Faculty Collaboration Database

Preferential increase in subendocardial perfusion produced by endothelium-dependent vasodilators. Circulation 1987 Jul;76(1):191-200

Date

07/01/1987

Pubmed ID

3594767

DOI

10.1161/01.cir.76.1.191

Scopus ID

2-s2.0-0023278756 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

The transmural distribution of myocardial blood flow across the left ventricles of anesthetized dogs was measured with radioactive microspheres during intracoronary infusion of the endothelium-dependent vasodilators acetylcholine (10 micrograms/min), adenosine triphosphate (ATP; 20 micrograms/min), and arachidonic acid (600 micrograms/min) and the endothelium-independent vasodilator nifedipine (5 micrograms/min). These compounds were administered before and after a 30 min intracoronary infusion of the phospholipase A2 inhibitor quinacrine (300 micrograms/min). Acetylcholine, ATP, and arachidonic acid produced significant (p less than .05) increases in transmural blood flow and in the ratio of subendocardial to subepicardial blood flow (endo/epi) when compared with control. Infusion of quinacrine did not affect this ratio and did not block the increase in transmural blood flow produced by each agent; however, it did block the redistribution of flow to the subendocardium. In contrast, there was no change in endo/epi during intracoronary infusion of nifedipine before and after quinacrine. These results suggest that endothelium-dependent vasodilators produce a preferential increase in subendocardial perfusion via a product of unsaturated fatty acid metabolism.

Author List

Pelc LR, Gross GJ, Warltier DC

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Coronary Circulation
Dogs
Endocardium
Endothelium
Female
Hemodynamics
Male
Phospholipases A
Phospholipases A2
Quinacrine
Regional Blood Flow
Vasodilator Agents