Faculty Collaboration Database

Dipyridamole-induced decrement of functional recovery of postischemic reperfused myocardium in conscious dogs with well-developed coronary collateral circulation. Am Heart J 1991 May;121(5):1339-47

Date

05/01/1991

Pubmed ID

2017968

DOI

10.1016/0002-8703(91)90136-6

Scopus ID

2-s2.0-0025761914 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

The effects of dipyridamole (20 and 40 micrograms/kg/min intravenously) on the time course of functional recovery of myocardium after five 5-minute coronary artery occlusions and four 5-minute reperfusions and a subsequent 5-hour reperfusion period were studied in chronically instrumented, conscious dogs with well-developed coronary collateral circulation. In comparison with vehicle-treated control dogs, those given dipyridamole (20 and 40 micrograms/kg/min, respectively) 15 minutes before and during coronary occlusion had a greater depression of regional segment shortening (38 +/- 7% and 19 +/- 4%, respectively, vs control levels of 69 +/- 10% of preocclusion values) during acute coronary artery occlusion. After a 5-hour reperfusion period, segment shortening returned to preocclusion values in the control group but remained decreased in the dipyridamole groups (87 +/- 4% and 75%, respectively). These results suggest that dipyridamole in a dose-dependent manner exacerbates recovery of contractility of postischemic reperfused myocardium in dogs with well-developed coronary collateral circulation.

Author List

Kenny D, Wynsen JC, Brooks HL, Warltier DC

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Collateral Circulation
Coronary Circulation
Depression, Chemical
Dipyridamole
Dogs
Dose-Response Relationship, Drug
Female
Male
Myocardial Contraction
Myocardial Reperfusion
Myocardial Reperfusion Injury
Time Factors