Faculty Collaboration Database

Pigeons breeders' disease. I. Serum immunoglobulin concentrations; IgG, IgM, IgA and IgE antibodies against pigeon serum. Am J Med 1976 Jan;60(1):144-51

Date

01/01/1976

Pubmed ID

943140

DOI

10.1016/0002-9343(76)90543-x

Scopus ID

2-s2.0-0017106155 (requires institutional sign-in at Scopus site)   27 Citations

Abstract

The clinical course of a patient with severe acute and chronic hypersensitivity pneumonitis of the pigeon breeders' disease (PBD) type was evaluated. A significant remission of symptomatic, roentgenographic and pulmonary function abnormalities occurred after cessation of exposure to antigen. Immunoglobulin G (IgG), A (IgA) and M (IgM) antibody activity against pigeon serum was demonstrated in the patient's serum by a solid phase radioimmunoassay (RIA) technic. The levels of these antibodies fell subsequent to elimination of antigen inhalation. The RIA technic was used to demonstrate IgG, IgA and IgM antibody activity in single serum samples of four other patients with PBD, and this technic may have diagnostic value. Although no immunoglobulin E (IgE) antibody was demonstrable by RIA, a heat-liable, reaginic antibody was also detectable in the serum of the primary case. In addition, Arthus type cutaneous reactivity was passively transferred to the skin of a volunteer subject using heated serum from a patient with PBD.

Author List

Patterson R, Schatz M, Fink JN, DeSwarte RS, Roberts M, Cugell D

MESH terms used to index this publication - Major topics in bold

Aged
Animals
Antibody Formation
Antigens
Columbidae
Farmer's Lung
Humans
Immunization, Passive
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Male