Medical College of Wisconsin
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Learning from failure: congestive heart failure in the postgenomic age. J Clin Invest 2005 Mar;115(3):495-9

Date

03/15/2005

Pubmed ID

15765130

Pubmed Central ID

PMC1052014

DOI

10.1172/JCI24477

Scopus ID

2-s2.0-14644404257 (requires institutional sign-in at Scopus site)   59 Citations

Abstract

The prognosis of heart failure is worse than that of most cancers, but new therapeutic interventions using stem and other cell-based therapies are succeeding in the fight against it, and old drugs, with new twists, are making a comeback. Genetically engineered animal models are driving insights into the molecular mechanisms that cause hearts to fail, accelerating drug discoveries, and inspiring cell-based therapeutic interventions for both acquired and inheritable cardiac diseases.

Author List

Benjamin IJ, Schneider MD

Author

Ivor J. Benjamin MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Animals, Genetically Modified
Apoptosis
Calcium
Genetic Therapy
Genomics
Heart Failure
Humans
Mitochondria
Nitric Oxide
Oxidative Stress
Protein Kinases
Signal Transduction
Transcription, Genetic