Hemodynamic actions of nicorandil, a new antianginal agent, in the conscious dog. J Cardiovasc Pharmacol 1985;7(4):709-14
Date
07/01/1985Pubmed ID
2410712DOI
10.1097/00005344-198507000-00015Scopus ID
2-s2.0-0021877174 (requires institutional sign-in at Scopus site) 38 CitationsAbstract
We studied the hemodynamic effects of nicorandil (SG-75) and nitroglycerin in conscious dogs before and after beta-adrenergic receptor blockade. Nicorandil (25-300 micrograms/kg/min) and nitroglycerin (5-60 micrograms/kg/min) produced increases in heart rate and decreases in aortic and left ventricular pressures. In the doses studied, nicorandil caused greater decreases in aortic and left ventricular systolic pressure than nitroglycerin; however, nitroglycerin reduced left ventricular end-diastolic pressure to a greater degree. Nicorandil but not nitroglycerin produced an increase in cardiac output secondary to an increase in heart rate. Global contractility (peak positive dP/dt) was increased in a dose-related manner during nicorandil infusion before beta-blockade. In spite of marked hypotensive responses to higher doses, mean coronary blood flow and coronary conductance were increased by nicorandil. In contrast, both parameters were reduced during nitroglycerin infusion. The effects of nicorandil on coronary blood flow were unaltered by beta-adrenergic blockade, suggesting that metabolic autoregulation is not an important mediator of the response. Nicorandil (75-300 micrograms/kg/min) produced a dose-related increase in transmural myocardial blood flow with the greatest increases in perfusion occurring in the subepicardium and midmyocardium. The results of the present study demonstrate that despite structural similarities, nicorandil and nitroglycerin have varying hemodynamic spectra.
Author List
Preuss KC, Gross GJ, Brooks HL, Warltier DCMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cardiac Output
Coronary Circulation
Dogs
Female
Heart Rate
Hemodynamics
Male
Niacinamide
Nicorandil
Nitroglycerin
Propranolol
Time Factors
Vasodilator Agents
