Medical College of Wisconsin
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Cardiotonic effects of anthopleurin-A (AP-A), a polypeptide from a sea anemone, in dogs with a coronary artery stenosis. Eur J Pharmacol 1985 Apr 02;110(2):271-6

Date

04/02/1985

Pubmed ID

3987818

DOI

10.1016/0014-2999(85)90223-7

Scopus ID

2-s2.0-0021814522 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function. AP-A (1.5-5.0 micrograms/kg, i.v.) produced positive inotropic effects globally (dP/dt, 1700 +/- 100 to 2650 +/- 250 mm Hg/s) and locally in the ischemic zone (%SS, 6.7 +/- 1.7 to 13.7 +/- 1.5%) without changing heart rate, mean arterial pressure or myocardial blood flow. These data suggest that AP-A may be potentially useful in the management of heart failure.

Author List

Gross GJ, Warltier DC, Hardman HF, Shibata S

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Cardiotonic Agents
Coronary Circulation
Coronary Disease
Dogs
Female
Heart Rate
Intercellular Signaling Peptides and Proteins
Male
Myocardial Contraction
Peptides