Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats. Mol Cell Biochem 2001 Oct;226(1-2):83-8
Date
01/05/2002Pubmed ID
11768242DOI
10.1023/a:1012789819926Scopus ID
2-s2.0-0035197552 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Recently, the calcium-calmodulin-dependent calcineurin pathway has been defined as a central pathway for the induction of cardiac hypertrophy. The purpose of this study was to determine if cardiac hypertrophy in animals chronically treated with angiotensin II (AngII), could be prevented by blocking this pathway with cyclosporin A (CsA). Female Wistar rats were treated with AngII by subcutaneous infusion and injected twice a day with CsA (25 mg/kg) for 7 days. In the AngII treated group there was a 30% increase in the heart/body weight ratio (p < 0.05 vs. control). The increase in heart weight was blocked with CsA. Substantial increases in ANF and betaMHC gene expression were detected in the AngII treated animals, which were either attenuated or blocked with CsA treatment. Thus, this study demonstrates that CsA does prevent the development of cardiac hypertrophy in AngII treated rats, suggesting that the calcium-calmodulin-dependent calcineurin pathway is associated with angiotensin II induced hypertrophy in vivo.
Author List
Goldspink PH, McKinney RD, Kimball VA, Geenen DL, Buttrick PMMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Blotting, Northern
Body Weight
Calcineurin
Calcium
Cardiomegaly
Cyclosporine
Dose-Response Relationship, Drug
Enzyme Inhibitors
Female
Hypertrophy
Myocardium
Organ Size
RNA
Rats
Rats, Wistar
Signal Transduction
Up-Regulation
