The interaction of thrombin with blood platelets. Platelets 2005 Nov;16(7):373-85
Date
10/21/2005Pubmed ID
16236598DOI
10.1080/09537100500123568Scopus ID
2-s2.0-27644452637 (requires institutional sign-in at Scopus site) 52 CitationsAbstract
Thrombin is a potent agonist of platelets. In the current article, the research on the interaction of thrombin with blood platelets is reviewed starting with the first studies demonstrating the direct action of thrombin on platelets and ending with an analysis of the importance of the protease-activated receptors (PARs) and the GpIb complex. The antithrombin activity of platelets is discussed in terms of the binding of thrombin to receptor(s) on the platelet surface. Evaluation of the PAR receptors and the GpIb supports a model where thrombin binds to the GpIb receptor prior to the proteolysis of the PAR receptor(s). Thus, the maximal hemostatic response requires both PAR receptors and the GpIb receptors.
Author List
Lundblad RL, White GC 2ndAuthor
Gilbert C. White MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Platelets
Fibrin
Fibrinogen
GTP-Binding Proteins
Humans
Membrane Proteins
Platelet Activation
Platelet Aggregation
Platelet Glycoprotein GPIb-IX Complex
Protein Binding
Receptors, Proteinase-Activated
Thrombin
