Faculty Collaboration Database

Reflex ventilatory effects of KCl stimulation of lung receptors with sympathetic afferents. Respir Physiol 1990 Dec;82(3):349-58

Date

12/01/1990

Pubmed ID

1964240

DOI

10.1016/0034-5687(90)90104-7

Scopus ID

2-s2.0-0025687950 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

The purpose of this study was to determine the reflex ventilatory effects produced by lung receptors with sympathetic afferent nerves. Seven dogs were anesthetized with sodium pentobarbital, placed on a ventilator, and vagotomized. The chest was opened through a mid-sternal incision. Diaphragm EMG (D-EMG), right and left triangularis sterni EMG (TS-EMG), systemic arterial blood pressure (BP), and tracheal pressure were recorded before and after the application of 2 M KCl to the right or left lung near the venous hilum. The reflex effects produced by KCl applied to the superior vena cava (SVC) and of mechanical distortion of the lungs were also studied. KCl applied to the right or left lung or right or left lung distortion produced significant increases in peak TS-EMG ipsilateral to the applied stimulus with no significant effects on the contralateral TS-EMG. BP, inspiratory time, expiratory time, or peak D-EMG were not significantly affected, except for a decrease in inspiratory time when KCl was applied to the left lung and a decrease in BP with distortion of the left lung. KCl applied to the SVC produced a significant reflex increase in the right TS-EMG. The primary reflex response to chemical stimulation of lung receptors with sympathetic afferents was an increase in expiratory muscle activity. Additionally, mechanical stimulation may also activate these receptors. Furthermore, receptors which produce similar reflex responses are located on the SVC. That the reflex responses produced by intrathoracic receptors with sympathetic afferents were unilateral suggests that spinal mechanisms are involved.

Author List

Coon RL, Clifford PS, Hopp FA, Zuperku EJ

Author

Edward J. Zuperku PhD, MS Emeritus Professor in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood Pressure
Dogs
Electromyography
Lung
Neurons, Afferent
Potassium Chloride
Pulmonary Circulation
Receptors, Cell Surface
Reflex
Respiration
Respiratory Muscles
Ventilation-Perfusion Ratio