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Balaraman Kalyanaraman PhD

Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Research

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Neuroscience Research Center

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Publications (444)

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson's disease. (Ay M, Charli A, Langley M, Jang A, Padhi P, Jin H, Anantharam V, Kalyanaraman B, Kanthasamy A, Kanthasamy AG) Front Neurosci 2024;18:1356703 PMID: 38449738 PMCID: PMC10915001 SCOPUS ID: 2-s2.0-85186547752 03/07/2024

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications. (Kalyanaraman B, Cheng G, Hardy M) Redox Biol 2024 May;71:103092 PMID: 38377788 PMCID: PMC10891329 SCOPUS ID: 2-s2.0-85185575430 02/21/2024

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells. (Xiong D, Yin Z, Huang M, Wang Y, Hardy M, Kalyanaraman B, Wong ST, You M) Cancer Commun (Lond) 2024 Mar;44(3):448-452 PMID: 37930151 PMCID: PMC10958673 SCOPUS ID: 2-s2.0-85176136734 11/06/2023

OXPHOS-targeting drugs in oncology: new perspectives. (Kalyanaraman B, Cheng G, Hardy M, You M) Expert Opin Ther Targets 2023;27(10):939-952 PMID: 37736880 PMCID: PMC11034819 SCOPUS ID: 2-s2.0-85173986031 09/22/2023 3 Citations

Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies. (Cheng G, Karoui H, Hardy M, Kalyanaraman B) Free Radic Biol Med 2023 Aug 20;205:175-187 PMID: 37321281 SCOPUS ID: 2-s2.0-85162228734 06/16/2023 1 Citation

Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells. (Cheng G, Hardy M, Kalyanaraman B) Sci Rep 2023 May 04;13(1):7254 PMID: 37142668 PMCID: PMC10160116 SCOPUS ID: 2-s2.0-85158068757 05/05/2023 2 Citations

Polyphenolic Boronates Inhibit Tumor Cell Proliferation: Potential Mitigators of Oxidants in the Tumor Microenvironment. (Cheng G, Karoui H, Hardy M, Kalyanaraman B) Cancers (Basel) 2023 Feb 08;15(4) PMID: 36831432 PMCID: PMC9953882 SCOPUS ID: 2-s2.0-85149107017 02/26/2023 1 Citation

NAC, NAC, Knockin' on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells. (Kalyanaraman B) Redox Biol 2022 Nov;57:102497 PMID: 36242913 PMCID: PMC9563555 SCOPUS ID: 2-s2.0-85139734287 10/16/2022 18 Citations

The Chemistry of HNO: Mechanisms and Reaction Kinetics. (Michalski R, Smulik-Izydorczyk R, Pięta J, Rola M, Artelska A, Pierzchała K, Zielonka J, Kalyanaraman B, Sikora AB) Front Chem 2022;10:930657 PMID: 35864868 PMCID: PMC9294461 SCOPUS ID: 2-s2.0-85134235413 07/23/2022 3 Citations

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities. (Kalyanaraman B, Cheng G, Hardy M) Front Oncol 2022;12:816504 PMID: 35756631 PMCID: PMC9214210 SCOPUS ID: 2-s2.0-85133350425 06/28/2022 10 Citations

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. (Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B) Nat Metab 2022 Jun;4(6):651-662 PMID: 35760871 PMCID: PMC9711940 SCOPUS ID: 2-s2.0-85132951828 06/28/2022 364 Citations

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds. (Zhang Q, Xiong D, Pan J, Wang Y, Hardy M, Kalyanaraman B, You M) Cancers (Basel) 2022 May 21;14(10) PMID: 35626143 PMCID: PMC9140024 SCOPUS ID: 2-s2.0-85130231561 05/29/2022 7 Citations

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation. (Cheng G, Hardy M, You M, Kalyanaraman B) Sci Rep 2022 Mar 24;12(1):5143 PMID: 35332210 PMCID: PMC8948292 SCOPUS ID: 2-s2.0-85127039662 03/26/2022 8 Citations

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone. (Huang M, Xiong D, Pan J, Zhang Q, Wang Y, Myers CR, Johnson BD, Hardy M, Kalyanaraman B, You M) Adv Sci (Weinh) 2022 Apr;9(12):e2101267 PMID: 35243806 PMCID: PMC9036031 SCOPUS ID: 2-s2.0-85125564839 03/05/2022 17 Citations

Exploiting the tumor immune microenvironment and immunometabolism using mitochondria-targeted drugs: Challenges and opportunities in racial disparity and cancer outcome research. (Kalyanaraman B) FASEB J 2022 Apr;36(4):e22226 PMID: 35233843 PMCID: PMC9242412 SCOPUS ID: 2-s2.0-85125582482 03/03/2022 6 Citations

Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction (Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B) Journal of Biomedical Materials Research - Part B Applied Biomaterials February 2022;110(2):450-459 SCOPUS ID: 2-s2.0-85111244735 02/01/2022 9 Citations

Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: overlapping biology with cancer. (Kalyanaraman B) RSC Chem Biol 2021 Oct 07;2(5):1402-1414 PMID: 34704045 PMCID: PMC8496060 SCOPUS ID: 2-s2.0-85116898742 10/28/2021 8 Citations

Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders. (Chelimsky G, Simpson P, Zhang L, Bierer D, Komas S, Kalyanaraman B, Chelimsky T) Pain Res Manag 2021;2021:6627864 PMID: 34426756 PMCID: PMC8380178 SCOPUS ID: 2-s2.0-85113790316 08/25/2021 1 Citation

On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence (Siarkiewicz P, Michalski R, Sikora A, Smulik-Izydorczyk R, Szala M, Grzelakowska A, Modrzejewska J, Bailey A, Nycz JE, Kalyanaraman B, Malecki JG, Zielonka J, Podsiadły R) Dyes and Pigments August 2021;192 SCOPUS ID: 2-s2.0-85105322458 08/01/2021 12 Citations

Functionalized polyanhydride nanoparticles for improved treatment of mitochondrial dysfunction. (Schlichtmann BW, Kalyanaraman B, Schlichtmann RL, Panthani MG, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B) J Biomed Mater Res B Appl Biomater 2022 Feb;110(2):450-459 PMID: 34312984 SCOPUS ID: 2-s2.0-85111244735 07/28/2021 9 Citations

Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects. (Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B) iScience 2021 Jun 25;24(6):102673 PMID: 34189437 PMCID: PMC8215227 SCOPUS ID: 2-s2.0-85107809306 07/01/2021 16 Citations

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression. (AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB) iScience 2021 Jun 25;24(6):102653 PMID: 34189432 PMCID: PMC8220235 SCOPUS ID: 2-s2.0-85107963806 07/01/2021 18 Citations

Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid. (Zielonka J, Sikora A, Podsiadly R, Hardy M, Kalyanaraman B) Methods Mol Biol 2021;2275:315-327 PMID: 34118047 PMCID: PMC9245525 SCOPUS ID: 2-s2.0-85108205869 06/13/2021 8 Citations

Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology. (Brown SA, Zaharova S, Mason P, Thompson J, Thapa B, Ishizawar D, Wilkes E, Ahmed G, Rubenstein J, Sanchez J, Joyce D, Kalyanaraman B, Widlansky M) Front Cardiovasc Med 2020;7:568720 PMID: 33344513 PMCID: PMC7746643 SCOPUS ID: 2-s2.0-85115906217 12/22/2020 5 Citations

Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide. (Michalski R, Thiebaut D, Michałowski B, Ayhan MM, Hardy M, Ouari O, Rostkowski M, Smulik-Izydorczyk R, Artelska A, Marcinek A, Zielonka J, Kalyanaraman B, Sikora A) Sci Rep 2020 Oct 29;10(1):18626 PMID: 33122809 PMCID: PMC7596101 SCOPUS ID: 2-s2.0-85094638056 10/31/2020 13 Citations

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. (Sikora A, Zielonka J, Dębowska K, Michalski R, Smulik-Izydorczyk R, Pięta J, Podsiadły R, Artelska A, Pierzchała K, Kalyanaraman B) Front Chem 2020;8:580899 PMID: 33102447 PMCID: PMC7545953 SCOPUS ID: 2-s2.0-85092384929 10/27/2020 45 Citations

Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone. (Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B) Sci Rep 2020 Oct 21;10(1):17872 PMID: 33087770 PMCID: PMC7578061 SCOPUS ID: 2-s2.0-85093870747 10/23/2020 30 Citations

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. (Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle KA, Abu Eid M, McAllister D, Bennett B, Kresty LA, Dwinell MB, Kalyanaraman B) Cancer Treat Res Commun 2020;25:100210 PMID: 32987287 PMCID: PMC7883397 SCOPUS ID: 2-s2.0-85091576205 09/29/2020 19 Citations

Do free radical NETwork and oxidative stress disparities in African Americans enhance their vulnerability to SARS-CoV-2 infection and COVID-19 severity? (Kalyanaraman B) Redox Biol 2020 Oct;37:101721 PMID: 32961440 PMCID: PMC7490257 SCOPUS ID: 2-s2.0-85091070172 09/23/2020 16 Citations

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's disease. (Kalyanaraman B) Redox Biol 2020 Sep;36:101665 PMID: 32795938 PMCID: PMC7426584 SCOPUS ID: 2-s2.0-85089281502 08/17/2020 25 Citations

Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids. (Angireddy R, Chowdhury AR, Zielonka J, Ruthel G, Kalyanaraman B, Avadhani NG) Free Radic Biol Med 2020 Nov 01;159:1-14 PMID: 32738395 SCOPUS ID: 2-s2.0-85089013403 08/02/2020 15 Citations

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon. (Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG) Redox Biol 2020 Sep;36:101606 PMID: 32604037 PMCID: PMC7327929 SCOPUS ID: 2-s2.0-85086919803 07/01/2020 57 Citations

XIth EPR Workshop on Applications of EPR in Biology and Medicine (Berliner L, Sarna T, Kalyanaraman B) Cell Biochemistry and Biophysics 1 June 2020;78(2):121-122 SCOPUS ID: 2-s2.0-85085293149 06/01/2020

XIth EPR Workshop on Applications of EPR in Biology and Medicine. (Berliner L, Sarna T, Kalyanaraman B) Cell Biochem Biophys 2020 Jun;78(2):121-122 PMID: 32449076 SCOPUS ID: 2-s2.0-85085293149 05/26/2020

Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism. (Shao J, Huang CH, Shao B, Qin L, Xu D, Li F, Qu N, Xie LN, Kalyanaraman B, Zhu BZ) Environ Sci Technol 2020 May 19;54(10):6244-6253 PMID: 32323976 SCOPUS ID: 2-s2.0-85084941154 04/24/2020 13 Citations

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. (Zhang Q, Cheng G, Pan J, Zielonka J, Xiong D, Myers CR, Feng L, Shin SS, Kim YH, Bui D, Hu M, Bennett B, Schmainda K, Wang Y, Kalyanaraman B, You M) Cell Commun Signal 2020 Apr 07;18(1):58 PMID: 32264893 PMCID: PMC7140380 SCOPUS ID: 2-s2.0-85083071315 04/09/2020 18 Citations

Corrigendum to "An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids" [Free Radic. Biol. Med. 146 (2020) 150-159/FRBM_2019_405]. (Xu D, Huang CH, Qin L, Xie LN, Mao L, Shao J, Kalyanaraman B, Zhu BZ) Free Radic Biol Med 2020 May 20;152:869 PMID: 32253053 SCOPUS ID: 2-s2.0-85083056072 04/08/2020

Tracking isotopically labeled oxidants using boronate-based redox probes. (Rios N, Radi R, Kalyanaraman B, Zielonka J) J Biol Chem 2020 May 08;295(19):6665-6676 PMID: 32217693 PMCID: PMC7212653 SCOPUS ID: 2-s2.0-85084721806 03/29/2020 17 Citations

Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? (Kalyanaraman B) Redox Biology January 2020;29 SCOPUS ID: 2-s2.0-85075628069 01/01/2020 202 Citations

Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses. (Cheng G, Pan J, Podsiadly R, Zielonka J, Garces AM, Dias Duarte Machado LG, Bennett B, McAllister D, Dwinell MB, You M, Kalyanaraman B) Free Radic Biol Med 2020 Feb 01;147:167-174 PMID: 31874251 PMCID: PMC6948008 SCOPUS ID: 2-s2.0-85076857582 12/25/2019 16 Citations

Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? (Kalyanaraman B) Redox Biol 2020 Jan;29:101394 PMID: 31790851 PMCID: PMC6909145 SCOPUS ID: 2-s2.0-85075628069 12/04/2019 202 Citations

Molecular mechanism for the activation of the anti-tuberculosis drug isoniazid by Mn(III): First detection and unequivocal identification of the critical N-centered isoniazidyl radical and its exact location. (Qin L, Huang CH, Xu D, Xie LN, Shao J, Mao L, Kalyanaraman B, Zhu BZ) Free Radic Biol Med 2019 Nov 01;143:232-239 PMID: 31319159 SCOPUS ID: 2-s2.0-85070677474 07/19/2019 11 Citations

An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids. (Zhu BZ, Xu D, Qin L, Huang CH, Xie LN, Mao L, Shao J, Kalyanaraman B) Free Radic Biol Med 2020 Jan;146:150-159 PMID: 31302229 SCOPUS ID: 2-s2.0-85075485756 07/16/2019 10 Citations

The p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 Jun 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019 26 Citations

Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators. (Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B) Oncotarget 2019 May 28;10(37):3518-3532 PMID: 31191823 PMCID: PMC6544408 SCOPUS ID: 2-s2.0-85089087803 06/14/2019 14 Citations

Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals. (Besson E, Gastaldi S, Bloch E, Zielonka J, Zielonka M, Kalyanaraman B, Aslan S, Karoui H, Rockenbauer A, Ouari O, Hardy M) Analyst 2019 Jul 21;144(14):4194-4203 PMID: 31180410 SCOPUS ID: 2-s2.0-85068588717 06/11/2019 18 Citations

High-Throughput Screening of NOX Inhibitors. (Zielonka J, Zielonka M, Cheng G, Hardy M, Kalyanaraman B) Methods Mol Biol 2019;1982:429-446 PMID: 31172487 PMCID: PMC6953630 SCOPUS ID: 2-s2.0-85067079084 06/07/2019 10 Citations

HPLC-Based Monitoring of Oxidation of Hydroethidine for the Detection of NADPH Oxidase-Derived Superoxide Radical Anion. (Zielonka J, Zielonka M, Kalyanaraman B) Methods Mol Biol 2019;1982:243-258 PMID: 31172476 PMCID: PMC6953631 SCOPUS ID: 2-s2.0-85066970086 06/07/2019 7 Citations

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. (Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, Zielonka M, Myers CR, Zielonka J, Weh K, Chang AC, Chen G, Kresty L, Kalyanaraman B, You M) Nat Commun 2019 May 17;10(1):2205 PMID: 31101821 PMCID: PMC6525201 SCOPUS ID: 2-s2.0-85065824371 05/19/2019 149 Citations

Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens. (Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ) Carcinogenesis 2019 Sep 18;40(9):1153-1163 PMID: 30870561 SCOPUS ID: 2-s2.0-85077104103 03/15/2019 15 Citations

Introduction to the Second Adriatic Symposium on Biophysical Approaches in Biomedical Studies (Berliner L, Raguz M, Kalyanaraman B, Sarna T) Cell Biochemistry and Biophysics 15 March 2019;77(1) PMID: 30806962 SCOPUS ID: 2-s2.0-85062443442 03/15/2019

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 SCOPUS ID: 2-s2.0-85063413951 11/15/2018 41 Citations

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. (Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD) J Biomed Mater Res A 2018 Nov;106(11):2881-2890 PMID: 30369055 PMCID: PMC6366942 SCOPUS ID: 2-s2.0-85055703769 10/29/2018 19 Citations

An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions. (Xie LN, Shao J, Huang CH, Li F, Xu D, Kalyanaraman B, Zhu BZ) Free Radic Biol Med 2019 Jan;130:1-7 PMID: 30352302 SCOPUS ID: 2-s2.0-85055679458 10/24/2018 11 Citations

Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies. (Kalyanaraman B, Cheng G, Zielonka J, Bennett B) Cell Biochem Biophys 2019 Mar;77(1):89-98 PMID: 30259334 PMCID: PMC6430651 SCOPUS ID: 2-s2.0-85054023520 09/28/2018 11 Citations

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB) J Biol Chem 2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 SCOPUS ID: 2-s2.0-85054023214 08/09/2018 97 Citations

Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future. (Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B) J Biol Chem 2018 Jun 29;293(26):10363-10380 PMID: 29739855 PMCID: PMC6028982 SCOPUS ID: 2-s2.0-85049623107 05/10/2018 76 Citations

Kindlin-3 negatively regulates the release of neutrophil extracellular traps. (Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ) J Leukoc Biol 2018 Sep;104(3):597-602 PMID: 29656482 PMCID: PMC6113072 SCOPUS ID: 2-s2.0-85045414281 04/16/2018 12 Citations

Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2018 Nov 20;128:3-22 PMID: 29567392 PMCID: PMC6146080 SCOPUS ID: 2-s2.0-85054207129 03/24/2018 57 Citations

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Jun;16:426-427 PMID: 29548725 PMCID: PMC5952812 SCOPUS ID: 2-s2.0-85043469209 03/20/2018 6 Citations

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J) Redox Biol 2018 May;15:347-362 PMID: 29306792 PMCID: PMC5756055 SCOPUS ID: 2-s2.0-85039930921 01/08/2018 157 Citations

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2018 Apr;14:694-696 PMID: 29107648 PMCID: PMC5975209 SCOPUS ID: 2-s2.0-85032289195 11/07/2017 10 Citations

Unusual Double Beckmann Fragmentation Reaction under Physiological Conditions. (Xie LN, Huang CH, Xu D, Li F, Zhu JG, Shen C, Shao B, Gao HY, Kalyanaraman B, Zhu BZ) J Org Chem 2017 Dec 15;82(24):13084-13092 PMID: 29096055 SCOPUS ID: 2-s2.0-85038437372 11/03/2017 8 Citations

Xth EPR Workshop on Applications of EPR in Biology and Medicine. (Sarna T, Kalyanaraman B, Berliner L) Cell Biochem Biophys 2017 Dec;75(3-4):257-258 PMID: 29071513 PMCID: PMC5691121 SCOPUS ID: 2-s2.0-85032214099 10/27/2017

Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. (Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O) Antioxid Redox Signal 2018 May 20;28(15):1416-1432 PMID: 29037049 PMCID: PMC5910052 SCOPUS ID: 2-s2.0-85045516114 10/19/2017 66 Citations

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 Apr;14:316-327 PMID: 29017115 PMCID: PMC5633086 SCOPUS ID: 2-s2.0-85030681499 10/11/2017 165 Citations

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. (Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B) Cell Biochem Biophys 2017 Dec;75(3-4):335-349 PMID: 28660426 PMCID: PMC5693611 SCOPUS ID: 2-s2.0-85025160609 07/01/2017 22 Citations

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. (Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B) Chem Rev 2017 Aug 09;117(15):10043-10120 PMID: 28654243 PMCID: PMC5611849 SCOPUS ID: 2-s2.0-85027303022 06/28/2017 1031 Citations

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2017 Oct;13:94-162 PMID: 28577489 PMCID: PMC5458069 SCOPUS ID: 2-s2.0-85020032301 06/04/2017 245 Citations

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. (Chandrashekaran V, Seth RK, Dattaroy D, Alhasson F, Ziolenka J, Carson J, Berger FG, Kalyanaraman B, Diehl AM, Chatterjee S) Redox Biol 2017 Oct;13:8-19 PMID: 28551086 PMCID: PMC5447385 SCOPUS ID: 2-s2.0-85019958332 05/30/2017 51 Citations

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism. (Kalyanaraman B) Redox Biol 2017 Aug;12:833-842 PMID: 28448945 PMCID: PMC5406543 SCOPUS ID: 2-s2.0-85018568266 04/28/2017 149 Citations

Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB) Cell Biochem Biophys 2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 SCOPUS ID: 2-s2.0-85018513016 04/22/2017 20 Citations

Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action. (Variar G, Pant T, Singh A, Ravichandran A, Swami S, Kalyanaraman B, Dhanasekaran A) PLoS One 2017;12(4):e0174546 PMID: 28426671 PMCID: PMC5398517 SCOPUS ID: 2-s2.0-85018470963 04/21/2017 1 Citation

Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems? (Kalyanaraman B, Zielonka J) Redox Biol 2017 Aug;12:755-757 PMID: 28415040 PMCID: PMC5397015 SCOPUS ID: 2-s2.0-85017433209 04/18/2017 15 Citations

Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M) Interface Focus 2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 SCOPUS ID: 2-s2.0-85013194895 04/07/2017 23 Citations

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. (Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG) Antioxid Redox Signal 2017 Nov 10;27(14):1048-1066 PMID: 28375739 PMCID: PMC5651937 SCOPUS ID: 2-s2.0-85019331880 04/05/2017 94 Citations

Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates. (Gao HY, Mao L, Li F, Xie LN, Huang CH, Shao J, Shao B, Kalyanaraman B, Zhu BZ) Environ Sci Technol 2017 Mar 07;51(5):2934-2943 PMID: 28128926 PMCID: PMC5806603 SCOPUS ID: 2-s2.0-85020436109 01/28/2017 31 Citations

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival. (Zhao B, Qiang L, Joseph J, Kalyanaraman B, Viollet B, He YY) Genes Dis 2016 Mar;3(1):82-87 PMID: 28066797 PMCID: PMC5215801 SCOPUS ID: 2-s2.0-84978154338 01/10/2017 51 Citations

Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review (Hogg N, Zielonka J, Kalyanaraman B) Nitric Oxide: Biology and Pathobiology: Third Edition 1 January 2017:23-44 SCOPUS ID: 2-s2.0-85032168005 01/01/2017 13 Citations

A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity. (Kalyanaraman B, Hardy M, Zielonka J) Curr Pharmacol Rep 2016 Aug;2(4):193-201 PMID: 27774407 PMCID: PMC5070669 SCOPUS ID: 2-s2.0-85012255350 10/25/2016 29 Citations

Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy. (Brenza TM, Ghaisas S, Ramirez JEV, Harischandra D, Anantharam V, Kalyanaraman B, Kanthasamy AG, Narasimhan B) Nanomedicine 2017 Apr;13(3):809-820 PMID: 27771430 PMCID: PMC5392427 SCOPUS ID: 2-s2.0-85013270036 10/25/2016 76 Citations

On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products. (Zielonka J, Podsiadły R, Zielonka M, Hardy M, Kalyanaraman B) Free Radic Biol Med 2016 Oct;99:32-42 PMID: 27458121 PMCID: PMC5107150 SCOPUS ID: 2-s2.0-84979887634 10/23/2016 42 Citations

Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling. (Kalyanaraman B, Hardy M, Podsiadly R, Cheng G, Zielonka J) Arch Biochem Biophys 2017 Mar 01;617:38-47 PMID: 27590268 PMCID: PMC5318280 SCOPUS ID: 2-s2.0-84995422269 09/04/2016 101 Citations

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. (Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B) Cancer Res 2016 Jul 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 SCOPUS ID: 2-s2.0-84977588183 05/25/2016 153 Citations

Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies. (Dębski D, Smulik R, Zielonka J, Michałowski B, Jakubowska M, Dębowska K, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) Free Radic Biol Med 2016 Jun;95:323-32 PMID: 27021961 PMCID: PMC5697983 SCOPUS ID: 2-s2.0-84963657120 03/30/2016 107 Citations

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. (Ghosh A, Langley MR, Harischandra DS, Neal ML, Jin H, Anantharam V, Joseph J, Brenza T, Narasimhan B, Kanthasamy A, Kalyanaraman B, Kanthasamy AG) J Neuroimmune Pharmacol 2016 Jun;11(2):259-78 PMID: 26838361 PMCID: PMC4995106 SCOPUS ID: 2-s2.0-84964829444 02/04/2016 82 Citations

Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. (Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadły R, Sikora A, Lambeth JD, Kalyanaraman B) J Biol Chem 2016 Mar 25;291(13):7029-44 PMID: 26839313 PMCID: PMC4807286 SCOPUS ID: 2-s2.0-84964907042 02/04/2016 56 Citations

The Dose-Response Relationship of bacillus Calmette-Guérin and Urothelial Carcinoma Cell Biology. (Shah G, Zhang G, Chen F, Cao Y, Kalyanaraman B, See WA) J Urol 2016 Jun;195(6):1903-10 PMID: 26694905 PMCID: PMC5796534 SCOPUS ID: 2-s2.0-84964576084 12/24/2015 10 Citations

Pancreatic Cancer Cell Migration and Metastasis Is Regulated by Chemokine-Biased Agonism and Bioenergetic Signaling. (Roy I, McAllister DM, Gorse E, Dixon K, Piper CT, Zimmerman NP, Getschman AE, Tsai S, Engle DD, Evans DB, Volkman BF, Kalyanaraman B, Dwinell MB) Cancer Res 2015 Sep 01;75(17):3529-42 PMID: 26330165 PMCID: PMC4560104 SCOPUS ID: 2-s2.0-84942898695 09/04/2015 52 Citations

Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes--Limitations, progress, and perspectives. (Debowska K, Debski D, Hardy M, Jakubowska M, Kalyanaraman B, Marcinek A, Michalski R, Michalowski B, Ouari O, Sikora A, Smulik R, Zielonka J) Pharmacol Rep 2015 Aug;67(4):756-64 PMID: 26321278 PMCID: PMC5793900 SCOPUS ID: 2-s2.0-84940462191 09/01/2015 47 Citations

Intrinsic Chemiluminescence Generation during Advanced Oxidation of Persistent Halogenated Aromatic Carcinogens. (Mao L, Liu YX, Huang CH, Gao HY, Kalyanaraman B, Zhu BZ) Environ Sci Technol 2015 Jul 07;49(13):7940-7 PMID: 26009932 SCOPUS ID: 2-s2.0-84936972564 05/27/2015 33 Citations

Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism. (Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B) Cancer Lett 2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 SCOPUS ID: 2-s2.0-84930823628 05/26/2015 61 Citations

NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment. (Das S, Alhasson F, Dattaroy D, Pourhoseini S, Seth RK, Nagarkatti M, Nagarkatti PS, Michelotti GA, Diehl AM, Kalyanaraman B, Chatterjee S) Am J Pathol 2015 Jul;185(7):1944-57 PMID: 25989356 PMCID: PMC4483465 SCOPUS ID: 2-s2.0-84931296724 05/20/2015 36 Citations

Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro. (Zhang Q, Pan J, Lubet RA, Komas SM, Kalyanaraman B, Wang Y, You M) Cancer Prev Res (Phila) 2015 Apr;8(4):318-26 PMID: 25644152 PMCID: PMC6004825 SCOPUS ID: 2-s2.0-84927674589 02/04/2015 23 Citations

Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid. (Zielonka J, Sikora A, Adamus J, Kalyanaraman B) Methods Mol Biol 2015;1264:171-81 PMID: 25631013 PMCID: PMC4451192 SCOPUS ID: 2-s2.0-84958629324 01/30/2015 28 Citations

Even free radicals should follow some rules: a guide to free radical research terminology and methodology. (Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ 2nd, Vina J, Davies KJ) Free Radic Biol Med 2015 Jan;78:233-5 PMID: 25462642 SCOPUS ID: 2-s2.0-84919701110 12/03/2014 237 Citations

Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications. (Smulik R, Dębski D, Zielonka J, Michałowski B, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) J Biol Chem 2014 Dec 19;289(51):35570-81 PMID: 25378389 PMCID: PMC4271240 SCOPUS ID: 2-s2.0-84919475251 11/08/2014 64 Citations

A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. (Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2014 Nov 07;583:159-64 PMID: 25263790 PMCID: PMC4253647 SCOPUS ID: 2-s2.0-84907997127 09/30/2014 41 Citations

Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. (Pan J, Zhang Q, Liu Q, Komas SM, Kalyanaraman B, Lubet RA, Wang Y, You M) Cancer Prev Res (Phila) 2014 Nov;7(11):1149-59 PMID: 25245764 PMCID: PMC6010030 SCOPUS ID: 2-s2.0-84910118566 09/24/2014 35 Citations

Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. (Michalski R, Zielonka J, Gapys E, Marcinek A, Joseph J, Kalyanaraman B) J Biol Chem 2014 Aug 08;289(32):22536-53 PMID: 24928516 PMCID: PMC4139259 SCOPUS ID: 2-s2.0-84905844117 06/15/2014 61 Citations

H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology. (Shah G, Zielonka J, Chen F, Zhang G, Cao Y, Kalyanaraman B, See W) J Urol 2014 Oct;192(4):1238-48 PMID: 24928267 PMCID: PMC5798233 SCOPUS ID: 2-s2.0-84921941445 06/15/2014 19 Citations

Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake. (Hardy M, Poulhés F, Rizzato E, Rockenbauer A, Banaszak K, Karoui H, Lopez M, Zielonka J, Vasquez-Vivar J, Sethumadhavan S, Kalyanaraman B, Tordo P, Ouari O) Chem Res Toxicol 2014 Jul 21;27(7):1155-65 PMID: 24890552 PMCID: PMC5452977 SCOPUS ID: 2-s2.0-84904659978 06/04/2014 25 Citations

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. (Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B) Br J Cancer 2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 SCOPUS ID: 2-s2.0-84904114424 05/29/2014 68 Citations

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases. (Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, Michalski R, O'Brien WJ, Lambeth JD, Kalyanaraman B) J Biol Chem 2014 Jun 06;289(23):16176-89 PMID: 24764302 PMCID: PMC4047388 SCOPUS ID: 2-s2.0-84902206908 04/26/2014 63 Citations

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. (Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP) Free Radic Biol Med 2014 Aug;73:51-9 PMID: 24746617 PMCID: PMC4111989 SCOPUS ID: 2-s2.0-84901763503 04/22/2014 72 Citations

Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function. (Mouradian M, Kikawa KD, Dranka BP, Komas SM, Kalyanaraman B, Pardini RS) Mol Carcinog 2015 Sep;54(9):810-20 PMID: 24729481 SCOPUS ID: 2-s2.0-84938965067 04/15/2014 42 Citations

Erratum: Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: Detection, oxidative damage and catalytic removal by Mn-porphyrins (Archives of Biochemistry and Biophysics (2013) 529 (45-54)) (Valez V, Cassina A, Batinic-Haberle I, Kalyanaraman B, Ferrer-Sueta G, Radi R) Archives of Biochemistry and Biophysics 1 April 2014;547:44 SCOPUS ID: 2-s2.0-84898058439 04/01/2014

Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses. (Koto T, Michalski R, Zielonka J, Joseph J, Kalyanaraman B) Free Radic Res 2014 Apr;48(4):478-86 PMID: 24460755 PMCID: PMC4780754 SCOPUS ID: 2-s2.0-84895739300 01/28/2014 6 Citations

On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment. (Michalski R, Michalowski B, Sikora A, Zielonka J, Kalyanaraman B) Free Radic Biol Med 2014 Feb;67:278-84 PMID: 24200598 PMCID: PMC4275029 SCOPUS ID: 2-s2.0-84889578332 11/10/2013 49 Citations

Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction. (Srinivasan S, Spear J, Chandran K, Joseph J, Kalyanaraman B, Avadhani NG) PLoS One 2013;8(10):e77129 PMID: 24130844 PMCID: PMC3795003 SCOPUS ID: 2-s2.0-84885398887 10/17/2013 51 Citations

On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. (Zielonka J, Lambeth JD, Kalyanaraman B) Free Radic Biol Med 2013 Dec;65:1310-1314 PMID: 24080119 PMCID: PMC4274999 SCOPUS ID: 2-s2.0-84886048542 10/02/2013 106 Citations

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. (Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG) Biochim Biophys Acta 2014 Aug;1842(8):1282-94 PMID: 24060637 PMCID: PMC3961561 SCOPUS ID: 2-s2.0-84903301367 09/26/2013 263 Citations

iNOS expression and NO production contribute to the direct effects of BCG on urothelial carcinoma cell biology. (Shah G, Zhang G, Chen F, Cao Y, Kalyanaraman B, See WA) Urol Oncol 2014 Jan;32(1):45.e1-9 PMID: 24054867 PMCID: PMC5798243 SCOPUS ID: 2-s2.0-84890805014 09/24/2013 18 Citations

Loss of bacillus Calmette-Guérin viability adversely affects the direct response of urothelial carcinoma cells to bacillus Calmette-Guérin exposure. (Shah G, Zhang G, Chen F, Cao Y, Kalyanaraman B, See W) J Urol 2014 Mar;191(3):823-9 PMID: 24035882 PMCID: PMC5798236 SCOPUS ID: 2-s2.0-84893823729 09/17/2013 6 Citations

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. (Kalyanaraman B) Redox Biol 2013 Feb 08;1(1):244-57 PMID: 24024158 PMCID: PMC3757692 SCOPUS ID: 2-s2.0-84878776025 09/12/2013 402 Citations

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. (Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA) PLoS One 2013;8(8):e70575 PMID: 23940596 PMCID: PMC3734284 SCOPUS ID: 2-s2.0-84881115392 08/14/2013 57 Citations

Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma. (Dilip A, Cheng G, Joseph J, Kunnimalaiyaan S, Kalyanaraman B, Kunnimalaiyaan M, Gamblin TC) Anticancer Drugs 2013 Oct;24(9):881-8 PMID: 23872912 PMCID: PMC4028966 SCOPUS ID: 2-s2.0-84883451405 07/23/2013 27 Citations

Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes. (Zielonka J, Joseph J, Sikora A, Kalyanaraman B) Methods Enzymol 2013;526:145-57 PMID: 23791099 PMCID: PMC6941666 SCOPUS ID: 2-s2.0-84879763530 06/26/2013 22 Citations

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 SCOPUS ID: 2-s2.0-84878817212 06/15/2013 106 Citations

The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. (Huang CH, Shan GQ, Mao L, Kalyanaraman B, Qin H, Ren FR, Zhu BZ) Chem Commun (Camb) 2013 Jul 21;49(57):6436-8 PMID: 23752136 SCOPUS ID: 2-s2.0-84880858809 06/12/2013 33 Citations

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. (Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2013 Aug 09;549:57-62 PMID: 23721786 PMCID: PMC3729885 SCOPUS ID: 2-s2.0-84880750830 06/01/2013 31 Citations

An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 SCOPUS ID: 2-s2.0-84878725519 05/30/2013 76 Citations

Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. (Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ) Free Radic Biol Med 2013 Oct;63:459-66 PMID: 23680403 PMCID: PMC5806606 SCOPUS ID: 2-s2.0-84879800871 05/18/2013 23 Citations

HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection. (Kalyanaraman B, Dranka BP, Hardy M, Michalski R, Zielonka J) Biochim Biophys Acta 2014 Feb;1840(2):739-44 PMID: 23668959 PMCID: PMC3858408 SCOPUS ID: 2-s2.0-84890117297 05/15/2013 92 Citations

Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. (Sikora A, Zielonka J, Adamus J, Debski D, Dybala-Defratyka A, Michalowski B, Joseph J, Hartley RC, Murphy MP, Kalyanaraman B) Chem Res Toxicol 2013 Jun 17;26(6):856-67 PMID: 23611338 PMCID: PMC3700382 SCOPUS ID: 2-s2.0-84879154470 04/25/2013 42 Citations

Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (Myers JM, Cheng Q, Antholine WE, Kalyanaraman B, Filipovska A, Arnér ES, Myers CR) Free Radic Biol Med 2013 Jul;60:183-94 PMID: 23485585 PMCID: PMC3654041 SCOPUS ID: 2-s2.0-84875404357 03/15/2013 21 Citations

Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. (Shao J, Huang CH, Kalyanaraman B, Zhu BZ) Free Radic Biol Med 2013 Jul;60:177-82 PMID: 23376470 PMCID: PMC4476646 SCOPUS ID: 2-s2.0-84875391149 02/05/2013 43 Citations

Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. (Valez V, Cassina A, Batinic-Haberle I, Kalyanaraman B, Ferrer-Sueta G, Radi R) Arch Biochem Biophys 2013 Jan 01;529(1):45-54 PMID: 23142682 PMCID: PMC3534903 SCOPUS ID: 2-s2.0-84871774662 11/13/2012 34 Citations

Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. (Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG) J Neuroinflammation 2012 Oct 23;9:241 PMID: 23092448 PMCID: PMC3488558 SCOPUS ID: 2-s2.0-84867670576 10/25/2012 93 Citations

Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide. (Michalski R, Zielonka J, Hardy M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2013 Jan;54:135-47 PMID: 23051008 PMCID: PMC3711142 SCOPUS ID: 2-s2.0-84871920872 10/12/2012 42 Citations

Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells. (Cunniff B, Benson K, Stumpff J, Newick K, Held P, Taatjes D, Joseph J, Kalyanaraman B, Heintz NH) J Cell Physiol 2013 Apr;228(4):835-45 PMID: 23018647 PMCID: PMC3928986 SCOPUS ID: 2-s2.0-84871680714 09/29/2012 39 Citations

Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. (Zhu BZ, Mao L, Huang CH, Qin H, Fan RM, Kalyanaraman B, Zhu JG) Proc Natl Acad Sci U S A 2012 Oct 02;109(40):16046-51 PMID: 22988069 PMCID: PMC3479549 SCOPUS ID: 2-s2.0-84867036556 09/19/2012 95 Citations

Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. (Zielonka J, Sikora A, Hardy M, Joseph J, Dranka BP, Kalyanaraman B) Chem Res Toxicol 2012 Sep 17;25(9):1793-9 PMID: 22731669 PMCID: PMC3501381 SCOPUS ID: 2-s2.0-84866386085 06/27/2012 198 Citations

Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. (Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B) J Neurochem 2012 Sep;122(5):941-51 PMID: 22708893 PMCID: PMC3423581 SCOPUS ID: 2-s2.0-84865321842 06/20/2012 51 Citations

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants. (Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Sep 01;53(5):1123-38 PMID: 22683818 PMCID: PMC3432152 SCOPUS ID: 2-s2.0-84864956266 06/12/2012 114 Citations

Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: computer simulation studies in model tyrosine-cysteine peptides in solution. (Petruk AA, Bartesaghi S, Trujillo M, Estrin DA, Murgida D, Kalyanaraman B, Marti MA, Radi R) Arch Biochem Biophys 2012 Sep 01;525(1):82-91 PMID: 22640642 PMCID: PMC3414218 SCOPUS ID: 2-s2.0-84864288909 05/30/2012 30 Citations

Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. (Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P) J Histochem Cytochem 2012 Jul;60(7):521-9 PMID: 22511597 PMCID: PMC3460350 SCOPUS ID: 2-s2.0-84865847205 04/19/2012 97 Citations

Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 SCOPUS ID: 2-s2.0-84861158967 03/21/2012 200 Citations

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. (Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG) J Biol Chem 2012 May 04;287(19):15284-97 PMID: 22396533 PMCID: PMC3346148 SCOPUS ID: 2-s2.0-84860869284 03/08/2012 28 Citations

Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. (Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, Mutlu GM, De Vizcaya-Ruiz A, Budinger GR) Sci Rep 2012;2:275 PMID: 22355787 PMCID: PMC3281276 SCOPUS ID: 2-s2.0-84859771300 02/23/2012 86 Citations

Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. (Zielonka J, Zielonka M, Sikora A, Adamus J, Joseph J, Hardy M, Ouari O, Dranka BP, Kalyanaraman B) J Biol Chem 2012 Jan 27;287(5):2984-95 PMID: 22139901 PMCID: PMC3270955 SCOPUS ID: 2-s2.0-84856248241 12/06/2011 155 Citations

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. (Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Jan 15;52(2):497-506 PMID: 22120494 PMCID: PMC3253235 SCOPUS ID: 2-s2.0-84855448154 11/29/2011 177 Citations

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. (Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ 2nd, Ischiropoulos H) Free Radic Biol Med 2012 Jan 01;52(1):1-6 PMID: 22027063 PMCID: PMC3911769 SCOPUS ID: 2-s2.0-84655163961 10/27/2011 1365 Citations

Mitochondrial complex III ROS regulate adipocyte differentiation. (Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS) Cell Metab 2011 Oct 05;14(4):537-44 PMID: 21982713 PMCID: PMC3190168 SCOPUS ID: 2-s2.0-80053904684 10/11/2011 526 Citations

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species. (Kalyanaraman B) Biochem Soc Trans 2011 Oct;39(5):1221-5 PMID: 21936793 SCOPUS ID: 2-s2.0-80053371451 09/23/2011 63 Citations

Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice. (Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B, Beckman JS) Neurobiol Dis 2012 Jan;45(1):137-44 PMID: 21820513 PMCID: PMC3710723 SCOPUS ID: 2-s2.0-81955168003 08/09/2011 44 Citations

Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 SCOPUS ID: 2-s2.0-80054116454 07/30/2011 26 Citations

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. (Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM) Hepatology 2011 Jul;54(1):153-63 PMID: 21520201 PMCID: PMC3125473 SCOPUS ID: 2-s2.0-79959538979 04/27/2011 103 Citations

Unraveling the biological roles of reactive oxygen species. (Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC) Cell Metab 2011 Apr 06;13(4):361-366 PMID: 21459321 PMCID: PMC4445605 SCOPUS ID: 2-s2.0-79953762174 04/05/2011 644 Citations

Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway. (Sikora A, Zielonka J, Lopez M, Dybala-Defratyka A, Joseph J, Marcinek A, Kalyanaraman B) Chem Res Toxicol 2011 May 16;24(5):687-97 PMID: 21434648 PMCID: PMC3743543 SCOPUS ID: 2-s2.0-84962440502 03/26/2011 86 Citations

Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte. (Kumar SN, Konorev EA, Aggarwal D, Kalyanaraman B) J Proteomics 2011 May 01;74(5):683-97 PMID: 21338723 PMCID: PMC3298037 SCOPUS ID: 2-s2.0-79953309047 02/23/2011 27 Citations

Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. (Shchepin R, Möller MN, Kim HY, Hatch DM, Bartesaghi S, Kalyanaraman B, Radi R, Porter NA) J Am Chem Soc 2010 Dec 15;132(49):17490-500 PMID: 21090613 PMCID: PMC3677824 SCOPUS ID: 2-s2.0-78650142806 11/26/2010 31 Citations

Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism. (Zhu BZ, Zhu JG, Mao L, Kalyanaraman B, Shan GQ) Proc Natl Acad Sci U S A 2010 Nov 30;107(48):20686-90 PMID: 21076034 PMCID: PMC2996439 SCOPUS ID: 2-s2.0-78650583096 11/16/2010 51 Citations

Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. (Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, Frei B) Chem Res Toxicol 2011 Jan 14;24(1):30-4 PMID: 21047085 SCOPUS ID: 2-s2.0-78651469381 11/05/2010 92 Citations

Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate-stimulated peroxidase and thiol oxidase activities: pulse EPR and NMR studies. (Chandran K, McCracken J, Peterson FC, Antholine WE, Volkman BF, Kalyanaraman B) Biochemistry 2010 Dec 21;49(50):10616-22 PMID: 21038859 PMCID: PMC3501376 SCOPUS ID: 2-s2.0-78650389551 11/03/2010 13 Citations

Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. (Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B) Free Radic Biol Med 2010 Dec 01;49(11):1674-84 PMID: 20828611 PMCID: PMC4020411 SCOPUS ID: 2-s2.0-78049357951 09/11/2010 154 Citations

Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. (Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar V) Biochem J 2010 Nov 15;432(1):9-19 PMID: 20825366 PMCID: PMC2973231 SCOPUS ID: 2-s2.0-78649755150 09/10/2010 192 Citations

The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. (Rao VA, Klein SR, Bonar SJ, Zielonka J, Mizuno N, Dickey JS, Keller PW, Joseph J, Kalyanaraman B, Shacter E) J Biol Chem 2010 Nov 05;285(45):34447-59 PMID: 20805228 PMCID: PMC2966059 SCOPUS ID: 2-s2.0-78049398265 09/02/2010 122 Citations

Reply to Jourd'heuil: Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) Journal of Biological Chemistry 27 August 2010;285(35) SCOPUS ID: 2-s2.0-77956241159 08/27/2010 14 Citations

Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. (Dasgupta J, Kar S, Liu R, Joseph J, Kalyanaraman B, Remington SJ, Chen C, Melendez JA) J Cell Physiol 2010 Oct;225(1):52-62 PMID: 20648623 PMCID: PMC2913426 SCOPUS ID: 2-s2.0-77956555183 07/22/2010 61 Citations

NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. (Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NR) Antioxid Redox Signal 2011 Feb 15;14(4):533-42 PMID: 20618070 PMCID: PMC3038125 SCOPUS ID: 2-s2.0-79251546780 07/14/2010 69 Citations

The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. (Cheng Q, Antholine WE, Myers JM, Kalyanaraman B, Arnér ES, Myers CR) J Biol Chem 2010 Jul 09;285(28):21708-23 PMID: 20457604 PMCID: PMC2898413 SCOPUS ID: 2-s2.0-77954355103 05/12/2010 56 Citations

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. (Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS) Proc Natl Acad Sci U S A 2010 May 11;107(19):8788-93 PMID: 20421486 PMCID: PMC2889315 SCOPUS ID: 2-s2.0-77952737658 04/28/2010 1333 Citations

Role of mitochondrial reactive oxygen species in osteoclast differentiation. (Srinivasan S, Koenigstein A, Joseph J, Sun L, Kalyanaraman B, Zaidi M, Avadhani NG) Ann N Y Acad Sci 2010 Mar;1192(1):245-52 PMID: 20392243 PMCID: PMC2856121 SCOPUS ID: 2-s2.0-77950686292 04/16/2010 101 Citations

Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe. (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) J Biol Chem 2010 May 07;285(19):14210-6 PMID: 20194496 PMCID: PMC2863194 SCOPUS ID: 2-s2.0-77951988104 03/03/2010 179 Citations

Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. (Bartesaghi S, Wenzel J, Trujillo M, López M, Joseph J, Kalyanaraman B, Radi R) Chem Res Toxicol 2010 Apr 19;23(4):821-35 PMID: 20170094 PMCID: PMC3506709 SCOPUS ID: 2-s2.0-77951216182 02/23/2010 66 Citations

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2010 Apr 15;48(8):983-1001 PMID: 20116425 PMCID: PMC3587154 SCOPUS ID: 2-s2.0-77950515980 02/02/2010 408 Citations

Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. (Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, Kalyanaraman B, Landar A, Darley-Usmar VM) Biochem J 2010 Jan 27;426(1):31-41 PMID: 19916962 PMCID: PMC3079364 SCOPUS ID: 2-s2.0-76549096602 11/18/2009 51 Citations

A (99m)Tc-labeled triphenylphosphonium derivative for the early detection of breast tumors. (Li Z, Lopez M, Hardy M, McAllister DM, Kalyanaraman B, Zhao M) Cancer Biother Radiopharm 2009 Oct;24(5):579-87 PMID: 19877888 PMCID: PMC2883499 SCOPUS ID: 2-s2.0-70449135470 11/03/2009 21 Citations

Physiological fluctuation of (99m)Tc-sestamibi uptake in normal mammary glands: a systematic investigation in female rats. (Larson M, Larson M, Li Z, Larson M, Li Z, Hall CL, Jensen E, McAllister DM, Kalyanaraman B, Zhao M) Acta Radiol 2009 Nov;50(9):975-8 PMID: 19863405 SCOPUS ID: 2-s2.0-70449122863 10/30/2009 3 Citations

Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease. (Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2010 Feb 01;48(3):377-83 PMID: 19857570 PMCID: PMC4485429 SCOPUS ID: 2-s2.0-73449099224 10/28/2009 40 Citations

Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. (Subramanian S, Kalyanaraman B, Migrino RQ) Recent Pat Cardiovasc Drug Discov 2010 Jan;5(1):54-65 PMID: 19807685 SCOPUS ID: 2-s2.0-77951143920 10/08/2009 43 Citations

Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. (Sikora A, Zielonka J, Lopez M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2009 Nov 15;47(10):1401-7 PMID: 19686842 PMCID: PMC3375817 SCOPUS ID: 2-s2.0-70350028730 08/19/2009 291 Citations

Decreased S-nitrosation of peptide thiols in the membrane interior. (Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, Kalyanaraman B) Free Radic Biol Med 2009 Oct 01;47(7):962-8 PMID: 19573593 PMCID: PMC2874255 SCOPUS ID: 2-s2.0-69249209615 07/04/2009 15 Citations

Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical. (Zhu BZ, Shan GQ, Huang CH, Kalyanaraman B, Mao L, Du YG) Proc Natl Acad Sci U S A 2009 Jul 14;106(28):11466-71 PMID: 19556549 PMCID: PMC2710671 SCOPUS ID: 2-s2.0-67650886071 06/27/2009 88 Citations

Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production. (Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, Kalyanaraman B, Avadhani NG) Biochem J 2009 May 27;420(3):439-49 PMID: 19338496 PMCID: PMC2735414 SCOPUS ID: 2-s2.0-66949172391 04/03/2009 75 Citations

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. (Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B) Biophys J 2009 Feb 18;96(4):1388-98 PMID: 19217856 PMCID: PMC2717244 SCOPUS ID: 2-s2.0-62649160560 02/17/2009 159 Citations

The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? (Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B) Arch Biochem Biophys 2009 Apr 15;484(2):134-45 PMID: 19056332 PMCID: PMC2874256 SCOPUS ID: 2-s2.0-64749106532 12/06/2008 21 Citations

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. (Zielonka J, Hardy M, Kalyanaraman B) Free Radic Biol Med 2009 Feb 01;46(3):329-38 PMID: 19026738 PMCID: PMC3375818 SCOPUS ID: 2-s2.0-58149168842 11/26/2008 131 Citations

Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes. (Konorev EA, Vanamala S, Kalyanaraman B) Free Radic Biol Med 2008 Dec 15;45(12):1723-8 PMID: 18926904 PMCID: PMC3039518 SCOPUS ID: 2-s2.0-56349128620 10/18/2008 55 Citations

"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2008 Nov 01;45(9):1217-9 PMID: 18789385 PMCID: PMC3595710 SCOPUS ID: 2-s2.0-53449090706 09/16/2008 50 Citations

Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. (Vásquez-Vivar J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM) Free Radic Biol Med 2008 Oct 01;45(7):994-1001 PMID: 18634867 PMCID: PMC2578873 SCOPUS ID: 2-s2.0-51349157985 07/19/2008 14 Citations

Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester. (Bartesaghi S, Peluffo G, Zhang H, Joseph J, Kalyanaraman B, Radi R) Methods Enzymol 2008;441:217-36 PMID: 18554537 SCOPUS ID: 2-s2.0-52049125425 06/17/2008 14 Citations

Influence of intramolecular electron transfer mechanism in biological nitration, nitrosation, and oxidation of redox-sensitive amino acids. (Zhang H, Xu Y, Joseph J, Kalyanaraman B) Methods Enzymol 2008;440:65-94 PMID: 18423211 SCOPUS ID: 2-s2.0-44849111614 04/22/2008 12 Citations

Redox-based regulation of signal transduction: principles, pitfalls, and promises. (Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, Kalyanaraman B, Finkel T, Stamler JS, Rhee SG, van der Vliet A) Free Radic Biol Med 2008 Jul 01;45(1):1-17 PMID: 18423411 PMCID: PMC2453533 SCOPUS ID: 2-s2.0-45049085873 04/22/2008 653 Citations

L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. (Matsunaga T, Kamiya T, Sumi D, Kumagai Y, Kalyanaraman B, Hara A) Free Radic Biol Med 2008 Mar 15;44(6):1191-202 PMID: 18206670 SCOPUS ID: 2-s2.0-39949085604 01/22/2008 53 Citations

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Nat Protoc 2008;3(1):8-21 PMID: 18193017 SCOPUS ID: 2-s2.0-38149142769 01/15/2008 327 Citations

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. (Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, Vasquez-Vivar J, Avadhani NG, Kalyanaraman B) Free Radic Biol Med 2008 Mar 01;44(5):835-46 PMID: 18155177 PMCID: PMC2692199 SCOPUS ID: 2-s2.0-39149083084 12/25/2007 92 Citations

Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. (Zhu BZ, Kalyanaraman B, Jiang GB) Proc Natl Acad Sci U S A 2007 Nov 06;104(45):17575-8 PMID: 17968010 PMCID: PMC2077033 SCOPUS ID: 2-s2.0-36749041417 10/31/2007 153 Citations

Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions. (Romero N, Peluffo G, Bartesaghi S, Zhang H, Joseph J, Kalyanaraman B, Radi R) Chem Res Toxicol 2007 Nov;20(11):1638-48 PMID: 17941688 SCOPUS ID: 2-s2.0-37249045163 10/19/2007 18 Citations

Early detection of doxorubicin cardiomyopathy using two-dimensional strain echocardiography. (Migrino RQ, Aggarwal D, Konorev E, Brahmbhatt T, Bright M, Kalyanaraman B) Ultrasound Med Biol 2008 Feb;34(2):208-14 PMID: 17935867 PMCID: PMC2582214 SCOPUS ID: 2-s2.0-38349141345 10/16/2007 105 Citations

Erratum: Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways (Cancer Research (2007) 67, (7386-7394)) (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Research 15 September 2007;67(18):8973 SCOPUS ID: 2-s2.0-34548717119 09/15/2007 1 Citation

Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Res 2007 Aug 01;67(15):7386-94 PMID: 17671209 SCOPUS ID: 2-s2.0-34547641739 08/03/2007 130 Citations

Iron signaling and oxidant damage. (Kalyanaraman B) Cardiovasc Toxicol 2007;7(2):92-4 PMID: 17652811 SCOPUS ID: 2-s2.0-34548303703 07/27/2007 21 Citations

Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. (Hardy M, Rockenbauer A, Vásquez-Vivar J, Felix C, Lopez M, Srinivasan S, Avadhani N, Tordo P, Kalyanaraman B) Chem Res Toxicol 2007 Jul;20(7):1053-60 PMID: 17559235 PMCID: PMC4455887 SCOPUS ID: 2-s2.0-34547615931 06/15/2007 59 Citations

Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. (Zhu BZ, Zhao HT, Kalyanaraman B, Liu J, Shan GQ, Du YG, Frei B) Proc Natl Acad Sci U S A 2007 Mar 06;104(10):3698-702 PMID: 17360415 PMCID: PMC1820646 SCOPUS ID: 2-s2.0-34247221459 03/16/2007 77 Citations

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 01;42(7):1049-61 PMID: 17349932 PMCID: PMC2692187 SCOPUS ID: 2-s2.0-33847619217 03/14/2007 78 Citations

Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide. (Hardy M, Chalier F, Ouari O, Finet JP, Rockenbauer A, Kalyanaraman B, Tordo P) Chem Commun (Camb) 2007 Mar 14(10):1083-5 PMID: 17325813 SCOPUS ID: 2-s2.0-33847289280 02/28/2007 50 Citations

Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide. (Borthiry GR, Antholine WE, Kalyanaraman B, Myers JM, Myers CR) Free Radic Biol Med 2007 Mar 15;42(6):738-55; discussion 735-7 PMID: 17320757 PMCID: PMC1993546 SCOPUS ID: 2-s2.0-33847017210 02/27/2007 56 Citations

Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. (Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, Andrekopoulos C, Kalyanaraman B, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1323-36 PMID: 17218473 SCOPUS ID: 2-s2.0-34347379767 01/16/2007 105 Citations

Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS? (Xu Y, Kalyanaraman B) Free Radic Res 2007 Jan;41(1):1-7 PMID: 17164173 SCOPUS ID: 2-s2.0-33845451490 12/14/2006 40 Citations

Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. (Zielonka J, Sarna T, Roberts JE, Wishart JF, Kalyanaraman B) Arch Biochem Biophys 2006 Dec 01;456(1):39-47 PMID: 17081495 PMCID: PMC2270254 SCOPUS ID: 2-s2.0-33751438500 11/04/2006 54 Citations

Protein tyrosine nitration in hydrophilic and hydrophobic environments. (Bartesaghi S, Ferrer-Sueta G, Peluffo G, Valez V, Zhang H, Kalyanaraman B, Radi R) Amino Acids 2007;32(4):501-15 PMID: 17077966 SCOPUS ID: 2-s2.0-34249101633 11/02/2006 122 Citations

The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2006 Oct 01;41(7):1050-7 PMID: 16962930 SCOPUS ID: 2-s2.0-33748291680 09/12/2006 50 Citations

Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. (Bartesaghi S, Valez V, Trujillo M, Peluffo G, Romero N, Zhang H, Kalyanaraman B, Radi R) Biochemistry 2006 Jun 06;45(22):6813-25 PMID: 16734418 SCOPUS ID: 2-s2.0-33744959547 06/01/2006 77 Citations

Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. (Whitsett J, Martásek P, Zhao H, Schauer DW, Hatakeyama K, Kalyanaraman B, Vásquez-Vivar J) Free Radic Biol Med 2006 Jun 01;40(11):2056-68 PMID: 16716906 SCOPUS ID: 2-s2.0-33646555780 05/24/2006 35 Citations

Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. (Huh J, Liepins A, Zielonka J, Andrekopoulos C, Kalyanaraman B, Sorokin A) Cancer Res 2006 Apr 01;66(7):3726-36 PMID: 16585199 SCOPUS ID: 2-s2.0-33645734867 04/06/2006 57 Citations

Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. (Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, Kalyanaraman B) Free Radic Biol Med 2006 Mar 15;40(6):1034-44 PMID: 16540399 SCOPUS ID: 2-s2.0-33644852960 03/17/2006 87 Citations

Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases. (Kotamraju S, Kalivendi S, Shang T, Kalyanaraman B) Methods Enzymol 2005;396:526-34 PMID: 16291259 SCOPUS ID: 2-s2.0-27744520419 11/18/2005 7 Citations

Hydrophobic tyrosyl probes for monitoring nitration reactions in membranes. (Zhang H, Joseph J, Kalyanaraman B) Methods Enzymol 2005;396:182-204 PMID: 16291233 SCOPUS ID: 2-s2.0-27744438101 11/18/2005 4 Citations

Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. (Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2005 Oct 15;39(8):1059-74 PMID: 16198233 SCOPUS ID: 2-s2.0-25144483746 10/04/2005 31 Citations

Intramolecular electron transfer between tyrosyl radical and cysteine residue inhibits tyrosine nitration and induces thiyl radical formation in model peptides treated with myeloperoxidase, H2O2, and NO2-: EPR SPIN trapping studies. (Zhang H, Xu Y, Joseph J, Kalyanaraman B) J Biol Chem 2005 Dec 09;280(49):40684-98 PMID: 16176930 SCOPUS ID: 2-s2.0-28844469209 09/24/2005 69 Citations

Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. (Zielonka J, Zhao H, Xu Y, Kalyanaraman B) Free Radic Biol Med 2005 Oct 01;39(7):853-63 PMID: 16140206 SCOPUS ID: 2-s2.0-33644628456 09/06/2005 88 Citations

Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. (Chi L, Ke Y, Luo C, Li B, Gozal D, Kalyanaraman B, Liu R) Stem Cells 2006 Jan;24(1):34-43 PMID: 16099995 PMCID: PMC1828038 SCOPUS ID: 2-s2.0-33645533489 08/16/2005 117 Citations

Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. (Shang T, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2005 Oct 14;280(41):34644-53 PMID: 16085644 SCOPUS ID: 2-s2.0-27144458235 08/09/2005 36 Citations

Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. (Dhanasekaran A, Kotamraju S, Karunakaran C, Kalivendi SV, Thomas S, Joseph J, Kalyanaraman B) Free Radic Biol Med 2005 Sep 01;39(5):567-83 PMID: 16085176 SCOPUS ID: 2-s2.0-23444440170 08/09/2005 180 Citations

Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor. (Sun G, Zhao H, Kalyanaraman B, Dahms NM) Glycobiology 2005 Nov;15(11):1136-49 PMID: 15972892 SCOPUS ID: 2-s2.0-27944458451 06/24/2005 24 Citations

Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid. (Trujillo M, Folkes L, Bartesaghi S, Kalyanaraman B, Wardman P, Radi R) Free Radic Biol Med 2005 Jul 15;39(2):279-88 PMID: 15964519 SCOPUS ID: 2-s2.0-20444456654 06/21/2005 45 Citations

Reductive activation of Cr(Vi) by nitric oxide synthase. (Porter R, Jáchymová M, Martásek P, Kalyanaraman B, Vásquez-Vivar J) Chem Res Toxicol 2005 May;18(5):834-43 PMID: 15892577 SCOPUS ID: 2-s2.0-18944406786 05/17/2005 17 Citations

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. (Zhao H, Joseph J, Fales HM, Sokoloski EA, Levine RL, Vasquez-Vivar J, Kalyanaraman B) Proc Natl Acad Sci U S A 2005 Apr 19;102(16):5727-32 PMID: 15824309 PMCID: PMC556312 SCOPUS ID: 2-s2.0-17644394600 04/13/2005 501 Citations

Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species. (Shi H, Timmins G, Monske M, Burdick A, Kalyanaraman B, Liu Y, Clément JL, Burchiel S, Liu KJ) Arch Biochem Biophys 2005 May 01;437(1):59-68 PMID: 15820217 SCOPUS ID: 2-s2.0-16244368485 04/12/2005 83 Citations

Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. (Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J, Kalyanaraman B) Biochem J 2005 Jul 15;389(Pt 2):527-39 PMID: 15799720 PMCID: PMC1175131 SCOPUS ID: 2-s2.0-22544466964 04/01/2005 173 Citations

Thiol oxidase activity of copper, zinc superoxide dismutase stimulates bicarbonate-dependent peroxidase activity via formation of a carbonate radical. (Karunakaran C, Zhang H, Joseph J, Antholine WE, Kalyanaraman B) Chem Res Toxicol 2005 Mar;18(3):494-500 PMID: 15777089 SCOPUS ID: 2-s2.0-15344350970 03/22/2005 26 Citations

Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? (Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, Vásquez-Vivar J) Free Radic Biol Med 2005 Feb 15;38(4):481-91 PMID: 15649650 SCOPUS ID: 2-s2.0-13844266737 01/15/2005 42 Citations

Mass spectral evidence for carbonate-anion-radical-induced posttranslational modification of tryptophan to kynurenine in human Cu, Zn superoxide dismutase. (Zhang H, Joseph J, Crow J, Kalyanaraman B) Free Radic Biol Med 2004 Dec 15;37(12):2018-26 PMID: 15544920 SCOPUS ID: 2-s2.0-8544240825 11/17/2004 34 Citations

Nitrated lipids: a class of cell-signaling molecules. (Kalyanaraman B) Proc Natl Acad Sci U S A 2004 Aug 10;101(32):11527-8 PMID: 15292510 PMCID: PMC511014 SCOPUS ID: 2-s2.0-4143105890 08/05/2004 67 Citations

Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. (Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A, Joseph J, Kalyanaraman B) J Biol Chem 2004 Sep 03;279(36):37575-87 PMID: 15220329 SCOPUS ID: 2-s2.0-4444315545 06/29/2004 215 Citations

Impact of pulmonary arterial endothelial cells on duroquinone redox status. (Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH) Free Radic Biol Med 2004 Jul 01;37(1):86-103 PMID: 15183197 SCOPUS ID: 2-s2.0-2942562276 06/09/2004 15 Citations

The carbonate radical anion-induced covalent aggregation of human copper, zinc superoxide dismutase, and alpha-synuclein: intermediacy of tryptophan- and tyrosine-derived oxidation products. (Zhang H, Andrekopoulos C, Joseph J, Crow J, Kalyanaraman B) Free Radic Biol Med 2004 Jun 01;36(11):1355-65 PMID: 15135171 SCOPUS ID: 2-s2.0-2342626577 05/12/2004 63 Citations

Direct probing of copper active site and free radical formed during bicarbonate-dependent peroxidase activity of bovine and human copper, zinc-superoxide dismutases. Low-temperature electron paramagnetic resonance and electron nuclear double resonance studies. (Karunakaran C, Zhang H, Crow JP, Antholine WE, Kalyanaraman B) J Biol Chem 2004 Jul 30;279(31):32534-40 PMID: 15123612 SCOPUS ID: 2-s2.0-3543055852 05/05/2004 33 Citations

Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide. (Matsunaga T, Kotamraju S, Kalivendi SV, Dhanasekaran A, Joseph J, Kalyanaraman B) J Biol Chem 2004 Jul 02;279(27):28614-24 PMID: 15102832 SCOPUS ID: 2-s2.0-3142543756 04/23/2004 92 Citations

Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways. (Wang S, Konorev EA, Kotamraju S, Joseph J, Kalivendi S, Kalyanaraman B) J Biol Chem 2004 Jun 11;279(24):25535-43 PMID: 15054096 SCOPUS ID: 2-s2.0-2942616456 04/01/2004 508 Citations

Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis. (Kotamraju S, Kalivendi SV, Konorev E, Chitambar CR, Joseph J, Kalyanaraman B) Methods Enzymol 2004;378:362-82 PMID: 15038980 SCOPUS ID: 2-s2.0-3042828610 03/25/2004 60 Citations

Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function? (Kotamraju S, Tampo Y, Kalivendi SV, Joseph J, Chitambar CR, Kalyanaraman B) Arch Biochem Biophys 2004 Mar 01;423(1):74-80 PMID: 14989268 SCOPUS ID: 2-s2.0-1042302131 03/03/2004 19 Citations

1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. (Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 30;279(18):19099-112 PMID: 14752097 SCOPUS ID: 2-s2.0-2442504779 01/31/2004 57 Citations

Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. (Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 09;279(15):15240-7 PMID: 14742448 SCOPUS ID: 2-s2.0-2442494278 01/27/2004 122 Citations

Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. (Andrekopoulos C, Zhang H, Joseph J, Kalivendi S, Kalyanaraman B) Biochem J 2004 Mar 01;378(Pt 2):435-47 PMID: 14640973 PMCID: PMC1223984 SCOPUS ID: 2-s2.0-1642318678 12/03/2003 36 Citations

Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. (Keszler A, Kalyanaraman B, Hogg N) Free Radic Biol Med 2003 Nov 01;35(9):1149-57 PMID: 14572617 SCOPUS ID: 2-s2.0-0142200248 10/24/2003 62 Citations

Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase. (Duquaine D, Hirsch GA, Chakrabarti A, Han Z, Kehrer C, Brook R, Joseph J, Schott A, Kalyanaraman B, Vasquez-Vivar J, Rajagopalan S) Vasc Med 2003 May;8(2):101-7 PMID: 14518612 SCOPUS ID: 2-s2.0-0141607692 10/02/2003 69 Citations

Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. (Kotamraju S, Tampo Y, Keszler A, Chitambar CR, Joseph J, Haas AL, Kalyanaraman B) Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10653-8 PMID: 12958216 PMCID: PMC196859 SCOPUS ID: 2-s2.0-0141703321 09/06/2003 95 Citations

Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. (Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD) Circ Res 2003 Sep 19;93(6):573-80 PMID: 12919951 SCOPUS ID: 2-s2.0-0141608948 08/16/2003 283 Citations

Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. (Maas M, Wang R, Paddock C, Kotamraju S, Kalyanaraman B, Newman PJ, Newman DK) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2336-44 PMID: 12893640 SCOPUS ID: 2-s2.0-0344616889 08/02/2003 21 Citations

Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID: 12794122 SCOPUS ID: 2-s2.0-0037605943 06/10/2003 70 Citations

Spin traps: in vitro toxicity and stability of radical adducts. (Khan N, Wilmot CM, Rosen GM, Demidenko E, Sun J, Joseph J, O'Hara J, Kalyanaraman B, Swartz HM) Free Radic Biol Med 2003 Jun 01;34(11):1473-81 PMID: 12757857 SCOPUS ID: 2-s2.0-0038030710 05/22/2003 111 Citations

Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. (Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, Vásquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2003 Jun 01;34(11):1359-68 PMID: 12757846 SCOPUS ID: 2-s2.0-0038368985 05/22/2003 670 Citations

NO adducts in mammalian red blood cells: too much or too little? (Rassaf T, Bryan NS, Maloney RE, Specian V, Kelm M, Kalyanaraman B, Rodriguez J, Feelisch M) Nat Med 2003 May;9(5):481-2; author reply 482-3 PMID: 12724738 SCOPUS ID: 2-s2.0-0037902488 05/02/2003 139 Citations

Bicarbonate-dependent peroxidase activity of human Cu,Zn-superoxide dismutase induces covalent aggregation of protein: intermediacy of tryptophan-derived oxidation products. (Zhang H, Andrekopoulos C, Joseph J, Chandran K, Karoui H, Crow JP, Kalyanaraman B) J Biol Chem 2003 Jun 27;278(26):24078-89 PMID: 12686560 SCOPUS ID: 2-s2.0-0037929802 04/11/2003 103 Citations

1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. (Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ) J Neurochem 2003 Apr;85(2):358-67 PMID: 12675912 SCOPUS ID: 2-s2.0-0344406174 04/05/2003 72 Citations

The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. (Vásquez-Vivar J, Kalyanaraman B, Martásek P) Free Radic Res 2003 Feb;37(2):121-7 PMID: 12653200 SCOPUS ID: 2-s2.0-0037305699 03/26/2003 187 Citations

Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. (Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP) Free Radic Biol Med 2003 Apr 01;34(7):892-907 PMID: 12654478 SCOPUS ID: 2-s2.0-0037376429 03/26/2003 17 Citations

1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. (Kalivendi SV, Kotamraju S, Cunningham S, Shang T, Hillard CJ, Kalyanaraman B) Biochem J 2003 Apr 01;371(Pt 1):151-64 PMID: 12523938 PMCID: PMC1223270 SCOPUS ID: 2-s2.0-0037394420 01/14/2003 115 Citations

Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis. (Tampo Y, Kotamraju S, Chitambar CR, Kalivendi SV, Keszler A, Joseph J, Kalyanaraman B) Circ Res 2003 Jan 10;92(1):56-63 PMID: 12522121 SCOPUS ID: 2-s2.0-0037428060 01/11/2003 141 Citations

Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications. (Zhang H, Bhargava K, Keszler A, Feix J, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 2003 Mar 14;278(11):8969-78 PMID: 12519728 SCOPUS ID: 2-s2.0-0037646515 01/10/2003 63 Citations

Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. (Vásquez-Vivar J, Duquaine D, Whitsett J, Kalyanaraman B, Rajagopalan S) Arterioscler Thromb Vasc Biol 2002 Oct 01;22(10):1655-61 PMID: 12377745 SCOPUS ID: 2-s2.0-0036790604 10/16/2002 108 Citations

Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1. (Konorev EA, Kotamraju S, Zhao H, Kalivendi S, Joseph J, Kalyanaraman B) Free Radic Biol Med 2002 Oct 01;33(7):988 PMID: 12361808 SCOPUS ID: 2-s2.0-0036801924 10/04/2002 60 Citations

Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. (Newman DK, Hoffman S, Kotamraju S, Zhao T, Wakim B, Kalyanaraman B, Newman PJ) Biochem Biophys Res Commun 2002 Sep 06;296(5):1171-9 PMID: 12207897 SCOPUS ID: 2-s2.0-0036392047 09/05/2002 36 Citations

Doxorubicin-induced apoptosis: implications in cardiotoxicity. (Kalyanaraman B, Joseph J, Kalivendi S, Wang S, Konorev E, Kotamraju S) Mol Cell Biochem 2002;234-235(1-2):119-24 PMID: 12162424 SCOPUS ID: 2-s2.0-4243907381 08/07/2002 360 Citations

Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. (Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B) Biochem J 2002 Nov 01;367(Pt 3):729-40 PMID: 12139490 PMCID: PMC1222928 SCOPUS ID: 2-s2.0-0036845841 07/26/2002 247 Citations

The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. (Vásquez-Vivar J, Martásek P, Whitsett J, Joseph J, Kalyanaraman B) Biochem J 2002 Mar 15;362(Pt 3):733-9 PMID: 11879202 PMCID: PMC1222439 SCOPUS ID: 2-s2.0-0037086565 03/07/2002 259 Citations

Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study. (Zhu BZ, Zhao HT, Kalyanaraman B, Frei B) Free Radic Biol Med 2002 Mar 01;32(5):465-73 PMID: 11864786 SCOPUS ID: 2-s2.0-0036489193 02/28/2002 156 Citations

Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis. (Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B) J Biol Chem 2002 May 10;277(19):17179-87 PMID: 11856741 SCOPUS ID: 2-s2.0-0037053406 02/22/2002 195 Citations

Bicarbonate enhances nitration and oxidation reactions in biological systems--role of reactive oxygen and nitrogen species. (Kalyanaraman B, Joseph J, Zhang H) Adv Exp Med Biol 2001;500:175-82 PMID: 11764932 SCOPUS ID: 2-s2.0-0035699909 01/05/2002 5 Citations

Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. (Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B, Parks DA, Barnes S, Darley-Usmar V) Free Radic Biol Med 2001 Dec 15;31(12):1570-81 PMID: 11744331 SCOPUS ID: 2-s2.0-0035893957 12/18/2001 161 Citations

(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments. (Schroeder P, Zhang H, Klotz LO, Kalyanaraman B, Sies H) Biochem Biophys Res Commun 2001 Dec 21;289(5):1334-8 PMID: 11741342 SCOPUS ID: 2-s2.0-0035930940 12/14/2001 32 Citations

Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. (Zhang H, Joseph J, Gurney M, Becker D, Kalyanaraman B) J Biol Chem 2002 Jan 11;277(2):1013-20 PMID: 11682485 SCOPUS ID: 2-s2.0-0037059860 10/30/2001 98 Citations

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. (Vásquez-Vivar J, Whitsett J, Martásek P, Hogg N, Kalyanaraman B) Free Radic Biol Med 2001 Oct 15;31(8):975-85 PMID: 11595382 SCOPUS ID: 2-s2.0-0035887885 10/12/2001 103 Citations

Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium. (Kalivendi SV, Kotamraju S, Zhao H, Joseph J, Kalyanaraman B) J Biol Chem 2001 Dec 14;276(50):47266-76 PMID: 11579094 SCOPUS ID: 2-s2.0-0035861687 10/02/2001 194 Citations

Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. (Zhao H, Joseph J, Zhang H, Karoui H, Kalyanaraman B) Free Radic Biol Med 2001 Sep 01;31(5):599-606 PMID: 11522444 SCOPUS ID: 2-s2.0-0035451497 08/28/2001 349 Citations

Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution. (Zhang H, Joseph J, Feix J, Hogg N, Kalyanaraman B) Biochemistry 2001 Jun 26;40(25):7675-86 PMID: 11412121 SCOPUS ID: 2-s2.0-0035954378 06/20/2001 76 Citations

Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. (Kotamraju S, Hogg N, Joseph J, Keefer LK, Kalyanaraman B) J Biol Chem 2001 May 18;276(20):17316-23 PMID: 11278975 SCOPUS ID: 2-s2.0-0035907359 03/30/2001 66 Citations

Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism. (Baker JE, Contney SJ, Singh R, Kalyanaraman B, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 2001 Feb;33(2):331-41 PMID: 11162137 SCOPUS ID: 2-s2.0-0034976745 02/13/2001 38 Citations

Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID: 11053770 SCOPUS ID: 2-s2.0-0034667740 10/29/2000 63 Citations

Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes. (Konorev EA, Zhang H, Joseph J, Kennedy MC, Kalyanaraman B) Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2424-30 PMID: 11045980 SCOPUS ID: 2-s2.0-0033672336 10/25/2000 17 Citations

Generation of superoxide from nitric oxide synthase. (Vásquez-Vivar J, Kalyanaraman B) FEBS Lett 2000 Sep 22;481(3):305-6 PMID: 11041680 SCOPUS ID: 2-s2.0-0342844298 10/21/2000 34 Citations

Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. (Pritchard KA Jr, Ackerman A, Kalyanaraman B) J Environ Pathol Toxicol Oncol 2000;19(3):251-60 PMID: 10983891 SCOPUS ID: 2-s2.0-0033856353 09/13/2000 37 Citations

Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation. (Konorev EA, Kalyanaraman B, Hogg N) Free Radic Biol Med 2000 Jun 01;28(11):1671-8 PMID: 10938464 SCOPUS ID: 2-s2.0-0034209724 08/12/2000 69 Citations

The use of NO gas in biological systems. (Hogg N, Kalyanaraman B) Methods Mol Biol 1998;100:231-6 PMID: 10907008 SCOPUS ID: 2-s2.0-0032227828 07/25/2000 7 Citations

Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. (Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B) J Biol Chem 2000 Oct 27;275(43):33585-92 PMID: 10899161 SCOPUS ID: 2-s2.0-0034721770 07/19/2000 348 Citations

Peroxynitrite reversibly inhibits Ca(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells. (Brzezinska AK, Gebremedhin D, Chilian WM, Kalyanaraman B, Elliott SJ) Am J Physiol Heart Circ Physiol 2000 Jun;278(6):H1883-90 PMID: 10843885 SCOPUS ID: 2-s2.0-0033947554 06/14/2000 109 Citations

Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications. (Zhang H, Joseph J, Vasquez-Vivar J, Karoui H, Nsanzumuhire C, Martásek P, Tordo P, Kalyanaraman B) FEBS Lett 2000 May 04;473(1):58-62 PMID: 10802059 SCOPUS ID: 2-s2.0-0034604057 05/10/2000 145 Citations

Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation. (Vasquez-Vivar J, Kalyanaraman B, Kennedy MC) J Biol Chem 2000 May 12;275(19):14064-9 PMID: 10799480 SCOPUS ID: 2-s2.0-0039174315 05/09/2000 277 Citations

Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase. Intermediacy of carbonate anion radical. (Zhang H, Joseph J, Felix C, Kalyanaraman B) J Biol Chem 2000 May 12;275(19):14038-45 PMID: 10799477 SCOPUS ID: 2-s2.0-0034640515 05/09/2000 105 Citations

Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):607-17 PMID: 10630684 SCOPUS ID: 2-s2.0-0344146555 01/12/2000 27 Citations

Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications. (Goss SP, Singh RJ, Hogg N, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):597-606 PMID: 10630683 SCOPUS ID: 2-s2.0-0032585706 01/12/2000 55 Citations

Mechanism of superoxide dismutase/H(2)O(2)-mediated nitric oxide release from S-nitrosoglutathione--role of glutamate. (Singh RJ, Hogg N, Goss SP, Antholine WE, Kalyanaraman B) Arch Biochem Biophys 1999 Dec 01;372(1):8-15 PMID: 10562411 SCOPUS ID: 2-s2.0-0033485932 11/24/1999 28 Citations

Bicarbonate enhances the peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical. (Goss SP, Singh RJ, Kalyanaraman B) J Biol Chem 1999 Oct 01;274(40):28233-9 PMID: 10497178 SCOPUS ID: 2-s2.0-0033214459 09/25/1999 89 Citations

Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B) J Biol Chem 1999 Sep 17;274(38):26736-42 PMID: 10480877 SCOPUS ID: 2-s2.0-0040886300 09/10/1999 169 Citations

Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: the role of reactive oxygen and nitrogen intermediates. (Konorev EA, Kennedy MC, Kalyanaraman B) Arch Biochem Biophys 1999 Aug 15;368(2):421-8 PMID: 10441396 SCOPUS ID: 2-s2.0-0033567224 08/12/1999 116 Citations

Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID: 10415535 SCOPUS ID: 2-s2.0-0032773216 07/23/1999 62 Citations

Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. (Patel RP, Hogg N, Spencer NY, Kalyanaraman B, Matalon S, Darley-Usmar VM) J Biol Chem 1999 May 28;274(22):15487-92 PMID: 10336440 SCOPUS ID: 2-s2.0-0033016469 05/21/1999 125 Citations

Nitric oxide and lipid peroxidation. (Hogg N, Kalyanaraman B) Biochim Biophys Acta 1999 May 05;1411(2-3):378-84 PMID: 10320670 SCOPUS ID: 2-s2.0-0032899132 05/13/1999 316 Citations

Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. (Ferguson E, Hogg N, Antholine WE, Joseph J, Singh RJ, Parthasarathy S, Kalyanaraman B) Free Radic Biol Med 1999 Apr;26(7-8):968-77 PMID: 10232841 SCOPUS ID: 2-s2.0-0032953962 05/08/1999 33 Citations

The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. (Goss SP, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1999 Mar 15;363(2):333-40 PMID: 10068456 SCOPUS ID: 2-s2.0-0033558804 03/09/1999 66 Citations

Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. (Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B) Methods Enzymol 1999;301:169-77 PMID: 9919565 SCOPUS ID: 2-s2.0-0031795460 01/27/1999 41 Citations

Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. (Goss SP, Kalyanaraman B, Hogg N) Methods Enzymol 1999;301:444-53 PMID: 9919593 SCOPUS ID: 2-s2.0-0031795335 01/27/1999 24 Citations

Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID: 9889894 SCOPUS ID: 2-s2.0-0032444786 01/16/1999 11 Citations

The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. (Singh RJ, Hogg N, Joseph J, Konorev E, Kalyanaraman B) Arch Biochem Biophys 1999 Jan 15;361(2):331-9 PMID: 9882464 SCOPUS ID: 2-s2.0-0033555139 01/12/1999 132 Citations

Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells. (Janssen YM, Soultanakis R, Steece K, Heerdt E, Singh RJ, Joseph J, Kalyanaraman B) Am J Physiol 1998 Dec;275(6):L1100-9 PMID: 9843847 SCOPUS ID: 2-s2.0-0032415116 12/09/1998 54 Citations

Nitration of gamma-tocopherol and oxidation of alpha-tocopherol by copper-zinc superoxide dismutase/H2O2/NO2-: role of nitrogen dioxide free radical. (Singh RJ, Goss SP, Joseph J, Kalyanaraman B) Proc Natl Acad Sci U S A 1998 Oct 27;95(22):12912-7 PMID: 9789014 PMCID: PMC23652 SCOPUS ID: 2-s2.0-0032573172 10/28/1998 77 Citations

Nitric oxide and low-density lipoprotein oxidation. (Hogg N, Kalyanaraman B) Free Radic Res 1998 Jun;28(6):593-600 PMID: 9736311 SCOPUS ID: 2-s2.0-0031712739 09/15/1998 27 Citations

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. (Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr) Proc Natl Acad Sci U S A 1998 Aug 04;95(16):9220-5 PMID: 9689061 PMCID: PMC21319 SCOPUS ID: 2-s2.0-0032482975 08/05/1998 1256 Citations

Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate. (Nakanishi AL, Roza AM, Adams MB, Seibel R, Moore-Hilton G, Kalyanaraman B, Pieper GM) Free Radic Biol Med 1998 Jul 15;25(2):201-7 PMID: 9667497 SCOPUS ID: 2-s2.0-0032527926 07/17/1998 17 Citations

Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2. (Singh RJ, Karoui H, Gunther MR, Beckman JS, Mason RP, Kalyanaraman B) Proc Natl Acad Sci U S A 1998 Jun 09;95(12):6675-80 PMID: 9618471 PMCID: PMC22595 SCOPUS ID: 2-s2.0-0032499788 06/17/1998 110 Citations

Rapid and irreversible inhibition of creatine kinase by peroxynitrite. (Konorev EA, Hogg N, Kalyanaraman B) FEBS Lett 1998 May 08;427(2):171-4 PMID: 9607305 SCOPUS ID: 2-s2.0-0032496422 06/02/1998 137 Citations

Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-modified low density lipoprotein. (Ferguson E, Parthasarathy S, Joseph J, Kalyanaraman B) J Lipid Res 1998 Apr;39(4):925-33 PMID: 9555955 SCOPUS ID: 2-s2.0-0031969378 04/29/1998 48 Citations

Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. (Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3469-74 PMID: 9437194 SCOPUS ID: 2-s2.0-0031472171 01/23/1998 9 Citations

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. (Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B) Biochemistry 1997 Sep 23;36(38):11293-7 PMID: 9333325 SCOPUS ID: 2-s2.0-19244383998 10/23/1997 313 Citations

The effect of nitric oxide release rates on the oxidation of human low density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) J Biol Chem 1997 Aug 22;272(34):21647-53 PMID: 9261188 SCOPUS ID: 2-s2.0-0030845236 08/22/1997 71 Citations

Spin-trapping of free radicals formed during the oxidation of glutathione by tetramethylammonium peroxynitrite. (Karoui H, Hansert B, Sand PJ, Tordo P, Bohle DS, Kalyanaraman B) Nitric Oxide 1997 Aug;1(4):346-58 PMID: 9441906 SCOPUS ID: 2-s2.0-0031416665 08/01/1997 7 Citations

The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein. (Ferguson E, Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1997 May 15;341(2):287-94 PMID: 9169017 SCOPUS ID: 2-s2.0-0031570305 05/15/1997 21 Citations

S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. (Hogg N, Singh RJ, Konorev E, Joseph J, Kalyanaraman B) Biochem J 1997 Apr 15;323 ( Pt 2)(Pt 2):477-81 PMID: 9163341 PMCID: PMC1218344 SCOPUS ID: 2-s2.0-0030945376 04/15/1997 122 Citations

Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. (Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B) FEBS Lett 1997 Feb 17;403(2):127-30 PMID: 9042951 SCOPUS ID: 2-s2.0-0242502758 02/17/1997 191 Citations

Spin label oximetry to assess extracellular oxygen during myocardial ischemia. (Baker JE, Froncisz W, Joseph J, Kalyanaraman B) Free Radic Biol Med 1997;22(1-2):109-15 PMID: 8958135 SCOPUS ID: 2-s2.0-0029911540 01/01/1997 22 Citations

Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. (Curtis JF, Reddy NG, Mason RP, Kalyanaraman B, Eling TE) Arch Biochem Biophys 1996 Nov 15;335(2):369-76 PMID: 8914934 SCOPUS ID: 2-s2.0-0030588938 11/15/1996 63 Citations

The mechanism of cardioprotection by S-nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest. (Konorev EA, Joseph J, Tarpey MM, Kalyanaraman B) Br J Pharmacol 1996 Oct;119(3):511-8 PMID: 8894171 PMCID: PMC1915698 SCOPUS ID: 2-s2.0-0029787905 10/01/1996 44 Citations

Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols--a high resolution ESR spin-trapping study at Q-band (35 GHz). (Kalyanaraman B, Karoui H, Singh RJ, Felix CC) Anal Biochem 1996 Oct 01;241(1):75-81 PMID: 8921168 SCOPUS ID: 2-s2.0-0030271396 10/01/1996 57 Citations

Mechanism of nitric oxide release from S-nitrosothiols. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 1996 Aug 02;271(31):18596-603 PMID: 8702510 SCOPUS ID: 2-s2.0-0029780524 08/02/1996 531 Citations

The reaction between nitric oxide and alpha-tocopherol: a reappraisal. (Hogg N, Singh RJ, Goss SP, Kalyanaraman B) Biochem Biophys Res Commun 1996 Jul 25;224(3):696-702 PMID: 8713109 SCOPUS ID: 2-s2.0-0030601217 07/25/1996 23 Citations

Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study. (Karoui H, Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1996 Jun 01;330(1):115-24 PMID: 8651684 SCOPUS ID: 2-s2.0-0029947061 06/01/1996 16 Citations

The role of glutathione in the transport and catabolism of nitric oxide. (Hogg N, Singh RJ, Kalyanaraman B) FEBS Lett 1996 Mar 18;382(3):223-8 PMID: 8605974 SCOPUS ID: 2-s2.0-0029927487 03/18/1996 251 Citations

Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. (Karoui H, Hogg N, Fréjaville C, Tordo P, Kalyanaraman B) J Biol Chem 1996 Mar 15;271(11):6000-9 PMID: 8626383 SCOPUS ID: 2-s2.0-0029939154 03/15/1996 220 Citations

S-nitrosoglutathione induces formation of nitrosylmyoglobin in isolated hearts during cardioplegic ischemia--an electron spin resonance study. (Konorev EA, Joseph J, Kalyanaraman B) FEBS Lett 1996 Jan 08;378(2):111-4 PMID: 8549814 SCOPUS ID: 2-s2.0-0030060141 01/08/1996 23 Citations

Detection of nitric oxide by electron spin resonance in chemical, photochemical, cellular, physiological, and pathophysiological systems. (Kalyanaraman B) Methods Enzymol 1996;268:168-87 PMID: 8782583 SCOPUS ID: 2-s2.0-0029819902 01/01/1996 50 Citations

Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. (Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Dec 20;324(2):367-73 PMID: 8554328 SCOPUS ID: 2-s2.0-0029584586 12/20/1995 9 Citations

Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. (Rubbo H, Parthasarathy S, Barnes S, Kirk M, Kalyanaraman B, Freeman BA) Arch Biochem Biophys 1995 Dec 01;324(1):15-25 PMID: 7503550 SCOPUS ID: 2-s2.0-0028793450 12/01/1995 246 Citations

Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors. (Hogg N, Struck A, Goss SP, Santanam N, Joseph J, Parthasarathy S, Kalyanaraman B) J Lipid Res 1995 Aug;36(8):1756-62 PMID: 7595096 SCOPUS ID: 2-s2.0-0029119766 08/01/1995 77 Citations

Detection by ESR of DMPO hydroxyl adduct formation from islets of Langerhans. (Pieper GM, Felix CC, Kalyanaraman B, Turk M, Roza AM) Free Radic Biol Med 1995 Aug;19(2):219-25 PMID: 7649493 SCOPUS ID: 2-s2.0-0029046840 08/01/1995 41 Citations

The antioxidant effect of spermine NONOate in human low-density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) Chem Res Toxicol 1995;8(5):800-6 PMID: 7548764 SCOPUS ID: 2-s2.0-0029024408 07/01/1995 54 Citations

Radical intermediates during degradation of lignin-model compounds and environmental pollutants: an electron spin resonance study. (Kalyanaraman B) Xenobiotica 1995 Jul;25(7):667-75 PMID: 7483665 SCOPUS ID: 2-s2.0-0029118954 07/01/1995 21 Citations

S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) J Pharmacol Exp Ther 1995 Jul;274(1):200-6 PMID: 7616400 SCOPUS ID: 2-s2.0-0029075141 07/01/1995 80 Citations

Spin-labeling study of the oxidative damage to low-density lipoprotein. (Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Jun 20;320(1):155-61 PMID: 7793976 SCOPUS ID: 2-s2.0-0029013080 06/20/1995 23 Citations

Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. (Kalyanaraman B, Darley-Usmar V, Struck A, Hogg N, Parthasarathy S) J Lipid Res 1995 May;36(5):1037-45 PMID: 7658151 SCOPUS ID: 2-s2.0-0028990195 05/01/1995 39 Citations

Is free radical generation an important component of ischemia/reperfusion injury? Part 2. (Kalyanaraman B, Konorev EA, Joseph J, Baker JE) Redox Rep 1995 May;1(3):181-4 PMID: 27414273 05/01/1995

Trapping of nitric oxide formed during photolysis of sodium nitroprusside in aqueous and lipid phases: an electron spin resonance study. (Singh RJ, Hogg N, Neese F, Joseph J, Kalyanaraman B) Photochem Photobiol 1995 Apr;61(4):325-30 PMID: 7740075 SCOPUS ID: 2-s2.0-0029287029 04/01/1995 44 Citations

Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells. (Struck AT, Hogg N, Thomas JP, Kalyanaraman B) FEBS Lett 1995 Mar 20;361(2-3):291-4 PMID: 7698340 SCOPUS ID: 2-s2.0-0028956707 03/20/1995 63 Citations

Photosensitized decomposition of S-nitrosothiols and 2-methyl-2-nitrosopropane. Possible use for site-directed nitric oxide production. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) FEBS Lett 1995 Feb 20;360(1):47-51 PMID: 7875299 SCOPUS ID: 2-s2.0-0029648407 02/20/1995 83 Citations

Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) Free Radic Biol Med 1995 Feb;18(2):169-77 PMID: 7744299 SCOPUS ID: 2-s2.0-0028796439 02/01/1995 35 Citations

Reactions of nitric oxide with nitronyl nitroxides and oxygen: prediction of nitrite and nitrate formation by kinetic simulation. (Hogg N, Singh RJ, Joseph J, Neese F, Kalyanaraman B) Free Radic Res 1995 Jan;22(1):47-56 PMID: 7889147 SCOPUS ID: 2-s2.0-0029182684 01/01/1995 70 Citations

Thiyl radicals in biological systems: significant or trivial? (Kalyanaraman B) Biochem Soc Symp 1995;61:55-63 PMID: 8660403 SCOPUS ID: 2-s2.0-0029438532 01/01/1995 44 Citations

Physical and chemical interactions between nitric oxide and nitroxides. (Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B) Biochim Biophys Acta 1994 Dec 15;1201(3):437-41 PMID: 7803474 SCOPUS ID: 2-s2.0-0028091445 12/15/1994 24 Citations

Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein. (Thomas JP, Kalyanaraman B, Girotti AW) Arch Biochem Biophys 1994 Dec;315(2):244-54 PMID: 7986064 SCOPUS ID: 2-s2.0-0027974212 12/01/1994 97 Citations

Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps. (Thomas CE, Ohlweiler DF, Kalyanaraman B) J Biol Chem 1994 Nov 11;269(45):28055-61 PMID: 7961741 SCOPUS ID: 2-s2.0-0028104414 11/11/1994 27 Citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. (Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA) J Biol Chem 1994 Oct 21;269(42):26066-75 PMID: 7929318 SCOPUS ID: 2-s2.0-0028151406 10/21/1994 1283 Citations

The oxidation of alpha-tocopherol and trolox by peroxynitrite. (Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1994 Oct;314(1):153-8 PMID: 7944387 SCOPUS ID: 2-s2.0-0028172263 10/01/1994 102 Citations

Enhancement of merocyanine 540 uptake and photodynamic cell killing by salicylates. (Feix JB, Anderson MS, Kalyanaraman B) Cancer Res 1994 Jul 01;54(13):3474-8 PMID: 8012969 SCOPUS ID: 2-s2.0-0028234320 07/01/1994 4 Citations

Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes. (Thomas CE, Ku G, Kalyanaraman B) J Lipid Res 1994 Apr;35(4):610-9 PMID: 8006515 SCOPUS ID: 2-s2.0-0028345122 04/01/1994 19 Citations

Lack of protection of PBN in isolated heart during ischemia and reperfusion: implications for radical scavenging mechanism. (Baker JE, Konorev EA, Tse SY, Joseph J, Kalyanaraman B) Free Radic Res 1994 Mar;20(3):145-63 PMID: 8019639 SCOPUS ID: 2-s2.0-0028215452 03/01/1994 10 Citations

Radical generation and detection in myocardial injury (Kalyanaraman B, Konorev EA, Joseph J, Baker JE) New Comprehensive Biochemistry 1 January 1994;28(C):333-359 SCOPUS ID: 2-s2.0-77956861027 01/01/1994 10 Citations

Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. (Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S) FEBS Lett 1993 Nov 15;334(2):170-4 PMID: 8224243 SCOPUS ID: 2-s2.0-0027527402 11/15/1993 373 Citations

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. (Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S) FEBS Lett 1993 Sep 13;330(2):181-5 PMID: 8365489 SCOPUS ID: 2-s2.0-0027162279 09/13/1993 258 Citations

Spin trapping of nitrogen dioxide radical from photolytic decomposition of nitramines. (Pace MD, Kalyanaraman B) Free Radic Biol Med 1993 Sep;15(3):337-42 PMID: 8406133 SCOPUS ID: 2-s2.0-0027168962 09/01/1993 16 Citations

Site-specific trapping of reactive species in low-density lipoprotein oxidation: biological implications. (Kalyanaraman B, Joseph J, Parthasarathy S) Biochim Biophys Acta 1993 Jun 12;1168(2):220-7 PMID: 8389205 SCOPUS ID: 2-s2.0-0027294970 06/12/1993 14 Citations

Free radicals in toxicology. (Aust SD, Chignell CF, Bray TM, Kalyanaraman B, Mason RP) Toxicol Appl Pharmacol 1993 Jun;120(2):168-78 PMID: 8511786 SCOPUS ID: 2-s2.0-0027161760 06/01/1993 172 Citations

The use of spin traps to investigate site-specific formation of free radicals in low-density lipoprotein oxidation. (Kalyanaraman B, Joseph J, Parthasarathy S) Biochem Soc Trans 1993 May;21(2):318-21 PMID: 8395423 SCOPUS ID: 2-s2.0-0027269801 05/01/1993 11 Citations

Trapping of nitric oxide by nitronyl nitroxides: an electron spin resonance investigation. (Joseph J, Kalyanaraman B, Hyde JS) Biochem Biophys Res Commun 1993 Apr 30;192(2):926-34 PMID: 8387295 SCOPUS ID: 2-s2.0-0027284404 04/30/1993 136 Citations

Enhancement of merocyanine 540-mediated phototherapy by salicylate. (Anderson MS, Kalyanaraman B, Feix JB) Cancer Res 1993 Feb 15;53(4):806-9 PMID: 8381329 SCOPUS ID: 2-s2.0-0027474458 02/15/1993 10 Citations

Vasodilatory and toxic effects of spin traps on aerobic cardiac function. (Konorev EA, Baker JE, Joseph J, Kalyanaraman B) Free Radic Biol Med 1993 Feb;14(2):127-37 PMID: 8425719 SCOPUS ID: 2-s2.0-0027473299 02/01/1993 66 Citations

Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries. (Konorev EA, Struck AT, Baker JE, Ramanujam S, Thomas JP, Radi R, Kalyanaraman B) Free Radic Res Commun 1993;19(6):397-407 PMID: 8168729 SCOPUS ID: 2-s2.0-0027759676 01/01/1993 12 Citations

Direct modification of low density lipoprotein by the spin trap 3,5-dibromo-4-nitrosobenzenesulfonic acid. (Kalyanaraman B, Joseph J, Kondratenko N, Parthasarathy S) Biochim Biophys Acta 1992 Jun 26;1126(3):309-13 PMID: 1322177 SCOPUS ID: 2-s2.0-0026724021 06/26/1992 10 Citations

Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine. (Sugumaran M, Semensi V, Kalyanaraman B, Bruce JM, Land EJ) J Biol Chem 1992 May 25;267(15):10355-61 PMID: 1316899 SCOPUS ID: 2-s2.0-0026727777 05/25/1992 57 Citations

Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein. (Kalyanaraman B, Darley-Usmar VM, Wood J, Joseph J, Parthasarathy S) J Biol Chem 1992 Apr 05;267(10):6789-95 PMID: 1313022 SCOPUS ID: 2-s2.0-0026757160 04/05/1992 76 Citations

Photobleaching of merocyanine 540: involvement of singlet molecular oxygen. (Singh RJ, Feix JB, Kalyanaraman B) Photochem Photobiol 1992 Apr;55(4):483-9 PMID: 1620725 SCOPUS ID: 2-s2.0-0026847607 04/01/1992 22 Citations

Production of singlet oxygen-derived hydroxyl radical adducts during merocyanine-540-mediated photosensitization: analysis by ESR-spin trapping and HPLC with electrochemical detection. (Feix JB, Kalyanaraman B) Arch Biochem Biophys 1991 Nov 15;291(1):43-51 PMID: 1656888 SCOPUS ID: 2-s2.0-0025836735 11/15/1991 66 Citations

Action spectra of the antileukemic and antiviral activities of merocyanine 540. (O'Brien JM, Singh RJ, Feix JB, Kalyanaraman B, Sieber F) Photochem Photobiol 1991 Nov;54(5):851-4 PMID: 1665914 SCOPUS ID: 2-s2.0-0026251576 11/01/1991 21 Citations

Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones. (Roy D, Kalyanaraman B, Liehr JG) Biochem Pharmacol 1991 Sep 27;42(8):1627-31 PMID: 1656992 SCOPUS ID: 2-s2.0-0025813582 09/27/1991 26 Citations

Detection of radical adducts of 5,5-dimethyl-1-pyrroline n-oxide by the combined use of high-performance liquid chromatography with electrochemical detection and electron spin resonance. (Towell J, Kalyanaraman B) Anal Biochem 1991 Jul;196(1):111-9 PMID: 1653547 SCOPUS ID: 2-s2.0-0025740278 07/01/1991 38 Citations

Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields. (Singh RJ, Feix JB, Pintar TJ, Girotti AW, Kalyanaraman B) Photochem Photobiol 1991 Apr;53(4):493-500 PMID: 1857744 SCOPUS ID: 2-s2.0-0026149992 04/01/1991 37 Citations

An electron paramagnetic resonance study of the interactions between the adriamycin semiquinone, hydrogen peroxide, iron-chelators, and radical scavengers. (Kalyanaraman B, Morehouse KM, Mason RP) Arch Biochem Biophys 1991 Apr;286(1):164-70 PMID: 1654778 SCOPUS ID: 2-s2.0-0025817761 04/01/1991 56 Citations

Characterization of the pigment from homogentisic acid and urine and tissue from an alkaptonuria patient. (Menon IA, Persad SD, Haberman HF, Basu PK, Norfray JF, Felix CC, Kalyanaraman B) Biochem Cell Biol 1991 Apr;69(4):269-73 PMID: 1647170 SCOPUS ID: 2-s2.0-0026149212 04/01/1991 27 Citations

The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein. (Kalyanaraman B, Joseph J, Parthasarathy S) FEBS Lett 1991 Mar 11;280(1):17-20 PMID: 1849092 SCOPUS ID: 2-s2.0-0026071271 03/11/1991 44 Citations

Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer. (Antholine WE, Kalyanaraman B, Templin JA, Byrnes RW, Petering DH) Free Radic Biol Med 1991;10(2):119-23 PMID: 1707847 SCOPUS ID: 2-s2.0-0025974431 01/01/1991 21 Citations

An electron spin resonance study of merocyanine 540-mediated type I reactions in liposomes. (Feix JB, Kalyanaraman B) Photochem Photobiol 1991 Jan;53(1):39-45 PMID: 1851304 SCOPUS ID: 2-s2.0-0025928466 01/01/1991 19 Citations

Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs. (Maruyama M, Pieper GM, Kalyanaraman B, Hallaway PE, Hedlund BE, Gross GJ) J Cardiovasc Pharmacol 1991 Jan;17(1):166-75 PMID: 1708051 SCOPUS ID: 2-s2.0-0026007641 01/01/1991 30 Citations

Lignin peroxidase oxidation of Mn2+ in the presence of veratryl alcohol, malonic or oxalic acid, and oxygen. (Popp JL, Kalyanaraman B, Kirk TK) Biochemistry 1990 Nov 20;29(46):10475-80 PMID: 2176868 SCOPUS ID: 2-s2.0-0025202423 11/20/1990 120 Citations

Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide. (Sinha BK, Antholine WM, Kalyanaraman B, Eliot HM) Biochim Biophys Acta 1990 Nov 14;1096(1):81-3 PMID: 2176549 SCOPUS ID: 2-s2.0-0026097884 11/14/1990 22 Citations

Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study. (Kalyanaraman B, Antholine WE, Parthasarathy S) Biochim Biophys Acta 1990 Sep 14;1035(3):286-92 PMID: 2169886 SCOPUS ID: 2-s2.0-0024991120 09/14/1990 45 Citations

Characterization of radical adducts formed during photochemical spin trapping in liposomes. (Sheng PG, Feix J, Kalyanaraman B) Photochem Photobiol 1990 Aug;52(2):323-31 PMID: 2171003 SCOPUS ID: 2-s2.0-0025469328 08/01/1990 4 Citations

Comparison of lignin peroxidase, horseradish peroxidase and laccase in the oxidation of methoxybenzenes. (Kersten PJ, Kalyanaraman B, Hammel KE, Reinhammar B, Kirk TK) Biochem J 1990 Jun 01;268(2):475-80 PMID: 2163614 PMCID: PMC1131457 SCOPUS ID: 2-s2.0-0025341273 06/01/1990 321 Citations

On the detection of paramagnetic species in the adriamycin-perfused rat heart: a reappraisal. (Kalyanaraman B, Baker JE) Biochem Biophys Res Commun 1990 May 31;169(1):30-8 PMID: 2161659 SCOPUS ID: 2-s2.0-0025333513 05/31/1990 2 Citations

An ESR study of the nitroxide radical of pentastarch-conjugated deferoxamine. (Pieper GM, Gross GJ, Kalyanaraman B) Free Radic Biol Med 1990;9(3):211-8 PMID: 2177027 SCOPUS ID: 2-s2.0-0025064707 01/01/1990 15 Citations

Characterization of o-semiquinone radicals in biological systems. (Kalyanaraman B) Methods Enzymol 1990;186:333-43 PMID: 2172710 SCOPUS ID: 2-s2.0-0025033427 01/01/1990 53 Citations

Lignin peroxidase from fungi: Phanerochaete chrysosporium (Kent Kirk T, Tien M, Kersten PJ, Kalyanaraman B, Hammel KE, Farrell RL) Methods in Enzymology 1 January 1990;188(C):159-171 SCOPUS ID: 2-s2.0-0025051375 01/01/1990 42 Citations

Spin trapping of lipid-derived radicals in liposomes. (Feix JB, Kalyanaraman B) Biochim Biophys Acta 1989 Aug 18;992(2):230-5 PMID: 2547451 SCOPUS ID: 2-s2.0-0024346387 08/18/1989 19 Citations

Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study. (Athar M, Mukhtar H, Bickers DR, Khan IU, Kalyanaraman B) Carcinogenesis 1989 Aug;10(8):1499-503 PMID: 2473853 SCOPUS ID: 2-s2.0-0024336057 08/01/1989 57 Citations

Characterization of semiquinone free radicals formed from stilbene catechol estrogens. An ESR spin stabilization and spin trapping study. (Kalyanaraman B, Sealy RC, Liehr JG) J Biol Chem 1989 Jul 05;264(19):11014-9 PMID: 2544580 SCOPUS ID: 2-s2.0-0024406075 07/05/1989 28 Citations

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR Study. (Kalyanaraman B, Nemec J, Sinha BK) Biochemistry 1989 May 30;28(11):4839-46 PMID: 2548593 SCOPUS ID: 2-s2.0-0024372292 05/30/1989 73 Citations

Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. (Baker JE, Kalyanaraman B) FEBS Lett 1989 Feb 27;244(2):311-4 PMID: 2537756 SCOPUS ID: 2-s2.0-0024561513 02/27/1989 43 Citations

Direct observation of singlet oxygen production by merocyanine 540 associated with phosphatidylcholine liposomes. (Feix JB, Kalyanaraman B, Chignell CF, Hall RD) J Biol Chem 1988 Nov 25;263(33):17247-50 PMID: 3182846 SCOPUS ID: 2-s2.0-0024242683 11/25/1988 41 Citations

Reaction between ortho-semiquinones and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies. (Kalyanaraman B, Korytowski W, Pilas B, Sarna T, Land EJ, Truscott TG) Arch Biochem Biophys 1988 Oct;266(1):277-84 PMID: 2845864 SCOPUS ID: 2-s2.0-0023720112 10/01/1988 35 Citations

Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study. (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1988 Jul 29;154(2):781-8 PMID: 2840906 SCOPUS ID: 2-s2.0-0023742708 07/29/1988 11 Citations

Ligninase-mediated phenoxy radical formation and polymerization unaffected by cellobiose:quinone oxidoreductase. (Odier E, Mozuch MD, Kalyanaraman B, Kirk TK) Biochimie 1988 Jun;70(6):847-52 PMID: 2844307 SCOPUS ID: 2-s2.0-0023729086 06/01/1988 52 Citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy. (Baker JE, Felix CC, Olinger GN, Kalyanaraman B) Proc Natl Acad Sci U S A 1988 Apr;85(8):2786-9 PMID: 2833754 PMCID: PMC280084 SCOPUS ID: 2-s2.0-0007472414 04/01/1988 197 Citations

The effect of melanin on iron associated decomposition of hydrogen peroxide. (Pilas B, Sarna T, Kalyanaraman B, Swartz HM) Free Radic Biol Med 1988;4(5):285-93 PMID: 2834276 SCOPUS ID: 2-s2.0-0023884694 01/01/1988 124 Citations

Mechanism of oxidation of 1-methyl-4-phenyl-3,3-dihydropyridinium (MPDP+). (Kalyanaraman B, Korytowski W, Felix CC) Basic Life Sci 1988;49:781-5 PMID: 3250532 SCOPUS ID: 2-s2.0-0024235656 01/01/1988

The production of hydroxyl and semiquinone free radicals during the autoxidation of redox active flavonoids. (Hodnick WF, Kalyanaraman B, Pritsos CA, Pardini RS) Basic Life Sci 1988;49:149-52 PMID: 2854978 SCOPUS ID: 2-s2.0-0024200896 01/01/1988 34 Citations

Serial spousal directed blood donations. (Kolins MD) Transfusion 1987;27(6):503 PMID: 3686663 SCOPUS ID: 2-s2.0-0023442523 11/01/1987

Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1987 Aug 31;147(1):354-60 PMID: 3632675 SCOPUS ID: 2-s2.0-0023669405 08/31/1987 9 Citations

Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study. (Kalyanaraman B, Premovic PI, Sealy RC) J Biol Chem 1987 Aug 15;262(23):11080-7 PMID: 3038907 SCOPUS ID: 2-s2.0-0023655814 08/15/1987 147 Citations

Is there any difference in the photobiological properties of melanins isolated from human blue and brown eyes? (Menon IA, Basu PK, Persad S, Avaria M, Felix CC, Kalyanaraman B) Br J Ophthalmol 1987 Jul;71(7):549-52 PMID: 2820463 PMCID: PMC1041224 SCOPUS ID: 2-s2.0-0023268431 07/01/1987 17 Citations

Tyrosinase-catalyzed oxidation of dopa and related catechol(amine)s: a kinetic electron spin resonance investigation using spin-stabilization and spin label oximetry. (Korytowski W, Sarna T, Kalyanaraman B, Sealy RC) Biochim Biophys Acta 1987 Jun 22;924(3):383-92 PMID: 3036239 SCOPUS ID: 2-s2.0-0023662391 06/22/1987 67 Citations

Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. (Kalyanaraman B, Feix JB, Sieber F, Thomas JP, Girotti AW) Proc Natl Acad Sci U S A 1987 May;84(9):2999-3003 PMID: 3033673 PMCID: PMC304788 SCOPUS ID: 2-s2.0-0011230888 05/01/1987 173 Citations

Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1987 Apr 29;144(2):692-8 PMID: 3579936 SCOPUS ID: 2-s2.0-0023229054 04/29/1987 16 Citations

Photoinduced generation of hydrogen peroxide and hydroxyl radicals in melanins. (Korytowski W, Pilas B, Sarna T, Kalyanaraman B) Photochem Photobiol 1987 Feb;45(2):185-90 PMID: 3031709 SCOPUS ID: 2-s2.0-0023282277 02/01/1987 153 Citations

Interactions of the antitumor drug, etoposide, with reduced thiols in vitro and in vivo. (Katki AG, Kalyanaraman B, Sinha BK) Chem Biol Interact 1987;62(3):237-47 PMID: 3040275 SCOPUS ID: 2-s2.0-0023266733 01/01/1987 31 Citations

Effects of diazepam on human laboratory aggression: correlations with alcohol effects and hostility measures. (Cherek DR, Steinberg JL, Kelly TH) NIDA Res Monogr 1987;76:95-101 PMID: 3125473 SCOPUS ID: 2-s2.0-0023484212 01/01/1987 2 Citations

One-Electron Reduction of Daunomycin, Daunomycinone, and 7-Deoxydaunomycinone by the Xanthine/Xanthine Oxidase System: Detection of Semiquinone Free Radicals by Electron Spin Resonance (Schreiber J, Mottley C, Sinha BK, Kalyanaraman B, Mason RP) Journal of the American Chemical Society 1 January 1987;109(2):348-351 SCOPUS ID: 2-s2.0-0023135069 01/01/1987 67 Citations

Oxidation of polycyclic aromatic hydrocarbons and dibenzo[p]-dioxins by Phanerochaete chrysosporium ligninase. (Hammel KE, Kalyanaraman B, Kirk TK) J Biol Chem 1986 Dec 25;261(36):16948-52 PMID: 3023375 SCOPUS ID: 2-s2.0-0022968235 12/25/1986 356 Citations

Photolysis of pheomelanin precursors: an ESR-spin trapping study. (Pilas B, Felix CC, Sarna T, Kalyanaraman B) Photochem Photobiol 1986 Dec;44(6):689-96 PMID: 3031704 SCOPUS ID: 2-s2.0-0022842952 12/01/1986 15 Citations

The use of spin label oximetry in the study of photodynamic inactivation of Chinese hamster ovary cells. (Ankel E, Felix CC, Kalyanaraman B) Photochem Photobiol 1986 Dec;44(6):741-6 PMID: 3031706 SCOPUS ID: 2-s2.0-0022826010 12/01/1986 2 Citations

An electron spin resonance study of free radicals from catechol estrogens. (Kalyanaraman B, Hintz P, Sealy RC) Fed Proc 1986 Sep;45(10):2477-84 PMID: 3017766 SCOPUS ID: 2-s2.0-0022460299 09/01/1986 19 Citations

Metal ion-induced activation of molecular oxygen in pigmented polymers. (Hintz P, Kalyanaraman B) Biochim Biophys Acta 1986 Aug 06;883(1):41-5 PMID: 3015234 SCOPUS ID: 2-s2.0-0022530208 08/06/1986 18 Citations

Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. (Korytowski W, Kalyanaraman B, Menon IA, Sarna T, Sealy RC) Biochim Biophys Acta 1986 Jun 19;882(2):145-53 PMID: 3011111 SCOPUS ID: 2-s2.0-0023052763 06/19/1986 100 Citations

Substrate free radicals are intermediates in ligninase catalysis. (Hammel KE, Kalyanaraman B, Kirk TK) Proc Natl Acad Sci U S A 1986 Jun;83(11):3708-12 PMID: 3012530 PMCID: PMC323592 SCOPUS ID: 2-s2.0-0142020040 06/01/1986 75 Citations

Ligninase of Phanerochaete chrysosporium. Mechanism of its degradation of the non-phenolic arylglycerol beta-aryl ether substructure of lignin. (Kirk TK, Tien M, Kersten PJ, Mozuch MD, Kalyanaraman B) Biochem J 1986 May 15;236(1):279-87 PMID: 3024619 PMCID: PMC1146817 SCOPUS ID: 2-s2.0-0022641370 05/15/1986 154 Citations

ESR of copper and iron complexes with antitumor and cytotoxic properties. (Antholine WE, Kalyanaraman B, Petering DH) Environ Health Perspect 1985 Dec;64:19-35 PMID: 2420582 PMCID: PMC1568621 SCOPUS ID: 2-s2.0-0022272168 12/01/1985 47 Citations

Semiquinone anion radicals of catechol(amine)s, catechol estrogens, and their metal ion complexes. (Kalyanaraman B, Felix CC, Sealy RC) Environ Health Perspect 1985 Dec;64:185-98 PMID: 3007089 PMCID: PMC1568593 SCOPUS ID: 2-s2.0-0022272166 12/01/1985 152 Citations

Free radical-mediated activation of hydrazine derivatives. (Kalyanaraman B, Sinha BK) Environ Health Perspect 1985 Dec;64:179-84 PMID: 3007088 PMCID: PMC1568606 SCOPUS ID: 2-s2.0-0022272164 12/01/1985 50 Citations

Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. (Sinha BK, Strong J, Gibson NW, Kalyanaraman B) Biochem Pharmacol 1985 Nov 01;34(21):3845-52 PMID: 4062959 SCOPUS ID: 2-s2.0-0022380022 11/01/1985 13 Citations

Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments. (Korytowski W, Hintz P, Sealy RC, Kalyanaraman B) Biochem Biophys Res Commun 1985 Sep 16;131(2):659-65 PMID: 2996521 SCOPUS ID: 2-s2.0-0022407173 09/16/1985 56 Citations

Mechanism of oxidative C alpha-C beta cleavage of a lignin model dimer by Phanerochaete chrysosporium ligninase. Stoichiometry and involvement of free radicals. (Hammel KE, Tien M, Kalyanaraman B, Kirk TK) J Biol Chem 1985 Jul 15;260(14):8348-53 PMID: 2989288 SCOPUS ID: 2-s2.0-0022253244 07/15/1985 138 Citations

Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): implications for mode of action. (Sinha BK, Trush MA, Kalyanaraman B) Biochem Pharmacol 1985 Jun 01;34(11):2036-40 PMID: 4004921 SCOPUS ID: 2-s2.0-0022257532 06/01/1985 34 Citations

Radical anions from one-electron-reduced adrenochrome. Detection and identification by electron spin resonance spectroscopy. (Prabhananda BS, Kalyanaraman B, Sealy RC) Biochim Biophys Acta 1985 May 29;840(1):21-8 PMID: 2986709 SCOPUS ID: 2-s2.0-0021849555 05/29/1985 9 Citations

Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants. (Kalyanaraman B, Sohnle PG) J Clin Invest 1985 May;75(5):1618-22 PMID: 2987307 PMCID: PMC425503 SCOPUS ID: 2-s2.0-0021825352 05/01/1985 112 Citations

Spin trapping of the azidyl radical in azide/catalase/H2O2 and various azide/peroxidase/H2O2 peroxidizing systems. (Kalyanaraman B, Janzen EG, Mason RP) J Biol Chem 1985 Apr 10;260(7):4003-6 PMID: 2984193 SCOPUS ID: 2-s2.0-0021954649 04/10/1985 107 Citations

Free radicals from the photodecomposition of bleomycin. (Antholine WE, Sarna T, Sealy RC, Kalyanaraman B, Shields GD, Petering DH) Photochem Photobiol 1985 Apr;41(4):393-9 PMID: 2409563 SCOPUS ID: 2-s2.0-0022049432 04/01/1985 8 Citations

The ligninase of Phanerochaete chrysosporium generates cation radicals from methoxybenzenes. (Kersten PJ, Tien M, Kalyanaraman B, Kirk TK) J Biol Chem 1985 Mar 10;260(5):2609-12 PMID: 2982828 SCOPUS ID: 2-s2.0-0021910164 03/10/1985 293 Citations

An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens. (Kalyanaraman B, Sealy RC, Sivarajah K) J Biol Chem 1984 Nov 25;259(22):14018-22 PMID: 6094535 SCOPUS ID: 2-s2.0-0021742265 11/25/1984 62 Citations

Identification by electron spin resonance spectroscopy of free radicals produced during autoxidative melanogenesis. (Sealy RC, Puzyna W, Kalyanaraman B, Felix CC) Biochim Biophys Acta 1984 Aug 21;800(3):269-76 PMID: 6087915 SCOPUS ID: 2-s2.0-0021144551 08/21/1984 27 Citations

An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones. (Kalyanaraman B, Sealy RC, Sinha BK) Biochim Biophys Acta 1984 Jun 29;799(3):270-5 PMID: 6329317 SCOPUS ID: 2-s2.0-0021185940 06/29/1984 83 Citations

Peroxidatic oxidation of catecholamines. A kinetic electron spin resonance investigation using the spin stabilization approach. (Kalyanaraman B, Felix CC, Sealy RC) J Biol Chem 1984 Jun 25;259(12):7584-9 PMID: 6330064 SCOPUS ID: 2-s2.0-0021251344 06/25/1984 72 Citations

On the use of organic extraction in the spin-trapping technique as applied to biological systems. (Kalyanaraman B, Mottley C, Mason RP) J Biochem Biophys Methods 1984 Mar;9(1):27-31 PMID: 6327794 SCOPUS ID: 2-s2.0-0021403110 03/01/1984 25 Citations

Electron spin resonance-spin stabilization of semiquinones produced during oxidation of epinephrine and its analogues. (Kalyanaraman B, Felix CC, Sealy RC) J Biol Chem 1984 Jan 10;259(1):354-8 PMID: 6323406 SCOPUS ID: 2-s2.0-0021759138 01/10/1984 75 Citations

Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation. (Sinha BK, Trush MA, Kalyanaraman B) Biochem Pharmacol 1983 Nov 15;32(22):3495-8 PMID: 6651872 SCOPUS ID: 2-s2.0-0021023662 11/15/1983 53 Citations

A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. (Kalyanaraman B, Sivarajah K, Eling TE, Mason RP) Carcinogenesis 1983 Oct;4(10):1341-3 PMID: 6311452 SCOPUS ID: 2-s2.0-0021082301 10/01/1983 16 Citations

A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. (Kalyanaraman B, Mottley C, Mason RP) J Biol Chem 1983 Mar 25;258(6):3855-8 PMID: 6300059 SCOPUS ID: 2-s2.0-0020524329 03/25/1983 122 Citations

Electron spin resonance--spin stabilization in enzymatic systems: detection of semiquinones produced during peroxidatic oxidation of catechols and catecholamines. (Kalyanaraman B, Sealy RC) Biochem Biophys Res Commun 1982 Jun 30;106(4):1119-25 PMID: 6288039 SCOPUS ID: 2-s2.0-0020493768 06/30/1982 62 Citations

The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived. (Kalyanaraman B, Mason RP, Tainer B, Eling TE) J Biol Chem 1982 May 10;257(9):4764-8 PMID: 6279648 SCOPUS ID: 2-s2.0-0020479052 05/10/1982 55 Citations

An electron spin resonance study of the novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazine. (Kalyanaraman B, Mason RP, Sivarajah K) Biochem Biophys Res Commun 1982 Mar 15;105(1):217-24 PMID: 6284143 SCOPUS ID: 2-s2.0-0020482864 03/15/1982 11 Citations

Spin trapping artifacts due to the reduction of nitroso spin traps (Mottley C, Kalyanaraman B, Mason RP) FEBS Letters 20 July 1981;130(1):12-14 SCOPUS ID: 2-s2.0-34247273950 07/20/1981 13 Citations

SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—II. SPIN TRAPPING OF PHOTOLYSIS PRODUCTS FROM SULFANILAMIDE AND 4‐AMINOBENZOIC ACID USING 5,5‐DIMETHYL‐1‐PYRROLINE‐1‐OXIDE (Chignell CF, Kalyanaraman B, Sik RH, Mason RP) Photochemistry and Photobiology August 1981;34(2):147-156 SCOPUS ID: 2-s2.0-84985478221 01/01/1981 56 Citations

SPECTROSCOPIC STUDIES OF CUTANEOUS PHOTOSENSITIZING AGENTS—I. SPIN TRAPPING OF PHOTOLYSIS PRODUCTS FROM SULFANILAMIDE, 4‐AMINOBENZOIC ACID AND RELATED COMPOUNDS (Chignell CF, Kalyanaraman B, Mason RP, Sik RH) Photochemistry and Photobiology November 1980;32(5):563-571 SCOPUS ID: 2-s2.0-0019155988 01/01/1980 72 Citations

The reduction of nitroso-spin traps in chemical and biological sysetms. A cautionary note (Kalyanaraman B, Perez-Reyes E, Mason RP) Tetrahedron Letters 1979;20(50):4809-4812 SCOPUS ID: 2-s2.0-0001325401 01/01/1979 44 Citations

[Proceedings: Effect of glucagon on biosynthesis of cholesterol in the liver]. (Ukai M, Tomura A, Ito M) Nihon Naibunpi Gakkai Zasshi 1974 Feb 20;50(2):647 PMID: 4476640 SCOPUS ID: 2-s2.0-0016397882 02/20/1974

[Sanitary and hygienic evaluation of water desalinated by the EDUM-300-2 electrodialysis installation]. (Anan'ev NI, Demin NA) Gig Sanit 1971;36(2):89-90 PMID: 4253647 SCOPUS ID: 2-s2.0-19244377213 01/01/1971

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Balaraman Kalyanaraman PhD

Professor

Publications (444)