Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 2007 May;12(5):535-42
Date
05/25/2007Pubmed ID
17522241DOI
10.1634/theoncologist.12-5-535Scopus ID
2-s2.0-34548452775 (requires institutional sign-in at Scopus site) 167 CitationsAbstract
A growing body of literature is demonstrating that Notch signaling is a more complex process than originally thought. Contradictory findings of notch-1 acting as an oncogene or a tumor suppressor revealed that its role is very specific to the cellular context. In this review we focus on the tumor suppressor role of Notch-1 signaling in neuroendocrine tumors (NETs) such as carcinoid and medullary thyroid cancers. NETs secrete various bioactive hormones that can cause debilitating symptoms. Surgery is the only potential curative treatment for the patients with NETs. Notch-1 signaling is absent in these tumors and activation of Notch-1 significantly reduces tumor growth in vitro. Therefore, identification of compound(s) that activate the Notch-1 pathway in NETs could be a potential strategy to treat patients with NETs.
Author List
Kunnimalaiyaan M, Chen HMESH terms used to index this publication - Major topics in bold
AnimalsCarcinoid Tumor
Carcinoma, Medullary
Carcinoma, Small Cell
Humans
Lung Neoplasms
Neuroendocrine Tumors
Receptor, Notch1
Signal Transduction
Tumor Suppressor Proteins
