Roles of transient receptor potential channels in pain. Brain Res Rev 2009 Apr;60(1):2-23
Date
02/11/2009Pubmed ID
19203589Pubmed Central ID
PMC2683630DOI
10.1016/j.brainresrev.2008.12.018Scopus ID
2-s2.0-63649152092 (requires institutional sign-in at Scopus site) 160 CitationsAbstract
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in somatosensory nociceptors. Here we highlight the roles of TRP vanilloid 1 (TRPV1), TRP melastatin 8 (TRPM8) and TRP ankyrin 1 (TRPA1) in the activation of nociceptors by heat and cold environmental stimuli, mechanical force, and by chemicals including exogenous plant and environmental compounds as well as endogenous inflammatory molecules. The contribution of these channels to pain and somatosensation is discussed at levels ranging from whole animal behavior to molecular modulation by intracellular signaling proteins. An emerging theme is that TRP channels are not simple ion channel transducers of one or two stimuli, but instead serve multidimensional roles in signaling sensory stimuli that are exceptionally diverse in modality and in their environmental milieu.
Author List
Stucky CL, Dubin AE, Jeske NA, Malin SA, McKemy DD, Story GMAuthor
Cheryl L. Stucky PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnkyrins
Humans
Nervous System
Nociceptors
Pain
Sensation
Sensory Receptor Cells
Signal Transduction
TRPM Cation Channels
TRPV Cation Channels
Transient Receptor Potential Channels
