The role of glutathione in the transport and catabolism of nitric oxide. FEBS Lett 1996 Mar 18;382(3):223-8
Date
03/18/1996Pubmed ID
8605974DOI
10.1016/0014-5793(96)00086-5Scopus ID
2-s2.0-0029927487 (requires institutional sign-in at Scopus site) 252 CitationsAbstract
Nitric oxide acts as a neuronal and vascular messenger implying diffusion through intracellular environments containing 5-10 mM glutathione. Nitric oxide reacts with glutathione under aerobic conditions generating S-nitrosoglutathione (GSNO). GSNO reacts with glutathione (k= 8.3 X 10(-3) M-1 X s-1) to generate nitrous oxide and glutathione disulfide (GSSG). Anaerobically, glutathione reacts with nitric oxide generating nitrous oxide and GSSG (k= 4.8 X 10(-4) s-1 at 5 mM GSH). In both aerobic and anaerobic situations the nitroxyl anion may be an intermediate in the synthesis of nitrous oxide and, under aerobic conditions, nitroxyl anion may generate peroxynitrite. We present a hypothesis for the intracellular interaction between nitric oxide and glutathione.
Author List
Hogg N, Singh RJ, Kalyanaraman BAuthors
Neil Hogg PhD Sr Associate Dean, Professor in the Biophysics department at Medical College of WisconsinBalaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AerobiosisAnaerobiosis
Biological Transport
Glutathione
Glutathione Disulfide
Kinetics
Models, Chemical
Nitric Oxide
Nitroso Compounds
S-Nitrosoglutathione
