Radiation as a risk factor for cardiovascular disease. Antioxid Redox Signal 2011 Oct 01;15(7):1945-56
Date
11/26/2010Pubmed ID
21091078Pubmed Central ID
PMC3159113DOI
10.1089/ars.2010.3742Scopus ID
2-s2.0-80052015096 (requires institutional sign-in at Scopus site) 106 CitationsAbstract
Abstract population are ubiquitous background radiation and medical exposure of patients. From the early 1980s to 2006, the average dose per individual in the United States for all sources of radiation increased by a factor of 1.7-6.2 mSv, with this increase due to the growth of medical imaging procedures. Radiation can place individuals at an increased risk of developing cardiovascular disease. Excess risk of cardiovascular disease occurs a long time after exposure to lower doses of radiation as demonstrated in Japanese atomic bomb survivors. This review examines sources of radiation (atomic bombs, radiation accidents, radiological terrorism, cancer treatment, space exploration, radiosurgery for cardiac arrhythmia, and computed tomography) and the risk for developing cardiovascular disease. The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Studies are needed to define the extent that diagnostic and therapeutic radiation results in increased risk factors for cardiovascular disease, to understand the mechanisms involved, and to develop strategies to mitigate or treat radiation-induced cardiovascular disease.
Author List
Baker JE, Moulder JE, Hopewell JWAuthor
John E. Baker PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCardiovascular Diseases
Chernobyl Nuclear Accident
Environmental Exposure
Humans
Lipid Metabolism
Radiation Injuries
Radiation Injuries, Experimental
Radiation Tolerance
Radiography
Radiotherapy
Risk Factors
Space Flight
Terrorism
Whole-Body Irradiation
