Medical College of Wisconsin
CTSIResearch InformaticsREDCap

Myocardial distribution of coronary blood flow in the isolated supported heart preparation. Cardiovasc Res 1975 Sep;9(5):634-9

Date

09/01/1975

Pubmed ID

1201572

DOI

10.1093/cvr/9.5.634

Scopus ID

2-s2.0-0016760079 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

The regional distribution of myocardial blood flow was studied by use of radioactive microspheres (15 micro-meters [mum]) under control conditions and during an intracoronary infusion of norepinephrine (2mug/min). In control experiments endocardial blood flow was generally greater than epicardial flow; during administration of norepinephrine the endocardium received significantly less blood flow. It is proposed that normally the endocardium is well perfused, but under conditions of stress, eg, norepinephrine infusion in the presence of a constant coronary blood flow, decreased endocardial blood flow results.

Author List

Warltier DC, Hardman HF, Laddu AR, Somani P, Gross GJ

Author

David C. Warltier PhD Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cesium Radioisotopes
Coronary Circulation
Coronary Vessels
Depression, Chemical
Dogs
Endocardium
Female
In Vitro Techniques
Male
Microspheres
Norepinephrine
Perfusion
Stress, Physiological
Strontium Radioisotopes