Involvement of microRNA families in cancer. Nucleic Acids Res 2012 Sep 01;40(17):8219-26
Date
06/30/2012Pubmed ID
22743268Pubmed Central ID
PMC3458565DOI
10.1093/nar/gks627Scopus ID
2-s2.0-84866947636 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Collecting representative sets of cancer microRNAs (miRs) from the literature we show that their corresponding families are enriched in sets of highly interacting miR families. Targeting cancer genes on a statistically significant level, such cancer miR families strongly intervene with signaling pathways that harbor numerous cancer genes. Clustering miR family-specific profiles of pathway intervention, we found that different miR families share similar interaction patterns. Resembling corresponding patterns of cancer miRs families, such interaction patterns may indicate a miR family's potential role in cancer. As we find that the number of targeted cancer genes is a naïve proxy for a cancer miR family, we design a simple method to predict candidate miR families based on gene-specific interaction profiles. Assessing the impact of miR families to distinguish between (non-)cancer genes, we predict a set of 84 potential candidate families, including 75% of initially collected cancer miR families. Further confirming their relevance, predicted cancer miR families are significantly indicated in increasing, non-random numbers of tumor types.
Author List
Wuchty S, Arjona D, Bozdag S, Bauer POMESH terms used to index this publication - Major topics in bold
Gene Expression Regulation, NeoplasticGenes, Neoplasm
Humans
MicroRNAs
Neoplasms
Protein Interaction Mapping
RNA, Messenger
Signal Transduction
