MicroRNA: a new frontier in kidney and blood pressure research. Am J Physiol Renal Physiol 2009 Sep;297(3):F553-8
Date
04/03/2009Pubmed ID
19339633Pubmed Central ID
PMC2739705DOI
10.1152/ajprenal.00045.2009Scopus ID
2-s2.0-67650259138 (requires institutional sign-in at Scopus site) 92 CitationsAbstract
MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be functionally important in models of diabetic nephropathy, podocyte development, and polycystic disease. miRNAs may be involved in the regulation of arterial blood pressure, including possible involvement in genetic elements of hypertension. Studies of miRNAs could generate diagnostic biomarkers for kidney disease and new mechanistic insights into the complex regulatory networks underlying kidney disease and hypertension. Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation.
Author List
Liang M, Liu Y, Mladinov D, Cowley AW Jr, Trivedi H, Fang Y, Xu X, Ding X, Tian ZAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Gene Expression Regulation
Genetic Markers
Humans
Hypertension
Kidney Diseases
MicroRNAs
