Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary. Cell Immunol 1995 Jan;160(1):14-23
Date
01/01/1995Pubmed ID
7842480DOI
10.1016/0008-8749(95)80004-3Scopus ID
2-s2.0-0028939267 (requires institutional sign-in at Scopus site) 53 CitationsAbstract
Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that interleukin-2 (IL2)- and IL4-dependent proliferation of HT-2 T lymphocytes is equally inhibited. apoE has no effect on IL2-augmented killing of target cells by cytotoxic T cells, indicating that it has no direct effect on signaling via interleukin receptors. The data are consistent with inhibition by apoE of an event or pathway distal to receptor signaling and required for G1A transition, or G1B entry.
Author List
Mistry MJ, Clay MA, Kelly ME, Steiner MA, Harmony JAMESH terms used to index this publication - Major topics in bold
AnimalsApolipoproteins E
Cells, Cultured
Cytotoxicity, Immunologic
G1 Phase
Humans
Interleukin-2
Interleukin-4
Lymphocyte Activation
Mice
Receptors, Interleukin-2
Signal Transduction
T-Lymphocytes
