Medical College of Wisconsin
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Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012 Apr 24;78(17):1337-45

Date

04/25/2012

Pubmed ID

22529202

Pubmed Central ID

PMC3335452

DOI

10.1212/WNL.0b013e3182535d20

Scopus ID

2-s2.0-84860767840 (requires institutional sign-in at Scopus site)   767 Citations

Abstract

OBJECTIVE: To provide updated evidence-based recommendations for the preventive treatment of migraine headache. The clinical question addressed was: What pharmacologic therapies are proven effective for migraine prevention?

METHODS: The authors analyzed published studies from June 1999 to May 2009 using a structured review process to classify the evidence relative to the efficacy of various medications available in the United States for migraine prevention.

RESULTS AND RECOMMENDATIONS: The author panel reviewed 284 abstracts, which ultimately yielded 29 Class I or Class II articles that are reviewed herein. Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity (Level A). Frovatriptan is effective for prevention of menstrual migraine (Level A). Lamotrigine is ineffective for migraine prevention (Level A).

Author List

Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E, Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society



MESH terms used to index this publication - Major topics in bold

Adrenergic beta-Antagonists
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Anticoagulants
Anticonvulsants
Antidepressive Agents
Benzimidazoles
Biphenyl Compounds
Calcium Channel Blockers
Carbonic Anhydrase Inhibitors
Evidence-Based Medicine
Humans
Migraine Disorders
Neuroprotective Agents
Parasympatholytics
Tetrazoles
Tryptamines