Faculty Collaboration Database

MRI validated echocardiographic technique to measure total cardiac volume: a tool for donor-recipient size matching in pediatric heart transplantation. Pediatr Transplant 2013 May;17(3):300-6

Date

03/16/2013

Pubmed ID

23489637

Pubmed Central ID

PMC4662949

DOI

10.1111/petr.12063

Scopus ID

2-s2.0-84876712340 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

Our aim is to develop and validate an accurate method for estimating TCV using standard echocardiographic imaging that can be easily employed to aid in donor-recipient size matching in pediatric heart transplantation. Thirty patients who underwent Echo and cardiac magnetic resonance imaging (cMRI) were identified. TCV was measured on cMRI. TCV was determined echocardiographically by two methods: a volume measurement using the modified Simpson's method on a four-chamber view of the heart; and a calculated volume measurement which assumed a true-elliptical shape of the heart. These two methods where compared with the value obtained by cMRI using the concordance correlation coefficient (CCC). TCV by method 1 correlated well with cMRI (CCC = 0.98%, CI = 0.97, 0.99). TCV by method 2 had a CCC = 0.90 (CI = 0.9464, 0.9716) when compared to cMRI. Left ventricular end-diastolic volume (LVEDV) also correlated as a predictor of TCV in patients with structurally normal hearts and could be described by the equation: TCV = 6.6 (LVEDV) + 12 (R(2)  = 0.97). Echocardiographic assessment of TCV for recipients and their potential donors is a simple process and can be prospectively applied as part of donor evaluation.

Author List

Camarda J, Saudek D, Tweddell J, Mitchell M, Woods R, Otto M, Simpson P, Stendahl G, Berger S, Zangwill S

Authors

Michael Edward Mitchell MD Chief, Professor in the Surgery department at Medical College of Wisconsin
David Saudek MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Cardiac Volume
Child
Child, Preschool
Diastole
Echocardiography
Female
Heart Defects, Congenital
Heart Transplantation
Heart Ventricles
Humans
Infant
Magnetic Resonance Imaging
Male
Myocardium
Organ Size
Reproducibility of Results
Tissue and Organ Procurement
Treatment Outcome
Young Adult