Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol 2013 Apr;161(1):3-14
Date
02/07/2013Pubmed ID
23384054Pubmed Central ID
PMC3895911DOI
10.1111/bjh.12235Scopus ID
2-s2.0-84875054296 (requires institutional sign-in at Scopus site) 156 CitationsAbstract
Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.
Author List
Peterson JA, McFarland JG, Curtis BR, Aster RHAuthor
Brian Curtis PhD Director in the Platelet & Neutrophil Immunology Laboratory department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
Antigens, Human PlateletBiomarkers
Female
Humans
Infant, Newborn
Perinatal Care
Platelet Transfusion
Pregnancy
Prenatal Care
Thrombocytopenia, Neonatal Alloimmune
