Central nervous system involvement at the time of presentation in acute promyelocytic leukemia. Pediatr Blood Cancer 2010 Apr;54(4):603-5
Date
12/10/2009Pubmed ID
19998465DOI
10.1002/pbc.22348Scopus ID
2-s2.0-77649164841 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Central nervous system (CNS) involvement is rarely observed in acute promyelocytic leukemia (APML). Most cases of CNS involvement occur at relapse rather than at presentation. Because of the extremely low incidence of CNS disease, diagnostic lumbar puncture is not routinely required and prophylactic intrathecal chemotherapy is not routinely administered. Here, we describe a teenage patient with newly diagnosed APML, chloromas, and symptomatic CNS involvement confirmed by MRI and cerebrospinal fluid (CSF) findings.
Author List
Collins C, Knoderer HMESH terms used to index this publication - Major topics in bold
AdolescentAntineoplastic Combined Chemotherapy Protocols
Central Nervous System Neoplasms
Combined Modality Therapy
Cytarabine
Daunorubicin
Female
Humans
Leukemia, Promyelocytic, Acute
Leukemic Infiltration
Mercaptopurine
Methotrexate
Oncogene Proteins, Fusion
Radiotherapy
Sarcoma, Myeloid
Tretinoin
