Medical College of Wisconsin
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Fulminant progression of demyelinating disease after valproate-induced encephalopathy. Neurology 1998 Jul;51(1):292-5

Date

07/23/1998

Pubmed ID

9674826

DOI

10.1212/wnl.51.1.292

Scopus ID

2-s2.0-0031868351 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

We report the clinical, radiologic, and pathologic features of a patient who had fulminant demyelinating disease and who experienced acute progression of his disease after an episode of valproate-induced hyperammonemic encephalopathy. The role hyperammonemia played in the progression of the demyelination is uncertain. This case raises concern of a possible risk with the use of valproic acid in the subset of patients with fulminant demyelinating disease.

Author List

Blindauer KA, Harrington G, Morris GL 3rd, Ho KC

Author

Karen A. Blindauer MD Chief, Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Anticonvulsants
Brain Stem
Cerebral Cortex
Contraindications
Demyelinating Diseases
Encephalitis
Humans
Male
Valproic Acid