Faculty Collaboration Database

Neuronal experience modifies synaptic long-term facilitation. Can J Physiol Pharmacol 1986 Jul;64(7):1052-4

Date

07/01/1986

Pubmed ID

3021306

DOI

10.1139/y86-180

Scopus ID

2-s2.0-0022462513 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

In a crayfish phasic neuromuscular junction, we have demonstrated low-frequency depression (LFD), high-frequency depression (HFD), and long-term facilitation (LTF) in response to different regimens of stimulation. Chronic stimulation of the phasic axon supplying the closer muscle of the claw in Procambarus clarkii resulted in diminished expression of HFD and LTF. Conversely, when impulse production in the phasic motoneuron was reduced by claw immobilization, both HFD and LTF were enhanced. LFD was insensitive to these manipulations. These results provide further evidence for long-term adaptation of the phasic neuromuscular junction to ongoing levels of impulse activity and illustrate the importance of a neuron's past history for synaptic plasticity. The ability of the neuron to adjust its short-term plasticity in response to altered experience constitutes an adaptive response that could be of general significance.

Author List

Pahapill PA, Lnenicka GA, Atwood HL

Author

Peter A. Pahapill PhD, MS, MD Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adaptation, Physiological
Animals
Astacoidea
Electric Stimulation
Evoked Potentials
In Vitro Techniques
Neuromuscular Junction
Neuronal Plasticity
Synaptic Transmission