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John E. Baker PhD

John E. Baker PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Cardiothoracic Surgery
Program: Research - Dr. Baker

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Microbiome Research

View Curriculum Vitae

Research Experience

  • Cardiovascular Agents
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Radiation Effects
  • Radiation Genetics
  • Radiation Injuries
  • Radiation Injuries, Experimental
  • Radiation Tolerance
  • Radiation, Ionizing
  • Radiation-Protective Agents
  • radiation effects
  • Microbiota

    • Clinical Expertise

  • Clinical Trial
  • Clinical Trials, Phase II as Topic
  • Drugs, Investigational

    • Leadership Positions

  • Chair, Institutional Animal Care and Use Committee

    • Publications (104)

  • Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats. (Raber J, Holden S, Kessler K, Glaeser B, McQuesten C, Chaudhari M, Stenzel F, Lenarczyk M, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen C, Willey JS, Bobe G, Minnier J, Baker JE) Front Physiol 2023;14:1316186 PMID: 38260101 PMCID: PMC10800373 SCOPUS ID: 2-s2.0-85182703793 01/23/2024    
  • Exposure to multiple ion beams, broadly representative of galactic cosmic rays, causes perivascular cardiac fibrosis in mature male rats. (Lenarczyk M, Kronenberg A, Mäder M, Komorowski R, Hopewell JW, Baker JE) PLoS One 2023;18(4):e0283877 PMID: 37099482 PMCID: PMC10132632 SCOPUS ID: 2-s2.0-85153985230 04/26/2023       1 Citation
  • Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics 2022, 10, 797. (Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE) Toxics 2023 Feb 16;11(2) PMID: 36851074 PMCID: PMC9959763 SCOPUS ID: 2-s2.0-85149176377 03/01/2023    
  • Myocardial Contractility Pattern Characterization in Radiation-Induced Cardiotoxicity Using Magnetic Resonance Imaging: A Pilot Study with ContractiX. (Ibrahim EH, Sosa A, Brown SA, An D, Klawikowski S, Baker J, Bergom C) Tomography 2022 Dec 22;9(1):36-49 PMID: 36648991 PMCID: PMC9844312 SCOPUS ID: 2-s2.0-85146484422 01/18/2023       1 Citation
  • T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. (Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE) Toxics 2022 Dec 18;10(12) PMID: 36548630 PMCID: PMC9783591 12/23/2022    
  • Change in out-of-hospital 12-lead ECG diagnostic classification following resuscitation from cardiac arrest. (Aufderheide TP, Engel TW 2nd, Saleh HO, Gutterman DD, Weston BW, Pepe PE, Baker JE, Labinski J, Debaty G, Tang L, Szabo A, Kalra R, Yannopoulos D, Colella MR) Resuscitation 2021 Dec;169:45-52 PMID: 34666124 SCOPUS ID: 2-s2.0-85118490179 10/20/2021    
  • Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats. (Raber J, Holden S, Sudhakar R, Hall R, Glaeser B, Lenarczyk M, Rockwell K, Nawarawong N, Sterrett J, Perez R, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen CM, Willey JS, Bobe G, Baker J) Front Physiol 2021;12:746509 PMID: 34646164 PMCID: PMC8503608 SCOPUS ID: 2-s2.0-85116920048 10/15/2021       13 Citations
  • Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit. (Borg AM, Baker JE) Synth Biol (Oxf) 2021;6(1):ysab023 PMID: 34522784 PMCID: PMC8434797 SCOPUS ID: 2-s2.0-85116474703 09/16/2021    
  • Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system. (Lenarczyk M, Laiakis EC, Mattson DL, Johnson BD, Kronenberg A, North PE, Komorowski R, Mäder M, Baker JE) FASEB Bioadv 2020 Dec;2(12):705-719 PMID: 33336158 PMCID: PMC7734425 SCOPUS ID: 2-s2.0-85101816410 12/19/2020       10 Citations
  • Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats. (Lenarczyk M, Kronenberg A, Mäder M, North PE, Komorowski R, Cheng Q, Little MP, Chiang IH, LaTessa C, Jardine J, Baker JE) Radiat Res 2019 Jul;192(1):63-74 PMID: 31095446 PMCID: PMC10654917 SCOPUS ID: 2-s2.0-85068362644 05/17/2019       8 Citations
  • Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. (Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME) Circ Res 2018 Oct 12;123(9):1091-1102 PMID: 30355158 PMCID: PMC6205737 SCOPUS ID: 2-s2.0-85055600525 10/26/2018       128 Citations
  • Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats. (Lam V, Su J, Hsu A, Gross GJ, Salzman NH, Baker JE) PLoS One 2016;11(8):e0160840 PMID: 27505423 PMCID: PMC4978455 SCOPUS ID: 2-s2.0-84983638440 08/10/2016       108 Citations
  • Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. (Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF) Am J Surg 2016 Oct;212(4):602-608 PMID: 27501776 SCOPUS ID: 2-s2.0-84991709365 08/10/2016       9 Citations
  • Recombinant erythropoietin mitigates reperfusion injury in neonatal rat cardiomyocytes by novel multiple signalling pathways (Allaudeen AP, Koka P, Pant T, Chandramohan Y, Sivanesan S, Baker JE, Dhanasekaran A) International Journal of Pharmacy and Pharmaceutical Sciences 2016;8(12):34-40 SCOPUS ID: 2-s2.0-85003875042 01/01/2016       1 Citation
  • Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation. (Lenarczyk M, Su J, Haworth ST, Komorowski R, Fish BL, Migrino RQ, Harmann L, Hopewell JW, Kronenberg A, Patel S, Moulder JE, Baker JE) Pharmacol Res Perspect 2015 Jun;3(3):e00145 PMID: 26171225 PMCID: PMC4492761 SCOPUS ID: 2-s2.0-84960387957 07/15/2015       20 Citations
  • Thrombopoietin receptor agonists protect human cardiac myocytes from injury by activation of cell survival pathways. (Baker JE, Su J, Koprowski S, Dhanasekaran A, Aufderheide TP, Gross GJ) J Pharmacol Exp Ther 2015 Mar;352(3):429-37 PMID: 25512369 SCOPUS ID: 2-s2.0-84921466193 12/17/2014       10 Citations
  • Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways. (Parvin A, Pranap R, Shalini U, Devendran A, Baker JE, Dhanasekaran A) PLoS One 2014;9(9):e107453 PMID: 25237819 PMCID: PMC4169563 SCOPUS ID: 2-s2.0-84907202527 09/23/2014       27 Citations
  • Cardioprotection from ischemia-reperfusion injury by near-infrared light in rats. (Quirk BJ, Sonowal P, Jazayeri MA, Baker JE, Whelan HT) Photomed Laser Surg 2014 Sep;32(9):505-11 PMID: 25093393 PMCID: PMC4142831 SCOPUS ID: 2-s2.0-84906490690 08/06/2014       7 Citations
  • Safety and blood sample volume and quality of a refined retro-orbital bleeding technique in rats using a lateral approach. (Sharma A, Fish BL, Moulder JE, Medhora M, Baker JE, Mader M, Cohen EP) Lab Anim (NY) 2014 Feb;43(2):63-6 PMID: 24451361 PMCID: PMC3989930 SCOPUS ID: 2-s2.0-84892989748 01/24/2014       56 Citations
  • Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs. (Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, Komorowski RA, Harmann L, Migrino RQ, Li XA, Hopewell JW, Moulder JE, Baker JE) Radiat Res 2013 Sep;180(3):247-58 PMID: 23919311 PMCID: PMC4042860 SCOPUS ID: 2-s2.0-84884273934 08/08/2013       40 Citations
  • Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus. (Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF) J Biol Chem 2013 Jan 04;288(1):737-46 PMID: 23148226 PMCID: PMC3537072 SCOPUS ID: 2-s2.0-84872066189 11/14/2012       72 Citations
  • Response. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Nov;26(11):4388-9 PMID: 23118151 11/03/2012    
  • Response (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB Journal November 2012;26(11):4388-4389 SCOPUS ID: 2-s2.0-84868288417 11/01/2012       2 Citations
  • Intestinal microbiota as novel biomarkers of prior radiation exposure. (Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE) Radiat Res 2012 May;177(5):573-83 PMID: 22439602 SCOPUS ID: 2-s2.0-84861374205 03/24/2012       63 Citations
  • Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID: 22247331 PMCID: PMC3316900 SCOPUS ID: 2-s2.0-84860909327 01/17/2012       245 Citations
  • Laminin 332 deposition is diminished in irradiated skin in an animal model of combined radiation and wound skin injury. (Jourdan MM, Lopez A, Olasz EB, Duncan NE, Demara M, Kittipongdaja W, Fish BL, Mäder M, Schock A, Morrow NV, Semenenko VA, Baker JE, Moulder JE, Lazarova Z) Radiat Res 2011 Nov;176(5):636-48 PMID: 21854211 PMCID: PMC3227557 SCOPUS ID: 2-s2.0-80155161949 08/23/2011       24 Citations
  • Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts. (Gross GJ, Baker JE, Moore J, Falck JR, Nithipatikom K) Cardiovasc Drugs Ther 2011 Dec;25(6):517-22 PMID: 21786213 PMCID: PMC3329256 SCOPUS ID: 2-s2.0-83055194622 07/26/2011       50 Citations
  • Radiation as a risk factor for cardiovascular disease. (Baker JE, Moulder JE, Hopewell JW) Antioxid Redox Signal 2011 Oct 01;15(7):1945-56 PMID: 21091078 PMCID: PMC3159113 SCOPUS ID: 2-s2.0-80052015096 11/26/2010       98 Citations
  • Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. (Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K) Am J Physiol Heart Circ Physiol 2010 Jun;298(6):H2201-7 PMID: 20400686 PMCID: PMC2886625 SCOPUS ID: 2-s2.0-77952663470 04/20/2010       29 Citations
  • Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. (Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE) J Inflamm (Lond) 2009 Dec 10;6:34 PMID: 20003243 PMCID: PMC2799407 SCOPUS ID: 2-s2.0-74549122003 12/17/2009       15 Citations
  • 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. (Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Allen Li X, Hopewell JW, Moulder JE) Int J Radiat Biol 2009 Dec;85(12):1089-100 PMID: 19995235 PMCID: PMC2792125 SCOPUS ID: 2-s2.0-72049116047 12/10/2009       95 Citations
  • Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. (Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF) Protein Sci 2009 Jul;18(7):1359-69 PMID: 19551879 PMCID: PMC2775206 SCOPUS ID: 2-s2.0-67650092745 06/25/2009       71 Citations
  • Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. (Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE) Cardiovasc Res 2009 Jul 15;83(2):325-34 PMID: 19380418 PMCID: PMC2701720 SCOPUS ID: 2-s2.0-67650236404 04/22/2009       20 Citations
  • Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. (Aggarwal NT, Pfister SL, Gauthier KM, Chawengsub Y, Baker JE, Campbell WB) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H678-88 PMID: 19112096 PMCID: PMC2660232 SCOPUS ID: 2-s2.0-64049085636 12/30/2008       11 Citations
  • Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. (Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE) J Mol Cell Cardiol 2008 Feb;44(2):345-51 PMID: 18083188 PMCID: PMC2322938 SCOPUS ID: 2-s2.0-39149132834 12/18/2007       10 Citations
  • Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) J Pharmacol Exp Ther 2008 Mar;324(3):1045-54 PMID: 18055876 PMCID: PMC2935083 SCOPUS ID: 2-s2.0-40849113307 12/07/2007       47 Citations
  • Mitochondrial big conductance KCa channel and cardioprotection in infant rabbit heart. (Shi Y, Jiang MT, Su J, Hutchins W, Konorev E, Baker JE) J Cardiovasc Pharmacol 2007 Nov;50(5):497-502 PMID: 18030058 SCOPUS ID: 2-s2.0-36349013696 11/22/2007       33 Citations
  • Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID: 18006466 PMCID: PMC2958050 SCOPUS ID: 2-s2.0-38849176235 11/17/2007       36 Citations
  • Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. (Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N) J Mol Cell Cardiol 2007 Oct;43(4):437-44 PMID: 17765919 PMCID: PMC2735077 SCOPUS ID: 2-s2.0-34548846129 09/04/2007       122 Citations
  • Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms. (Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ) J Cardiovasc Pharmacol 2007 Jun;49(6):337-45 PMID: 17577097 SCOPUS ID: 2-s2.0-34347212063 06/20/2007       43 Citations
  • SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) Basic Res Cardiol 2007 Jul;102(4):350-8 PMID: 17468933 PMCID: PMC3942648 SCOPUS ID: 2-s2.0-34250342563 05/01/2007       91 Citations
  • Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. (Cabigas BP, Su J, Hutchins W, Shi Y, Schaefer RB, Recinos RF, Nilakantan V, Kindwall E, Niezgoda JA, Baker JE) Cardiovasc Res 2006 Oct 01;72(1):143-51 PMID: 16930572 SCOPUS ID: 2-s2.0-33748146058 08/26/2006       68 Citations
  • Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants. (Nilakantan V, Zhou X, Hilton G, Shi Y, Baker JE, Khanna AK, Pieper GM) J Thorac Cardiovasc Surg 2006 Apr;131(4):898-906 PMID: 16580450 SCOPUS ID: 2-s2.0-33645389954 04/04/2006       17 Citations
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 SCOPUS ID: 2-s2.0-33645761913 02/16/2006       29 Citations
  • Erythropoietin mimics ischemic preconditioning. (Baker JE) Vascul Pharmacol 2005;42(5-6):233-41 PMID: 15922256 SCOPUS ID: 2-s2.0-19444372033 06/01/2005       66 Citations
  • Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID: 15808839 SCOPUS ID: 2-s2.0-20144388473 04/06/2005       31 Citations
  • Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID: 15611843 SCOPUS ID: 2-s2.0-25144473718 12/22/2004       98 Citations
  • Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID: 15388508 SCOPUS ID: 2-s2.0-11144258652 09/25/2004       37 Citations
  • Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. (Fitzpatrick CM, Shi Y, Hutchins WC, Su J, Gross GJ, Ostadal B, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H62-8 PMID: 15319200 SCOPUS ID: 2-s2.0-11144330066 08/21/2004       45 Citations
  • Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID: 15088102 SCOPUS ID: 2-s2.0-2342450561 04/17/2004       80 Citations
  • Oxidative stress and adaptation of the infant heart to hypoxia and ischemia. (Baker JE) Antioxid Redox Signal 2004 Apr;6(2):423-9 PMID: 15025944 SCOPUS ID: 2-s2.0-1542619247 03/18/2004       38 Citations
  • Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases, (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID: 12937165 SCOPUS ID: 2-s2.0-0242321893 08/26/2003       51 Citations
  • Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. (Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER) Circ Res 2003 May 16;92(9):992-1000 PMID: 12690037 SCOPUS ID: 2-s2.0-0037687982 04/12/2003       138 Citations
  • Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. (Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr) Circ Res 2002 Aug 23;91(4):300-6 PMID: 12193462 SCOPUS ID: 2-s2.0-0037163147 08/24/2002       91 Citations
  • Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 09;106(2):239-45 PMID: 12105165 SCOPUS ID: 2-s2.0-0037047058 07/10/2002       82 Citations
  • Delayed cardioprotection by isoflurane: role of K(ATP) channels. (Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE) Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H61-8 PMID: 12063275 SCOPUS ID: 2-s2.0-0036306453 06/14/2002       83 Citations
  • Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts. (Kong X, Tweddell JS, Gross GJ, Baker JE) J Mol Cell Cardiol 2001 May;33(5):1041-5 PMID: 11343425 SCOPUS ID: 2-s2.0-0034971965 05/10/2001       31 Citations
  • Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. (Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC) J Biol Chem 2001 May 25;276(21):17621-4 PMID: 11278264 SCOPUS ID: 2-s2.0-0035947583 03/30/2001       303 Citations
  • Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism. (Baker JE, Contney SJ, Singh R, Kalyanaraman B, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 2001 Feb;33(2):331-41 PMID: 11162137 SCOPUS ID: 2-s2.0-0034976745 02/13/2001       38 Citations
  • Increased mitochondrial K(ATP) channel activity during chronic myocardial hypoxia: is cardioprotection mediated by improved bioenergetics? (Eells JT, Henry MM, Gross GJ, Baker JE) Circ Res 2000 Nov 10;87(10):915-21 PMID: 11073888 SCOPUS ID: 2-s2.0-0034634296 11/14/2000       64 Citations
  • Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID: 11053770 SCOPUS ID: 2-s2.0-0034667740 10/29/2000       63 Citations
  • Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? (Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400 PMID: 10749737 SCOPUS ID: 2-s2.0-0034012881 04/06/2000       58 Citations
  • Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID: 10415535 SCOPUS ID: 2-s2.0-0032773216 07/23/1999       62 Citations
  • Preconditioning in immature rabbit hearts: role of KATP channels. (Baker JE, Holman P, Gross GJ) Circulation 1999 Mar 09;99(9):1249-54 PMID: 10069795 SCOPUS ID: 2-s2.0-0033537664 03/09/1999       65 Citations
  • Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID: 9889894 SCOPUS ID: 2-s2.0-0032444786 01/16/1999       11 Citations
  • Nitric oxide activates KATP channels during chronic myocardial hypoxia (Contney SJ, Baker JE, Gross GJ, Bosnjak ZJ) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-33749216999 03/20/1998    
  • Mitochondrial KATP channel activation in a rabbit model of chronic myocardial hypoxia (Eells JT, Henry MM, Gross GJ, Baker JE) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-25744453693 03/20/1998       1 Citation
  • Effect of exposure to hypoxia from birth on aldosterone in rabbits: Role of unesterified fatty acids (Raff H, Jankowski BM, Goodfriend TL, Baker JE, Papanek PE) American Journal of Physiology 1997;272(4 PART 2) SCOPUS ID: 2-s2.0-33745362312 12/01/1997       1 Citation
  • Myocardial protection of the hypoxic heart. (Baker JE, Olinger GN) J Thorac Cardiovasc Surg 1997 Jun;113(6):1123-4 PMID: 9202700 SCOPUS ID: 2-s2.0-0030986350 06/01/1997       7 Citations
  • Effect of exposure to hypoxia from birth on aldosterone in rabbits: role of unesterified fatty acids. (Raff H, Jankowski BM, Goodfriend TL, Baker JE, Papanek PE) Am J Physiol 1997 Apr;272(4 Pt 2):R1084-7 PMID: 9140005 SCOPUS ID: 2-s2.0-0030991909 04/01/1997       8 Citations
  • Increased tolerance of the chronically hypoxic immature heart to ischemia. Contribution of the KATP channel. (Baker JE, Curry BD, Olinger GN, Gross GJ) Circulation 1997 Mar 04;95(5):1278-85 PMID: 9054860 03/04/1997    
  • KATP channel activation in a rabbit model of chronic myocardial hypoxia. (Baker JE, Contney SJ, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 1997 Feb;29(2):845-8 PMID: 9140841 SCOPUS ID: 2-s2.0-0031064086 02/01/1997       29 Citations
  • Spin label oximetry to assess extracellular oxygen during myocardial ischemia. (Baker JE, Froncisz W, Joseph J, Kalyanaraman B) Free Radic Biol Med 1997;22(1-2):109-15 PMID: 8958135 SCOPUS ID: 2-s2.0-0029911540 01/01/1997       22 Citations
  • Increased tolerance of the chronically hypoxic immature heart to ischemia: Contribution of the K(ATP) channel (Baker JE, Curry BD, Olinger GN, Gross GJ) Circulation 1997;95(5):1278-1285 SCOPUS ID: 2-s2.0-0031037762 01/01/1997       72 Citations
  • Exposure to hypoxia hrom birth increases free fatty acids and inhibits aedosterone production in rabbits (Papanek PE, Jankowski BM, Baker JE, Goodfriend TL, Raff H) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33749270832 12/01/1996    
  • Impact of low-power red laser light on restenosis following balloon angioplasty (Kipshidze N, Horn JB, Sahota H, Zulich A, Keane S, Baker JE, Komorowski R, Nikolaychik V, Keelan MH) Proceedings of SPIE - The International Society for Optical Engineering 1996;2922:414-421 SCOPUS ID: 2-s2.0-0030365660 12/01/1996    
  • Postnatal developmental profiles of antioxidant enzymes in heart. (Maulik N, Baker JE, Engelman RM, Das DK) Ann N Y Acad Sci 1996 Sep 30;793:439-48 PMID: 8906189 SCOPUS ID: 2-s2.0-0029830258 09/30/1996       6 Citations
  • S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) J Pharmacol Exp Ther 1995 Jul;274(1):200-6 PMID: 7616400 SCOPUS ID: 2-s2.0-0029075141 07/01/1995       80 Citations
  • Direct effects of halothane and isoflurane in infant rabbit hearts with right ventricular hypertrophy secondary to chronic hypoxemia. (Palmisano BW, Mehner RW, Baker JE, Stowe DF, Bosnjak ZJ, Kampine JP) Anesth Analg 1995 Jun;80(6):1122-8 PMID: 7762838 SCOPUS ID: 2-s2.0-0029008026 06/01/1995       10 Citations
  • Tolerance of the developing heart to ischemia: impact of hypoxemia from birth. (Baker EJ, Boerboom LE, Olinger GN, Baker JE) Am J Physiol 1995 Mar;268(3 Pt 2):H1165-73 PMID: 7900870 SCOPUS ID: 2-s2.0-0028931270 03/01/1995       81 Citations
  • Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) Free Radic Biol Med 1995 Feb;18(2):169-77 PMID: 7744299 SCOPUS ID: 2-s2.0-0028796439 02/01/1995       35 Citations
  • Calcium and cardioplegic protection of the ischemic immature heart: impact of hypoxemia from birth. (Baker EJ, Baker JE) Ann Thorac Surg 1994 Oct;58(4):1123-30 PMID: 7944763 SCOPUS ID: 2-s2.0-0028138602 10/01/1994       10 Citations
  • Lack of protection of PBN in isolated heart during ischemia and reperfusion: implications for radical scavenging mechanism. (Baker JE, Konorev EA, Tse SY, Joseph J, Kalyanaraman B) Free Radic Res 1994 Mar;20(3):145-63 PMID: 8019639 SCOPUS ID: 2-s2.0-0028215452 03/01/1994       10 Citations
  • Radical generation and detection in myocardial injury (Kalyanaraman B, Konorev EA, Joseph J, Baker JE) New Comprehensive Biochemistry 1 January 1994;28(C):333-359 SCOPUS ID: 2-s2.0-77956861027 01/01/1994       10 Citations
  • Protection of the ischemic immature heart--effect of perfusate reinfusion and composition. (Baker JE, Olinger GN, Boerboom LE) Thorac Cardiovasc Surg 1993 Oct;41(5):274-9 PMID: 8303694 SCOPUS ID: 2-s2.0-0027431933 10/01/1993       3 Citations
  • Recovery of hypoxic neonatal hearts after cardioplegic arrest. (Baker JE) Cardiovasc Res 1993 Jun;27(6):1135-6 PMID: 8221776 SCOPUS ID: 2-s2.0-85047678754 06/01/1993    
  • Age and protection of the ischemic myocardium: is alkaline cardioplegia appropriate? (Baker JE, Boerboom LE, Olinger GN) Ann Thorac Surg 1993 Mar;55(3):747-55 PMID: 8452442 SCOPUS ID: 2-s2.0-0027414545 03/01/1993       21 Citations
  • Vasodilatory and toxic effects of spin traps on aerobic cardiac function. (Konorev EA, Baker JE, Joseph J, Kalyanaraman B) Free Radic Biol Med 1993 Feb;14(2):127-37 PMID: 8425719 SCOPUS ID: 2-s2.0-0027473299 02/01/1993       66 Citations
  • Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries. (Konorev EA, Struck AT, Baker JE, Ramanujam S, Thomas JP, Radi R, Kalyanaraman B) Free Radic Res Commun 1993;19(6):397-407 PMID: 8168729 SCOPUS ID: 2-s2.0-0027759676 01/01/1993       12 Citations
  • Calcium content of St. Thomas' II cardioplegic solution damages ischemic immature myocardium. (Baker EJ 5th, Olinger GN, Baker JE) Ann Thorac Surg 1991 Oct;52(4):993-9 PMID: 1929665 SCOPUS ID: 2-s2.0-0025945370 10/11/1991       29 Citations
  • Cardioplegia-induced damage to ischemic immature myocardium is independent of oxygen availability. (Baker JE, Boerboom LE, Olinger GN) Ann Thorac Surg 1990 Dec;50(6):934-9 PMID: 2241386 SCOPUS ID: 2-s2.0-0025570174 12/01/1990       15 Citations
  • On the detection of paramagnetic species in the adriamycin-perfused rat heart: a reappraisal. (Kalyanaraman B, Baker JE) Biochem Biophys Res Commun 1990 May 31;169(1):30-8 PMID: 2161659 SCOPUS ID: 2-s2.0-0025333513 05/31/1990       2 Citations
  • Is protection of ischemic neonatal myocardium by cardioplegia species dependent? (Baker JE, Boerboom LE, Olinger GN) J Thorac Cardiovasc Surg 1990 Feb;99(2):280-7 PMID: 2299865 SCOPUS ID: 2-s2.0-0025312107 02/01/1990       30 Citations
  • Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. (Baker JE, Kalyanaraman B) FEBS Lett 1989 Feb 27;244(2):311-4 PMID: 2537756 SCOPUS ID: 2-s2.0-0024561513 02/27/1989       43 Citations
  • Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID: 2905005 SCOPUS ID: 2-s2.0-0024269976 12/01/1988       11 Citations
  • Age-related changes in the ability of hypothermia and cardioplegia to protect ischemic rabbit myocardium. (Baker JE, Boerboom LE, Olinger GN) J Thorac Cardiovasc Surg 1988 Nov;96(5):717-24 PMID: 3184966 SCOPUS ID: 2-s2.0-0023701072 11/01/1988       73 Citations
  • Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy. (Baker JE, Felix CC, Olinger GN, Kalyanaraman B) Proc Natl Acad Sci U S A 1988 Apr;85(8):2786-9 PMID: 2833754 PMCID: PMC280084 SCOPUS ID: 2-s2.0-0007472414 04/01/1988       197 Citations
  • Differing potencies and dose-response characteristics in the ability of slow-calcium-channel blockers to reduce enzyme leakage in the calcium paradox. (Baker JE, Hearse DJ) Adv Myocardiol 1985;6:637-46 PMID: 2581302 SCOPUS ID: 2-s2.0-0021941525 01/01/1985       2 Citations
  • Calcium delivery and time: factors affecting the progression of cellular damage during the calcium paradox in the rat heart. (Baker JE, Kemmenoe BH, Hearse DJ, Bullock GR) Cardiovasc Res 1984 Jun;18(6):361-70 PMID: 6331667 SCOPUS ID: 2-s2.0-85047678113 06/01/1984       11 Citations
  • The temperature-sensitivity of slow channel calcium blockers in relation to their effect upon the calcium paradox. (Baker JE, Hearse DJ) Eur Heart J 1983 Dec;4 Suppl H:97-103 PMID: 6662136 SCOPUS ID: 2-s2.0-0021014317 12/01/1983       4 Citations
  • Slow calcium channel blockers and the calcium paradox: comparative studies in the rat with seven drugs. (Baker JE, Hearse DJ) J Mol Cell Cardiol 1983 Jul;15(7):475-85 PMID: 6312058 SCOPUS ID: 2-s2.0-0020609650 07/01/1983       24 Citations
  • The temperature dependence of the calcium paradox: enzymatic, functional and morphological correlates of cellular injury. (Baker JE, Bullock GR, Hearse DJ) J Mol Cell Cardiol 1983 Jun;15(6):393-411 PMID: 6876188 SCOPUS ID: 2-s2.0-0020512616 06/01/1983       35 Citations
  • Verapamil and the calcium paradox: a reaffirmation. (Hearse DJ, Baker JE) J Mol Cell Cardiol 1981 Dec;13(12):1087-90 PMID: 7328668 SCOPUS ID: 2-s2.0-0019866916 12/01/1981       5 Citations
  • Verapamil and the calcium paradox. (Hearse DJ, Baker JE, Humphrey SM) J Mol Cell Cardiol 1980 Jul;12(7):733-9 PMID: 7411649 SCOPUS ID: 2-s2.0-0019307110 07/01/1980       43 Citations
    • Last update: 03/07/2024