Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. Proc Natl Acad Sci U S A 1996 Jun 25;93(13):6275-9
Date
06/25/1996Pubmed ID
8692805Pubmed Central ID
PMC39012DOI
10.1073/pnas.93.13.6275Scopus ID
2-s2.0-0029957831 (requires institutional sign-in at Scopus site) 83 CitationsAbstract
MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates. Biochemical evidence demonstrates that these proteins integrate calcium and PKC-dependent signals to regulate actin structure at the membrane. We report here that deletion of the MacMARCKS gene prevents cranial neural tube closure in the developing brain, resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal transduction pathway in the folding of the anterior neural plate during the early phases of brain formation, and supports the hypothesis that actin-based motility directs cranial neural tube closure.
Author List
Chen J, Chang S, Duncan SA, Okano HJ, Fishell G, Aderem AMESH terms used to index this publication - Major topics in bold
AnencephalyAnimals
Base Sequence
Brain
Calmodulin-Binding Proteins
Cell Line
Chimera
DNA Primers
Embryonic and Fetal Development
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Mice
Mice, Inbred C57BL
Microfilament Proteins
Molecular Sequence Data
Neural Tube Defects
Protein Kinase C
Proteins
Signal Transduction
