Liquid ventilation. Clin Perinatol 1998 Sep;25(3):711-22
Date
10/21/1998Pubmed ID
9779343DOI
10.1016/s0095-5108(18)30107-6Scopus ID
2-s2.0-0031688253 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
For decades, the fluid-filled lung has been a valuable research model for understanding normal and abnormal pulmonary physiology. It has lagged behind, however, as a useful therapeutic tool. Recently, the potential applications of perflubron's physicochemical and biologic properties have been realized. In animal models of several types of hypoxic respiratory failure, perflubron's efficacy in improving gas exchange and compliance has been demonstrated. Preliminary clinical studies of PLV in neonates who have RDS and CDH, and in children and adults who have ARDS have shown promise. Pivotal prospective, controlled studies have yet to be completed.
Author List
Day SE, Gedeit RGAuthor
Rainer G. Gedeit MD Associate Chief Medical Officer in the Children's Administration department at Children's WisconsinMESH terms used to index this publication - Major topics in bold
AdultChild
Fluorocarbons
Humans
Hydrocarbons, Brominated
Infant, Newborn
Lung Compliance
Pulmonary Gas Exchange
Research Design
Respiration, Artificial
Respiratory Insufficiency
