Faculty Collaboration Database

Comparative effects of a new calcium antagonist, FR 7534, nitroglycerin, and dipyridamole on regional myocardial blood flow and cardiac contractility during partial coronary artery occlusion in the dog. J Cardiovasc Pharmacol 1980;2(6):797-813

Date

11/01/1980

Pubmed ID

6160329

DOI

10.1097/00005344-198011000-00009

Scopus ID

2-s2.0-0018948623 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

The present study was designed to determine the effects of three different types of coronary vasodilators--FR 7534 (a new calcium antagonist), nitroglycerin, and dipyridamole--on the transmural blood flow and contractile function in the normal and ischemic myocardium of anesthetized dogs. Radioactive microspheres (15 muc) and Walton-Brodie strain gauge arches were used to measure tissue blood flow and contractile force, respectively. During 5 min intravenous infusions of nitroglycerin (5 microgram/kg/min) or dipyridamole (50 microgram/kg/min), which produced approximately 20% reductions in mean aortic pressure, blood flow and contractile force in ischemic myocardium decreased significantly. Under similar conditions, FR 7534 (10 microgram/kg/min) produced a significant decrease in ischemic contractile force, but tissue blood flow to the ischemic area did not change. In contrast, when mean aortic pressure was controlled by administration of methoxamine, nitroglycerin produced significant increases in ischemic blood flow (42%) and contractile force (47%), whereas dipyridamole produced significant decreases (41 and 32%, respectively). On the other hand, FR 7534 plus methoxamine produced a significant increase in ischemic blood flow (70%); however, ischemic contractile force did not change. These results demonstrate FR 7534 to affect the oxygen supply-demand balance in ischemic myocardium favorably by maintaining blood flow and depressing contractility during hypotension or by increasing flow during controlled systemic pressure.

Author List

Gross GJ, Warltier DC, Jolly SR, Hardman HF

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Calcium
Coronary Circulation
Coronary Disease
Dipyridamole
Dogs
Female
Male
Methoxamine
Myocardial Contraction
Nifedipine
Nitroglycerin
Pyridines
Regional Blood Flow
Vasodilator Agents