Epidermal growth factors in the kidney and relationship to hypertension. Am J Physiol Renal Physiol 2013 Jul 01;305(1):F12-20
Date
05/03/2013Pubmed ID
23637204Pubmed Central ID
PMC3725676DOI
10.1152/ajprenal.00112.2013Scopus ID
2-s2.0-84879586136 (requires institutional sign-in at Scopus site) 39 CitationsAbstract
Members of the epidermal growth factor (EGF)-family bind to ErbB (EGFR)-family receptors that play an important role in the regulation of various fundamental cell processes in many organs including the kidney. In this field, most of the research efforts are focused on the role of EGF-ErbB axis in cancer biology. However, many studies indicate that abnormal ErbB-mediated signaling pathways are critical in the development of renal and cardiovascular pathologies. The kidney is a major site of the EGF-family ligands synthesis, and it has been shown to express all four members of the ErbB receptor family. The study of kidney disease regulation by ErbB receptor ligands has expanded considerably in recent years. In vitro and in vivo studies have provided direct evidence of the role of ErbB signaling in the kidney. Recent advances in the understanding of how the proteins in the EGF-family regulate sodium transport and development of hypertension are specifically discussed here. Collectively, these results suggest that EGF-ErbB signaling pathways could be major determinants in the progress of renal lesions, including its effects on the regulation of sodium reabsorption in collecting ducts.
Author List
Staruschenko A, Palygin O, Ilatovskaya DV, Pavlov TSMESH terms used to index this publication - Major topics in bold
AbsorptionAnimals
Blood Pressure
Epidermal Growth Factor
ErbB Receptors
Humans
Hypertension
Kidney
Kidney Tubules, Collecting
Ligands
Risk Factors
Signal Transduction
Sodium
Sodium Chloride, Dietary
