Immune response among patients exposed to molds. Int J Mol Sci 2009 Dec 21;10(12):5471-84
Date
01/08/2010Pubmed ID
20054481Pubmed Central ID
PMC2802005DOI
10.3390/ijms10125471Scopus ID
2-s2.0-74249098660 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.
Author List
Edmondson DA, Barrios CS, Brasel TL, Straus DC, Kurup VP, Fink JNMESH terms used to index this publication - Major topics in bold
Adaptive ImmunityAdolescent
Adult
Case-Control Studies
Cell Proliferation
Child
Environmental Exposure
Environmental Illness
Female
Humans
Immunoglobulins
Male
Middle Aged
Skin Tests
Stachybotrys
T-Lymphocytes
Trichothecenes
