Transformation of cardiac endothelium into cushion mesenchyme is dependent on ES/130: temporal, spatial, and functional studies in the early chick embryo. Cell Mol Biol Res 1995;41(4):263-77
Date
01/01/1995Pubmed ID
8775984Scopus ID
2-s2.0-0029591364 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
ES/130 is a novel 130-kDa protein that has been linked previously to the transformation of endocardial endothelium into cushion mesenchyme. In the present study we report the localization of protein and mRNA for ES/130 in stages 7-plus through 20 chick embryos and present functional data related to a potential mechanism for ES/130. The temporal and spatial regulation of ES/130 expression suggests that this epithelial-to-mesenchymal transformation is a result of homogenetic induction. Functional studies indicate that myocardially derived ES/130 elicits expression of this protein by target AV endothelial cells, which is linked to a signal transduction cascade. The localization of ES/130 to other sites of inductive interactions (e.g., limb bud ectoderm, gut, and notochord) implies that this protein may have a more widespread importance to embryogenesis beyond its involvement in cardiac cushion tissue formation.
Author List
Krug EL, Rezaee M, Isokawa K, Turner DK, Litke LL, Wunsch AM, Bain JL, Riley DA, Capehart AA, Markwald RRMESH terms used to index this publication - Major topics in bold
AnimalsAvian Proteins
Base Sequence
Cells, Cultured
Chick Embryo
Down-Regulation
Embryonic Induction
Endothelium
Extracellular Matrix Proteins
Gene Expression Regulation, Developmental
Heart
Immunohistochemistry
In Situ Hybridization
Mesoderm
Molecular Sequence Data
Morphogenesis
RNA, Messenger
Signal Transduction
Time Factors
