bhattacharya S, Chadwick AC, Diers AR, Hu Q, Sahoo D, Hogg N, Boheler KR, Corbett JA, Gundry RL) Stem Cells Transl Med 2015 May;4(5):483-93 PMID: 25834119 PMCID: PMC4414215 SCOPUS ID: 2-s2.0-84930445700 04/03/2015 20 Citations

How the location of superoxide generation influences the β-cell response to nitric oxide. (Broniowska KA, Oleson BJ, McGraw J, Naatz A, Mathews CE, Corbett JA) J Biol Chem 2015 Mar 20;290(12):7952-60 PMID: 25648890 PMCID: PMC4367293 SCOPUS ID: 2-s2.0-84925310785 02/05/2015 19 Citations

PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. (Meares GP, Liu Y, Rajbhandari R, Qin H, Nozell SE, Mobley JA, Corbett JA, Benveniste EN) Mol Cell Biol 2014 Oct;34(20):3911-25 PMID: 25113558 PMCID: PMC4187715 SCOPUS ID: 2-s2.0-84907157987 08/13/2014 169 Citations

Enhanced MIN-6 beta cell survival and function on a nitric oxide-releasing peptide amphiphile nanomatrix. (Lim DJ, Andukuri A, Vines JB, Rahman SM, Hwang PT, Kim J, Shalev A, Corbett JA, Jun HW) Int J Nanomedicine 2014;9 Suppl 1(Suppl 1):13-21 PMID: 24872700 PMCID: PMC4024973 SCOPUS ID: 2-s2.0-84900462003 05/30/2014 6 Citations

Amyloid and the macrophage: it's all about local production of IL-1β. (Broniowska KA, Corbett JA) Diabetes 2014 May;63(5):1448-50 PMID: 24757195 PMCID: PMC3994949 SCOPUS ID: 2-s2.0-84899111253 04/24/2014 2 Citations

Luminol-based chemiluminescent signals: clinical and non-clinical application and future uses. (Khan P, Idrees D, Moxley MA, Corbett JA, Ahmad F, von Figura G, Sly WS, Waheed A, Hassan MI) Appl Biochem Biotechnol 2014 May;173(2):333-55 PMID: 24752935 PMCID: PMC4426882 SCOPUS ID: 2-s2.0-84899815617 04/23/2014 207 Citations

Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic α-cell. (Salvatori AS, Elrick MM, Samson WK, Corbett JA, Yosten GL) Am J Physiol Endocrinol Metab 2014 Jun 01;306(11):E1257-63 PMID: 24735892 PMCID: PMC4042099 SCOPUS ID: 2-s2.0-84901710347 04/17/2014 22 Citations

Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. (Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA) J Biol Chem 2014 Apr 18;289(16):11454-11464 PMID: 24610783 PMCID: PMC4036281 SCOPUS ID: 2-s2.0-84898944668 03/13/2014 25 Citations

β-Cell responses to nitric oxide. (Broniowska KA, Oleson BJ, Corbett JA) Vitam Horm 2014;95:299-322 PMID: 24559923 SCOPUS ID: 2-s2.0-84894093437 02/25/2014 38 Citations

Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs. (Afolayan AJ, Teng RJ, Eis A, Rana U, Broniowska KA, Corbett JA, Pritchard K, Konduri GG) Am J Physiol Lung Cell Mol Physiol 2014 Feb 15;306(4):L351-60 PMID: 24375796 PMCID: PMC3920226 SCOPUS ID: 2-s2.0-84894025712 01/01/2014 43 Citations

Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. (King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC) PLoS One 2013;8(10):e77452 PMID: 24204831 PMCID: PMC3799630 SCOPUS ID: 2-s2.0-84885725858 11/10/2013 10 Citations

Do β-cells generate peroxynitrite in response to cytokine treatment? (Broniowska KA, Mathews CE, Corbett JA) J Biol Chem 2013 Dec 20;288(51):36567-78 PMID: 24194521 PMCID: PMC3868769 SCOPUS ID: 2-s2.0-84890957625 11/07/2013 23 Citations

Improved MIN6 β-cell function on self-assembled peptide amphiphile nanomatrix inscribed with extracellular matrix-derived cell adhesive ligands. (Lim DJ, Antipenko SV, Vines JB, Andukuri A, Hwang PT, Hadley NT, Rahman SM, Corbett JA, Jun HW) Macromol Biosci 2013 Oct;13(10):1404-12 PMID: 23966265 SCOPUS ID: 2-s2.0-84885948382 08/24/2013 12 Citations

Immunoproteasome Activation During Early Antiviral Response in Mouse Pancreatic β-cells: New Insights into Auto-antigen Generation in Type I Diabetes? (Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA, Skowyra D) J Clin Cell Immunol 2013 Apr 23;4(2) PMID: 23956946 PMCID: PMC3744835 08/21/2013

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. (Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ) Immunity 2013 Jul 25;39(1):111-22 PMID: 23871208 PMCID: PMC3830738 SCOPUS ID: 2-s2.0-84880733694 07/23/2013 155 Citations

Effect of nitric oxide on naphthoquinone toxicity in endothelial cells: role of bioenergetic dysfunction and poly (ADP-ribose) polymerase activation. (Broniowska KA, Diers AR, Corbett JA, Hogg N) Biochemistry 2013 Jun 25;52(25):4364-72 PMID: 23718265 PMCID: PMC4028014 SCOPUS ID: 2-s2.0-84879545058 05/31/2013 21 Citations

Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway. (Bai X, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Zaja I, Corbett JA, Bosnjak ZJ) Anesth Analg 2013 Apr;116(4):869-80 PMID: 23460563 PMCID: PMC3606677 SCOPUS ID: 2-s2.0-84876694073 03/06/2013 159 Citations

Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNβ in mouse pancreatic β-cells. (Freudenburg W, Gautam M, Chakraborty P, James J, Richards J, Salvatori AS, Baldwin A, Schriewer J, Buller RM, Corbett JA, Skowyra D) PLoS One 2013;8(2):e52408 PMID: 23383295 PMCID: PMC3562186 SCOPUS ID: 2-s2.0-84873271342 02/06/2013 22 Citations

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. (Padgett LE, Broniowska KA, Hansen PA, Corbett JA, Tse HM) Ann N Y Acad Sci 2013 Apr;1281(1):16-35 PMID: 23323860 PMCID: PMC3715103 SCOPUS ID: 2-s2.0-84875674753 01/18/2013 226 Citations

Differential responses of pancreatic β-cells to ROS and RNS. (Meares GP, Fontanilla D, Broniowska KA, Andreone T, Lancaster JR Jr, Corbett JA) Am J Physiol Endocrinol Metab 2013 Mar 15;304(6):E614-22 PMID: 23321474 PMCID: PMC3602694 SCOPUS ID: 2-s2.0-84877276240 01/17/2013 33 Citations

Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway. (Bosnjak ZJ, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Wells CW, Corbett JA, Bai X) Curr Drug Saf 2012 Apr;7(2):106-19 PMID: 22873495 PMCID: PMC3684944 SCOPUS ID: 2-s2.0-84864798841 08/10/2012 70 Citations

Cytokine-mediated β-cell damage in PARP-1-deficient islets. (Andreone T, Meares GP, Hughes KJ, Hansen PA, Corbett JA) Am J Physiol Endocrinol Metab 2012 Jul 15;303(2):E172-9 PMID: 22535743 PMCID: PMC3431132 SCOPUS ID: 2-s2.0-84863897429 04/27/2012 19 Citations

Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. (Mboko WP, Mounce BC, Wood BM, Kulinski JM, Corbett JA, Tarakanova VL) J Virol 2012 Jun;86(12):6899-912 PMID: 22496235 PMCID: PMC3393547 SCOPUS ID: 2-s2.0-84863993915 04/13/2012 22 Citations

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. (Baldwin AC, Green CD, Olson LK, Moxley MA, Corbett JA) Am J Physiol Endocrinol Metab 2012 Jun 01;302(11):E1390-8 PMID: 22436701 PMCID: PMC3378068 SCOPUS ID: 2-s2.0-84861910718 03/23/2012 56 Citations

Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. (Christmann BS, Moran JM, McGraw JA, Buller RM, Corbett JA) Am J Pathol 2011 Dec;179(6):2941-51 PMID: 22001348 PMCID: PMC3260827 SCOPUS ID: 2-s2.0-81255124282 10/18/2011 12 Citations

IRE1-dependent activation of AMPK in response to nitric oxide. (Meares GP, Hughes KJ, Naatz A, Papa FR, Urano F, Hansen PA, Benveniste EN, Corbett JA) Mol Cell Biol 2011 Nov;31(21):4286-97 PMID: 21896783 PMCID: PMC3209336 SCOPUS ID: 2-s2.0-83255187905 09/08/2011 65 Citations

Biological sensitivity to self-assembled nanomatrix platforms depends on the phenotype of MIN6 β-cells (Lim DJ, Antipenko SV, Andukuri A, Corbett JA, Jun HW) Micro and Nano Letters August 2011;6(8):619-623 SCOPUS ID: 2-s2.0-80052742728 08/01/2011 3 Citations

FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. (Hughes KJ, Meares GP, Hansen PA, Corbett JA) J Biol Chem 2011 Mar 11;286(10):8338-8348 PMID: 21196578 PMCID: PMC3048718 SCOPUS ID: 2-s2.0-79953159885 01/05/2011 52 Citations

Enhanced rat islet function and survival in vitro using a biomimetic self-assembled nanomatrix gel. (Lim DJ, Antipenko SV, Anderson JM, Jaimes KF, Viera L, Stephen BR, Bryant SM, Yancey BD, Hughes KJ, Cui W, Thompson JA, Corbett JA, Jun HW) Tissue Eng Part A 2011 Feb;17(3-4):399-406 PMID: 20807014 PMCID: PMC3028993 SCOPUS ID: 2-s2.0-79551544189 09/03/2010 28 Citations

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets. (Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T) Diabetes 2010 Oct;59(10):2360-5 PMID: 20622164 PMCID: PMC3279555 SCOPUS ID: 2-s2.0-77957580825 07/14/2010 38 Citations

Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. (Freudenburg W, Buller RM, Corbett JA) J Gen Virol 2010 Sep;91(Pt 9):2278-85 PMID: 20505008 PMCID: PMC3052521 SCOPUS ID: 2-s2.0-77956272628 05/28/2010 9 Citations

Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. (Freudenburg W, Moran JM, Lents NH, Baldassare JJ, Buller RM, Corbett JA) J Innate Immun 2010;2(1):77-86 PMID: 20375625 PMCID: PMC2943520 SCOPUS ID: 2-s2.0-77953430564 04/09/2010 12 Citations

AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death. (Meares GP, Hughes KJ, Jaimes KF, Salvatori AS, Rhodes CJ, Corbett JA) J Biol Chem 2010 Jan 29;285(5):3191-200 PMID: 19933272 PMCID: PMC2823419 SCOPUS ID: 2-s2.0-77449100323 11/26/2009 27 Citations

Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells. (Evans SA, Doblado M, Chi MM, Corbett JA, Moley KH) Endocrinology 2009 Dec;150(12):5302-10 PMID: 19808778 PMCID: PMC2795723 SCOPUS ID: 2-s2.0-71949104919 10/08/2009 45 Citations

Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage. (Hughes KJ, Chambers KT, Meares GP, Corbett JA) Am J Physiol Endocrinol Metab 2009 Nov;297(5):E1187-96 PMID: 19738038 PMCID: PMC2781357 SCOPUS ID: 2-s2.0-70350451227 09/10/2009 41 Citations

Repair of nitric oxide-damaged DNA in beta-cells requires JNK-dependent GADD45alpha expression. (Hughes KJ, Meares GP, Chambers KT, Corbett JA) J Biol Chem 2009 Oct 02;284(40):27402-8 PMID: 19648647 PMCID: PMC2785669 SCOPUS ID: 2-s2.0-70350463891 08/04/2009 34 Citations

Glucose-modulated tyrosine nitration in beta cells: targets and consequences. (Koeck T, Corbett JA, Crabb JW, Stuehr DJ, Aulak KS) Arch Biochem Biophys 2009 Apr 15;484(2):221-31 PMID: 19402213 PMCID: PMC2759311 SCOPUS ID: 2-s2.0-64749111760 04/30/2009 33 Citations

The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. (Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H) Eur J Immunol 2009 Mar;39(3):820-5 PMID: 19189309 PMCID: PMC2734089 SCOPUS ID: 2-s2.0-64049113191 02/04/2009 57 Citations

Selective mtDNA mutation accumulation results in beta-cell apoptosis and diabetes development. (Bensch KG, Mott JL, Chang SW, Hansen PA, Moxley MA, Chambers KT, de Graaf W, Zassenhaus HP, Corbett JA) Am J Physiol Endocrinol Metab 2009 Apr;296(4):E672-80 PMID: 19158322 PMCID: PMC2670628 SCOPUS ID: 2-s2.0-65649145174 01/23/2009 21 Citations

Thioredoxin-interacting protein is killing my beta-cells! (Corbett JA) Diabetes 2008 Apr;57(4):797-8 PMID: 18375442 SCOPUS ID: 2-s2.0-42449145131 04/01/2008 25 Citations

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication. (Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RML) J Gen Virol 2008 Mar;89(Pt 3):751-759 PMID: 18272767 SCOPUS ID: 2-s2.0-42449126333 02/15/2008 6 Citations

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. (Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA) Diabetes 2008 Jan;57(1):124-32 PMID: 17928398 SCOPUS ID: 2-s2.0-38449122843 10/12/2007 70 Citations

A transgenic model to study the pathogenesis of somatic mtDNA mutation accumulation in beta-cells. (Bensch KG, Degraaf W, Hansen PA, Zassenhaus HP, Corbett JA) Diabetes Obes Metab 2007 Nov;9 Suppl 2:74-80 PMID: 17919181 SCOPUS ID: 2-s2.0-35148857660 10/09/2007 11 Citations

Induction of natural killer cell responses by ectromelia virus controls infection. (Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM) J Virol 2007 Apr;81(8):4070-9 PMID: 17287257 PMCID: PMC1866162 SCOPUS ID: 2-s2.0-34247118409 02/09/2007 92 Citations

PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. (Chambers KT, Weber SM, Corbett JA) Am J Physiol Endocrinol Metab 2007 Apr;292(4):E1052-61 PMID: 17148750 SCOPUS ID: 2-s2.0-34047231566 12/07/2006 18 Citations

Metabolic disorders and inflammation (Corbett J, Mathews C) Drug Discovery Today: Disease Mechanisms 2006;3(3):365-366 SCOPUS ID: 2-s2.0-33847091691 12/01/2006 1 Citation

Type 1 diabetes: Islet inflammation - the contribution of cytokines and beta cells (Gusdon AM, Corbett JA, Mathews CE) Drug Discovery Today: Disease Mechanisms 2006;3(3):367-372 SCOPUS ID: 2-s2.0-33847189211 12/01/2006 13 Citations

Chemically chaperoning the actions of insulin. (Hansen PA, Waheed A, Corbett JA) Trends Endocrinol Metab 2007;18(1):1-3 PMID: 17116401 SCOPUS ID: 2-s2.0-33845664380 11/23/2006 8 Citations

Zinc induces ERK-dependent cell death through a specific Ras isoform. (Klein C, Creach K, Irintcheva V, Hughes KJ, Blackwell PL, Corbett JA, Baldassare JJ) Apoptosis 2006 Nov;11(11):1933-44 PMID: 17013754 SCOPUS ID: 2-s2.0-33750615090 10/03/2006 27 Citations

Insulin biosynthesis: the IREny of it all. (Corbett JA) Cell Metab 2006 Sep;4(3):175-6 PMID: 16950132 SCOPUS ID: 2-s2.0-33747839083 09/05/2006 5 Citations

Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. (Steer SA, Moran JM, Christmann BS, Maggi LB Jr, Corbett JA) J Immunol 2006 Sep 01;177(5):3413-20 PMID: 16920983 SCOPUS ID: 2-s2.0-33747756130 08/22/2006 51 Citations

Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. (Missall TA, Pusateri ME, Donlin MJ, Chambers KT, Corbett JA, Lodge JK) Eukaryot Cell 2006 Mar;5(3):518-29 PMID: 16524907 PMCID: PMC1398057 SCOPUS ID: 2-s2.0-33645054564 03/10/2006 71 Citations

Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. (Steer SA, Scarim AL, Chambers KT, Corbett JA) PLoS Med 2006 Feb;3(2):e17 PMID: 16354107 PMCID: PMC1316065 SCOPUS ID: 2-s2.0-33644843857 12/16/2005 125 Citations

Encephalomyocarditis virus induces PKR-independent mitogen-activated protein kinase activation in macrophages. (Moran JM, Moxley MA, Buller RM, Corbett JA) J Virol 2005 Aug;79(16):10226-36 PMID: 16051816 PMCID: PMC1182679 SCOPUS ID: 2-s2.0-23244467195 07/30/2005 22 Citations

Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages. (Moran JM, Buller RM, McHowat J, Turk J, Wohltmann M, Gross RW, Corbett JA) J Biol Chem 2005 Jul 29;280(30):28162-8 PMID: 15946940 SCOPUS ID: 2-s2.0-23044442059 06/11/2005 54 Citations

Incretin hormones and insulin sensitivity. (Hansen PA, Corbett JA) Trends Endocrinol Metab 2005;16(4):135-6 PMID: 15860408 SCOPUS ID: 2-s2.0-18044386757 04/30/2005 18 Citations

Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. (Missall TA, Moran JM, Corbett JA, Lodge JK) Eukaryot Cell 2005 Jan;4(1):202-8 PMID: 15643075 PMCID: PMC544170 SCOPUS ID: 2-s2.0-13744260680 01/12/2005 95 Citations

Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. (Heitmeier MR, Kelly CB, Ensor NJ, Gibson KA, Mullis KG, Corbett JA, Maziasz TJ) J Biol Chem 2004 Dec 17;279(51):53145-51 PMID: 15471850 SCOPUS ID: 2-s2.0-11144238593 10/09/2004 42 Citations

PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling. (Weber SM, Chambers KT, Bensch KG, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2004 Dec;287(6):E1171-7 PMID: 15315910 SCOPUS ID: 2-s2.0-8544267219 08/19/2004 60 Citations

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. (Mosley AL, Corbett JA, Ozcan S) Mol Endocrinol 2004 Sep;18(9):2279-90 PMID: 15166251 SCOPUS ID: 2-s2.0-4544233448 05/29/2004 101 Citations

The role and regulation of COX-2 during viral infection. (Steer SA, Corbett JA) Viral Immunol 2003;16(4):447-60 PMID: 14733733 SCOPUS ID: 2-s2.0-0347362590 01/22/2004 117 Citations

PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2004 Mar;286(3):E329-36 PMID: 14600076 SCOPUS ID: 2-s2.0-1442349764 11/06/2003 32 Citations

Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage. (Scarim AL, Nishimoto SY, Weber SM, Corbett JA) Endocrinology 2003 Aug;144(8):3415-22 PMID: 12865320 SCOPUS ID: 2-s2.0-0042315383 07/17/2003 22 Citations

Calcium-independent phospholipase A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells. (Martinson BD, Albert CJ, Corbett JA, Wysolmerski RB, Ford DA) J Lipid Res 2003 Sep;44(9):1686-91 PMID: 12810819 SCOPUS ID: 2-s2.0-0141682494 06/18/2003 22 Citations

Isolation of islets of Langerhans from rodent pancreas. (Kelly CB, Blair LA, Corbett JA, Scarim AL) Methods Mol Med 2003;83:3-14 PMID: 12619711 SCOPUS ID: 2-s2.0-0037261701 03/07/2003 46 Citations

ERK activation is required for double-stranded RNA- and virus-induced interleukin-1 expression by macrophages. (Maggi LB Jr, Moran JM, Buller RM, Corbett JA) J Biol Chem 2003 May 09;278(19):16683-9 PMID: 12609986 SCOPUS ID: 2-s2.0-0038607935 03/01/2003 35 Citations

Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. (Steer SA, Moran JM, Maggi LB Jr, Buller RM, Perlman H, Corbett JA) J Immunol 2003 Jan 15;170(2):1070-6 PMID: 12517975 SCOPUS ID: 2-s2.0-0037438348 01/09/2003 43 Citations

Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2003 May;284(5):E883-91 PMID: 12517740 SCOPUS ID: 2-s2.0-0037404327 01/09/2003 16 Citations

Novel role for calcium-independent phospholipase A(2) in the macrophage antiviral response of inducible nitric-oxide synthase expression. (Maggi LB Jr, Moran JM, Scarim AL, Ford DA, Yoon JW, McHowat J, Buller RM, Corbett JA) J Biol Chem 2002 Oct 11;277(41):38449-55 PMID: 12167650 SCOPUS ID: 2-s2.0-0037064090 08/09/2002 39 Citations

Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production. (Thomas HE, Darwiche R, Corbett JA, Kay TW) Diabetes 2002 Feb;51(2):311-6 PMID: 11812737 SCOPUS ID: 2-s2.0-0036068246 01/29/2002 154 Citations

Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets. (Blair LA, Maggi LB Jr, Scarim AL, Corbett JA) J Biol Chem 2002 Jan 04;277(1):359-65 PMID: 11694524 SCOPUS ID: 2-s2.0-0037016711 11/06/2001 34 Citations

Mechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosis. (Scarim AL, Arnush M, Blair LA, Concepcion J, Heitmeier MR, Scheuner D, Kaufman RJ, Ryerse J, Buller RM, Corbett JA) Am J Pathol 2001 Jul;159(1):273-83 PMID: 11438474 PMCID: PMC1850419 SCOPUS ID: 2-s2.0-0035408430 07/05/2001 51 Citations

Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes. (Hudson TY, Corbett JA, Howlett AC, Klein C) J Neurochem 2001 Jun;77(5):1279-84 PMID: 11389178 SCOPUS ID: 2-s2.0-0035006402 06/05/2001 12 Citations

K cells: a novel target for insulin gene therapy for the prevention of diabetes. (Corbett JA) Trends Endocrinol Metab 2001;12(4):140-2 PMID: 11295563 SCOPUS ID: 2-s2.0-0035344152 04/11/2001 12 Citations

Double-stranded RNA-dependent protein kinase is not required for double-stranded RNA-induced nitric oxide synthase expression or nuclear factor-kappaB activation by islets. (Blair LA, Heitmeier MR, Scarim AL, Maggi LB Jr, Corbett JA) Diabetes 2001 Feb;50(2):283-90 PMID: 11272138 SCOPUS ID: 2-s2.0-0035140170 03/29/2001 23 Citations

Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes. (Heitmeier MR, Arnush M, Scarim AL, Corbett JA) J Biol Chem 2001 Apr 06;276(14):11151-8 PMID: 11108714 SCOPUS ID: 2-s2.0-0035815640 12/18/2000 60 Citations

Adoptive transfer of acute lung injury. (Moxley MA, Baird TL, Corbett JA) Am J Physiol Lung Cell Mol Physiol 2000 Nov;279(5):L985-93 PMID: 11053036 SCOPUS ID: 2-s2.0-0033696812 10/29/2000 14 Citations

Potential role of PKR in double-stranded RNA-induced macrophage activation. (Maggi LB Jr, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA) EMBO J 2000 Jul 17;19(14):3630-8 PMID: 10899117 PMCID: PMC313973 SCOPUS ID: 2-s2.0-0034679589 07/19/2000 70 Citations

Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. (Maggi LB Jr, Sadeghi H, Weigand C, Scarim AL, Heitmeier MR, Corbett JA) Diabetes 2000 Mar;49(3):346-55 PMID: 10868955 SCOPUS ID: 2-s2.0-0343415083 06/27/2000 117 Citations

Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. (Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG) Cell 2000 Mar 17;100(6):645-54 PMID: 10761930 SCOPUS ID: 2-s2.0-0034677634 04/13/2000 257 Citations

Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible nitric-oxide synthase expression by islets of Langerhans. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1999 Oct 08;274(41):29266-73 PMID: 10506184 SCOPUS ID: 2-s2.0-0032832969 10/03/1999 68 Citations

Evidence that beta cell death in the nonobese diabetic mouse is Fas independent. (Thomas HE, Darwiche R, Corbett JA, Kay TW) J Immunol 1999 Aug 01;163(3):1562-9 PMID: 10415060 SCOPUS ID: 2-s2.0-0033178741 07/22/1999 108 Citations

Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1999 Apr 30;274(18):12531-6 PMID: 10212230 SCOPUS ID: 2-s2.0-0033617148 04/23/1999 29 Citations

Nitric oxide participates in early events associated with NNMU-induced acute lung injury in rats. (Cruz WS, Corbett JA, Longmore WJ, Moxley MA) Am J Physiol 1999 Feb;276(2):L263-8 PMID: 9950888 SCOPUS ID: 2-s2.0-0033024262 02/10/1999 7 Citations

Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets. (Scarim AL, Heitmeier MR, Corbett JA) Endocrinology 1998 Dec;139(12):5050-7 PMID: 9832444 SCOPUS ID: 2-s2.0-0031757110 12/01/1998 103 Citations

Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion. (Parkkila AK, Scarim AL, Parkkila S, Waheed A, Corbett JA, Sly WS) J Biol Chem 1998 Sep 18;273(38):24620-3 PMID: 9733757 SCOPUS ID: 2-s2.0-0032544429 09/12/1998 64 Citations

IL-1 produced and released endogenously within human islets inhibits beta cell function. (Arnush M, Heitmeier MR, Scarim AL, Marino MH, Manning PT, Corbett JA) J Clin Invest 1998 Aug 01;102(3):516-26 PMID: 9691088 PMCID: PMC508912 SCOPUS ID: 2-s2.0-0032146564 08/06/1998 219 Citations

Double-stranded RNA-induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1998 Jun 12;273(24):15301-7 PMID: 9614147 SCOPUS ID: 2-s2.0-0032511096 06/17/1998 97 Citations

Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. (Kwon G, Corbett JA, Hauser S, Hill JR, Turk J, McDaniel ML) Diabetes 1998 Apr;47(4):583-91 PMID: 9568691 SCOPUS ID: 2-s2.0-0031899972 05/06/1998 76 Citations

Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. (Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA) J Immunol 1998 Mar 15;160(6):2684-91 PMID: 9510167 SCOPUS ID: 2-s2.0-0032521025 03/24/1998 130 Citations

Inhibition of nitric oxide synthase attenuates NNMU-induced alveolar injury in vivo. (Cruz WS, Moxley MA, Corbett JA, Longmore WJ) Am J Physiol 1997 Dec;273(6):L1167-73 PMID: 9435571 SCOPUS ID: 2-s2.0-0031408789 01/22/1998 14 Citations

Evidence for the presence of type I IL-1 receptors on beta-cells of islets of Langerhans. (Scarim AL, Arnush M, Hill JR, Marshall CA, Baldwin A, McDaniel ML, Corbett JA) Biochim Biophys Acta 1997 Oct 24;1361(3):313-20 PMID: 9375806 SCOPUS ID: 2-s2.0-0030667121 12/31/1997 31 Citations

Irreversible inhibition of metabolic function and islet destruction after a 36-hour exposure to interleukin-1beta. (Scarim AL, Heitmeier MR, Corbett JA) Endocrinology 1997 Dec;138(12):5301-7 PMID: 9389514 SCOPUS ID: 2-s2.0-0030684124 12/06/1997 66 Citations

Pyruvate carboxylase, a role in insulin secretion? (Xu B, Crist GH, Sly WS, Waheed A, Parkkila S, Parkkila AK, Corbett J, Scarim A, Lynch CJ, LaNoue KF) FASEB Journal 1997;11(3) SCOPUS ID: 2-s2.0-33750102876 12/01/1997

Beta-cell ontogeny: growth and death. (Corbett J, Serup P, Bonner-Weir S, Nielsen JH) Diabetologia 1997 Oct;40 Suppl 3:B27-32 PMID: 9345642 SCOPUS ID: 2-s2.0-0030763486 11/05/1997 27 Citations

Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets. (Kwon G, Hill JR, Corbett JA, McDaniel ML) Mol Pharmacol 1997 Sep;52(3):398-405 PMID: 9281601 SCOPUS ID: 2-s2.0-0030818461 09/01/1997 51 Citations

Phorbol esters stimulate muscle glucose transport by a mechanism distinct from the insulin and hypoxia pathways. (Hansen PA, Corbett JA, Holloszy JO) Am J Physiol 1997 Jul;273(1 Pt 1):E28-36 PMID: 9252476 SCOPUS ID: 2-s2.0-0030858852 07/01/1997 40 Citations

Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1. (Heitmeier MR, Scarim AL, Corbett JA) J Biol Chem 1997 May 23;272(21):13697-704 PMID: 9153221 SCOPUS ID: 2-s2.0-0030997703 05/23/1997 143 Citations

Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. (Carroll SL, Miller ML, Frohnert PW, Kim SS, Corbett JA) J Neurosci 1997 Mar 01;17(5):1642-59 PMID: 9030624 PMCID: PMC6573392 SCOPUS ID: 2-s2.0-0031039847 03/01/1997 291 Citations

A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction. (McDaniel ML, Corbett JA, Kwon G, Hill JR) Adv Exp Med Biol 1997;426:313-9 PMID: 9544288 SCOPUS ID: 2-s2.0-0001462775 01/01/1997 42 Citations

A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic β-cell dysfunction and destruction (McDaniel ML, Corbett JA, Kwon G, Hill JR) Advances in Experimental Medicine and Biology 1997;426:313-319 SCOPUS ID: 2-s2.0-0001462775 01/01/1997 43 Citations

Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells. (Meredith M, Rabaglia ME, Corbett JA, Metz SA) Diabetes 1996 Dec;45(12):1783-91 PMID: 8922366 SCOPUS ID: 2-s2.0-0029967888 12/01/1996 24 Citations

Nitric oxide regulates interleukin 1 bioactivity released from murine macrophages. (Hill JR, Corbett JA, Kwon G, Marshall CA, McDaniel ML) J Biol Chem 1996 Sep 13;271(37):22672-8 PMID: 8798439 SCOPUS ID: 2-s2.0-0029811755 09/13/1996 56 Citations

The Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes. (Corbett JA, McDaniel ML) Methods 1996 Aug;10(1):21-30 PMID: 8812641 SCOPUS ID: 2-s2.0-0030220093 08/01/1996 49 Citations

Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets. (Corbett JA, Kwon G, Marino MH, Rodi CP, Sullivan PM, Turk J, McDaniel ML) Am J Physiol 1996 Jun;270(6 Pt 1):C1581-7 PMID: 8764139 SCOPUS ID: 2-s2.0-0029745336 06/01/1996 90 Citations

Nitric oxide production by the rat insulinoma cell line, RINm5F, Is specific for IL-1: a spectrophotometric IL-1 bioassay. (Hill JR, Corbett JA, Baldwin AC, McDaniel ML) Anal Biochem 1996 Apr 05;236(1):14-9 PMID: 8619479 SCOPUS ID: 2-s2.0-0029875376 04/05/1996 18 Citations

Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide. (Kwon G, Bohrer A, Han X, Corbett JA, Ma Z, Gross RW, McDaniel ML, Turk J) Biochim Biophys Acta 1996 Mar 29;1300(1):63-72 PMID: 8608164 SCOPUS ID: 2-s2.0-0029975884 03/29/1996 23 Citations

Interleukin 1-induced Fos and Jun do not regulate inducible nitric oxide synthase in rat islets of Langerhans and RINm5F cells. (Kwon G, Corbett JA, McDaniel ML) Endocrinology 1996 Mar;137(3):825-30 PMID: 8603591 SCOPUS ID: 2-s2.0-0030028210 03/01/1996 14 Citations

Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase. (Zhao W, Tilton RG, Corbett JA, McDaniel ML, Misko TP, Williamson JR, Cross AH, Hickey WF) J Neuroimmunol 1996 Feb;64(2):123-33 PMID: 8632054 SCOPUS ID: 2-s2.0-0029871609 02/01/1996 137 Citations

Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism. (Ma Z, Ramanadham S, Corbett JA, Bohrer A, Gross RW, McDaniel ML, Turk J) J Biol Chem 1996 Jan 12;271(2):1029-42 PMID: 8557627 SCOPUS ID: 2-s2.0-0030042403 01/12/1996 58 Citations

Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. (Denlinger LC, Fisette PL, Garis KA, Kwon G, Vazquez-Torres A, Simon AD, Nguyen B, Proctor RA, Bertics PJ, Corbett JA) J Biol Chem 1996 Jan 05;271(1):337-42 PMID: 8550583 SCOPUS ID: 2-s2.0-13344284662 01/05/1996 156 Citations

Selective inhibition of inducible nitric oxide synthase by aminoguanidine. (Corbett JA, McDaniel ML) Methods Enzymol 1996;268:398-408 PMID: 8782606 SCOPUS ID: 2-s2.0-0029847981 01/01/1996 46 Citations

Cytokines and nitric oxide in islet inflammation and diabetes. (McDaniel ML, Kwon G, Hill JR, Marshall CA, Corbett JA) Proc Soc Exp Biol Med 1996 Jan;211(1):24-32 PMID: 8594615 SCOPUS ID: 2-s2.0-0030030057 01/01/1996 234 Citations

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. (Kwon G, Corbett JA, Rodi CP, Sullivan P, McDaniel ML) Endocrinology 1995 Nov;136(11):4790-5 PMID: 7588208 SCOPUS ID: 2-s2.0-0028973284 11/01/1995 160 Citations

Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. (Corbett JA, McDaniel ML) J Exp Med 1995 Feb 01;181(2):559-68 PMID: 7530759 PMCID: PMC2191862 SCOPUS ID: 2-s2.0-0028900805 02/01/1995 236 Citations

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans. (Corbett JA, Kwon G, Misko TP, Rodi CP, McDaniel ML) Am J Physiol 1994 Jul;267(1 Pt 1):C48-54 PMID: 7519400 SCOPUS ID: 2-s2.0-0028112591 07/01/1994 81 Citations

Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. (Tilton RG, Chang K, Corbett JA, Misko TP, Currie MG, Bora NS, Kaplan HJ, Williamson JR) Invest Ophthalmol Vis Sci 1994 Jul;35(8):3278-88 PMID: 7519183 SCOPUS ID: 2-s2.0-0028141504 07/01/1994 111 Citations

Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. (Corbett JA, McDaniel ML) Biochem J 1994 May 01;299 ( Pt 3)(Pt 3):719-24 PMID: 7514870 PMCID: PMC1138079 SCOPUS ID: 2-s2.0-0028181046 05/01/1994 86 Citations

Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface. (Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santiago JV, McDaniel ML) Diabetes 1994 Mar;43(3):418-25 PMID: 8314014 SCOPUS ID: 2-s2.0-0028140001 03/01/1994 30 Citations

Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis. (Heiss LN, Lancaster JR Jr, Corbett JA, Goldman WE) Proc Natl Acad Sci U S A 1994 Jan 04;91(1):267-70 PMID: 7506415 PMCID: PMC42928 SCOPUS ID: 2-s2.0-0028047687 01/04/1994 139 Citations

Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. (Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML) Biochem Biophys Res Commun 1993 Dec 30;197(3):1458-64 PMID: 7904159 SCOPUS ID: 2-s2.0-0027739947 12/30/1993 187 Citations

Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes. (Hewett SJ, Corbett JA, McDaniel ML, Choi DW) Neurosci Lett 1993 Dec 24;164(1-2):229-32 PMID: 7512249 SCOPUS ID: 2-s2.0-0027787430 12/24/1993 108 Citations

IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. (Corbett JA, Kwon G, Turk J, McDaniel ML) Biochemistry 1993 Dec 21;32(50):13767-70 PMID: 7505613 SCOPUS ID: 2-s2.0-0027788115 12/21/1993 250 Citations

Nitric oxide mediates interleukin-1-induced cellular cytotoxicity in the rat ovary. A potential role for nitric oxide in the ovulatory process. (Ellman C, Corbett JA, Misko TP, McDaniel M, Beckerman KP) J Clin Invest 1993 Dec;92(6):3053-6 PMID: 7504698 PMCID: PMC288511 SCOPUS ID: 2-s2.0-0027143191 12/01/1993 156 Citations

Inhibition of nitric oxide formation by guanidines. (Hasan K, Heesen BJ, Corbett JA, McDaniel ML, Chang K, Allison W, Wolffenbuttel BH, Williamson JR, Tilton RG) Eur J Pharmacol 1993 Nov 02;249(1):101-6 PMID: 7506664 SCOPUS ID: 2-s2.0-0027374229 11/02/1993 166 Citations

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity. (Hewett SJ, Corbett JA, McDaniel ML, Choi DW) Brain Res 1993 Oct 22;625(2):337-41 PMID: 8275317 SCOPUS ID: 2-s2.0-0027376374 10/22/1993 71 Citations

Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process. (Corbett JA, Mikhael A, Shimizu J, Frederick K, Misko TP, McDaniel ML, Kanagawa O, Unanue ER) Proc Natl Acad Sci U S A 1993 Oct 01;90(19):8992-5 PMID: 7692442 PMCID: PMC47487 SCOPUS ID: 2-s2.0-0027489210 10/01/1993 154 Citations

Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia--effect of diabetes and aging. (Schmidt RE, Dorsey DA, McDaniel ML, Corbett JA) Brain Res 1993 Jul 23;617(2):343-8 PMID: 8104662 SCOPUS ID: 2-s2.0-0027183822 07/23/1993 20 Citations

What are the types and cellular sources of free radicals in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus? (Mandrup-Poulsen T, Corbett JA, McDaniel ML, Nerup J) Diabetologia 1993 May;36(5):470-1 PMID: 7686111 SCOPUS ID: 2-s2.0-0027243274 05/01/1993 33 Citations

Glucose-induced insulin secretion from purified beta-cells. A role for modulation of Ca2+ influx by cAMP- and protein kinase C-dependent signal transduction pathways. (Wang JL, Corbett JA, Marshall CA, McDaniel ML) J Biol Chem 1993 Apr 15;268(11):7785-91 PMID: 8385120 SCOPUS ID: 2-s2.0-0027418326 04/15/1993 57 Citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. (Misko TP, Moore WM, Kasten TP, Nickols GA, Corbett JA, Tilton RG, McDaniel ML, Williamson JR, Currie MG) Eur J Pharmacol 1993 Mar 16;233(1):119-25 PMID: 7682510 SCOPUS ID: 2-s2.0-0027402115 03/16/1993 715 Citations

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. (Corbett JA, Sweetland MA, Wang JL, Lancaster JR Jr, McDaniel ML) Proc Natl Acad Sci U S A 1993 Mar 01;90(5):1731-5 PMID: 8383325 PMCID: PMC45953 SCOPUS ID: 2-s2.0-0027534895 03/01/1993 411 Citations

Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. (Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML) Diabetes 1993 Feb;42(2):221-32 PMID: 7678825 SCOPUS ID: 2-s2.0-0027400644 02/01/1993 320 Citations

A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism. (Corbett JA, Sweetland MA, Lancaster JR Jr, McDaniel ML) FASEB J 1993 Feb 01;7(2):369-74 PMID: 8440413 SCOPUS ID: 2-s2.0-0027403306 02/01/1993 74 Citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. (Beckerman KP, Rogers HW, Corbett JA, Schreiber RD, McDaniel ML, Unanue ER) J Immunol 1993 Feb 01;150(3):888-95 PMID: 7678626 SCOPUS ID: 2-s2.0-0027273290 02/01/1993 248 Citations

Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone. (Corbett JA, Wang JL, Misko TP, Zhao W, Hickey WF, McDaniel ML) Autoimmunity 1993;15(2):145-53 PMID: 7692996 SCOPUS ID: 2-s2.0-0027301777 01/01/1993 84 Citations

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. (Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr, McDaniel ML) J Clin Invest 1992 Dec;90(6):2384-91 PMID: 1334975 PMCID: PMC443394 SCOPUS ID: 2-s2.0-0027054055 12/11/1992 308 Citations

Nitric oxide and cyclic GMP formation induced by interleukin 1 beta in islets of Langerhans. Evidence for an effector role of nitric oxide in islet dysfunction. (Corbett JA, Wang JL, Hughes JH, Wolf BA, Sweetland MA, Lancaster JR Jr, McDaniel ML) Biochem J 1992 Oct 01;287 ( Pt 1)(Pt 1):229-35 PMID: 1384465 PMCID: PMC1133148 SCOPUS ID: 2-s2.0-0026793534 10/11/1992 141 Citations

Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. (Corbett JA, McDaniel ML) Diabetes 1992 Aug;41(8):897-903 PMID: 1378415 SCOPUS ID: 2-s2.0-0026683354 08/01/1992 359 Citations

Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. (Corbett JA, Tilton RG, Chang K, Hasan KS, Ido Y, Wang JL, Sweetland MA, Lancaster JR Jr, Williamson JR, McDaniel ML) Diabetes 1992 Apr;41(4):552-6 PMID: 1376704 SCOPUS ID: 2-s2.0-0026641944 04/11/1992 638 Citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. (Corbett JA, Lancaster JR Jr, Sweetland MA, McDaniel ML) J Biol Chem 1991 Nov 15;266(32):21351-4 PMID: 1657959 SCOPUS ID: 2-s2.0-0025720502 11/25/1991 279 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

John A. Corbett PhD

Chair, Professor

Publications (180)