Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide. Curr Hypertens Rep 2010 Apr;12(2):86-92
Date
04/29/2010Pubmed ID
20424940Pubmed Central ID
PMC3722865DOI
10.1007/s11906-010-0094-6Scopus ID
2-s2.0-77953538736 (requires institutional sign-in at Scopus site) 58 CitationsAbstract
The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriuresis curve. The development of renal medullary oxidative stress causes dysfunction of the pressure-natriuresis mechanism and contributes to the development of hypertension in numerous disease models. The purpose of this review is to point out the known mechanisms within the renal medulla through which reactive oxygen and nitrogen species modulate the pressure-natriuresis response and to update the reader on recent advances in this field.
Author List
O'Connor PM, Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood PressureDiuresis
Endothelins
Endothelium, Vascular
Endothelium-Dependent Relaxing Factors
Humans
Hydrogen Peroxide
Kidney Medulla
Natriuresis
Nitric Oxide
Nitric Oxide Synthase
Oxidative Stress
Reactive Oxygen Species
Signal Transduction
Sodium, Dietary
Superoxides
Water-Electrolyte Balance
