Faculty Collaboration Database

Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome. Leukemia 2004 Apr;18(4):693-702

Date

03/27/2004

Pubmed ID

15044926

DOI

10.1038/sj.leu.2403324

Scopus ID

2-s2.0-2942725639 (requires institutional sign-in at Scopus site)   71 Citations

Abstract

Additional chromosomal aberrations occur frequently in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) of childhood. The treatment outcome of these patients is heterogeneous. This study assessed whether such clinical heterogeneity could be partially explained by the presence and characteristics of additional chromosomal abnormalities. Cytogenetic descriptions were available for 249 of 326 children with Ph+ ALL, diagnosed and treated by 10 different study groups/large single institutions from 1986 to 1996. Secondary aberrations were present in 61% of the cases. Chromosomes 9, 22, 7, 14, and 8 were most frequently abnormal. Most (93%) karyotypes were unbalanced. Three main cytogenetic subgroups were identified: no secondary aberrations, gain of a second Ph and/or >50 chromosomes, or loss of chromosome 7, 7p, and/or 9p, while other secondary aberrations were grouped as combinations of gain and loss or others. Of the three main cytogenetic subgroups, the loss group had the worst event-free survival (P=0.124) and disease-free survival (P=0.013). However, statistical significance was not maintained when adjusted for other prognostic factors and treatment. Karyotypic analysis is valuable in subsets of patients identified by molecular screening, to assess the role of additional chromosomal abnormalities and their correlation with clinical heterogeneity, with possible therapeutic implications.

Author List

Heerema NA, Harbott J, Galimberti S, Camitta BM, Gaynon PS, Janka-Schaub G, Kamps W, Basso G, Pui CH, Schrappe M, Auclerc MF, Carroll AJ, Conter V, Harrison CJ, Pullen J, Raimondi SC, Richards S, Riehm H, Sather HN, Shuster JJ, Silverman LB, Valsecchi MG, Aricò M, Acute Lymphoblastic Leukemia Study Groups, ALL-BFM, CoALL, AIEOP, DCLSG, FRALLE, CCG, DFCI, POG, St Jude, UKALL

MESH terms used to index this publication - Major topics in bold

Child
Chromosome Aberrations
Chromosome Breakage
Chromosome Deletion
Cytogenetic Analysis
Disease-Free Survival
Female
Genetic Heterogeneity
Humans
Likelihood Functions
Male
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Survival Analysis
Treatment Outcome