Faculty Collaboration Database

Biodistribution of 99Tcm-labelled 5-thio-D-glucose. Nucl Med Commun 1999 Nov;20(11):1055-8

Date

11/26/1999

Pubmed ID

10572916

DOI

10.1097/00006231-199911000-00011

Scopus ID

2-s2.0-0032586058 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

We studied the biodistribution and tumour localization of 99Tcm-labelled-5-thio-D-glucose (99Tcm-TG). 5-Thio-D-glucose was labelled with 99Tcm by direct stannous ion reduction. The biodistribution of 99Tcm-TG was investigated in normal rabbits and in mice bearing experimental tumours. In rabbits, the plasma and clearance of 99Tcm-TG was 14.5 +/- 2.0 and 11.3 +/- 3.0 ml.min-1 respectively. Urinary excretion at 1 h was 53 +/- 5%. 99Tcm-TG was injected intravenously in mice bearing MC26 colon carcinoma and tissue samples were analysed by gamma scintillation counting at various times. Uptake of 99Tcm-TG in tumour at 1 and 3 h was 1.6 +/- 0.3% and 1.2 +/- 0.3%; the tumour to muscle ratios were 2.7:1 and 4:1 respectively. The autoradiographic biodistribution of 99Tcm-TG in MX-1 human breast xenografted nude mice showed more persistent tumour uptake of 99Tcm-TG than 14C-2-deoxyglucose (14C-DG). 99Tcm-TG accumulated in the centre of the tumours; 14C-DG was decreased in this central region probably because of zones of infarction on necrosis. The discordance between the tumour uptake of 99Tcm-TG and 14C-DG indicates that 99Tcm-TG does not act like a glucose analog, suggesting 99Tcm-TG avidity for zones of infarction or necrosis. The further study of 99Tcm-TG in tumours and ischaemic injury is warranted.

Author List

Ozker K, Collier BD, Lindner DJ, Kabasakal L, Liu Y, Krasnow AZ, Hellman RS, Edwards SD, Bourque CR, Crane PD

MESH terms used to index this publication - Major topics in bold

Animals
Antimetabolites
Autoradiography
Breast Neoplasms
Deoxyglucose
Glucose
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental
Organotechnetium Compounds
Rabbits
Radionuclide Imaging
Radiopharmaceuticals
Tissue Distribution
Transplantation, Heterologous