Faculty Collaboration Database

STAT signaling is active during early mammalian development. Dev Dyn 1997 Feb;208(2):190-8

Date

02/01/1997

Pubmed ID

9022056

DOI

10.1002/(SICI)1097-0177(199702)208:2<190::AID-AJA6>3.0.CO;2-D

Scopus ID

2-s2.0-0031024108 (requires institutional sign-in at Scopus site)   86 Citations

Abstract

Cytokine activation of gene expression can be mediated through signal transducer and activator of transcription (STAT) signaling pathways resulting in expression of target genes. Because many cytokines have important regulatory roles during early development, we wanted to ascertain whether STAT signaling was also active at this time and could therefore have important roles in mediating developmental processes. We have found that Stat1 and Stat3 mRNAs are present in both maternal and extraembryonic tissues during early postimplantation stages of murine development. Furthermore, analyses of STAT activity in E4.5-E9.5 decidual swellings by electrophoretic mobility shift assay demonstrated that Stat3 protein was active during this early developmental period. The identification of activated Stat3 demonstrates that STAT signaling functions during early postimplantation development in the mouse are likely to be important during early embryogenesis.

Author List

Duncan SA, Zhong Z, Wen Z, Darnell JE Jr

MESH terms used to index this publication - Major topics in bold

Animals
DNA-Binding Proteins
Embryonic and Fetal Development
Female
Gene Expression Regulation, Developmental
Mice
Pregnancy
RNA, Messenger
STAT1 Transcription Factor
STAT3 Transcription Factor
Signal Transduction
Trans-Activators