Comparative effects of inotropic agents on coronary and systemic hemodynamics of conscious dogs: actions of milrinone, dopamine, ouabain and MCI-154. Pharmacology 1988;36(4):217-27
Date
01/01/1988Pubmed ID
3380877DOI
10.1159/000138388Scopus ID
2-s2.0-0023832485 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
The hemodynamic actions of a new inotropic agent, MCI-154, were compared to dopamine, ouabain and milrinone in conscious, chronically instrumented dogs. MCI-154 and milrinone produced similar hemodynamic changes: increases in heart rate, diastolic coronary blood flow velocity and peak positive dP/dt. Neither agent had significant effects on arterial pressure while both drugs reduced left ventricular end-diastolic pressure in a dose-related fashion and myocardial segment length, indicating a decrease in diastolic left-ventricular size. MCI-154 was found to be approximately twice as potent as milrinone. In contrast, dopamine and ouabain produced little change in left ventricular end-diastolic pressure or myocardial segment length during diastole, while both drugs produced increases in arterial and left ventricular systolic pressures. An increase in left ventricular afterload was not observed with either MCI-154 or milrinone, highlighting an important advantage of the latter compounds.
Author List
Al-Wathiqui MH, Shimshak TM, Brooks HL, Preuss KC, Wynsen JC, Gross GJ, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsBlood Flow Velocity
Blood Pressure
Cardiotonic Agents
Coronary Circulation
Dogs
Dopamine
Female
Heart Rate
Hemodynamics
Male
Milrinone
Myocardial Contraction
Ouabain
Pyridazines
Pyridones
Vascular Resistance
