Development of an effective treatment program for childhood acute lymphocytic leukemia: a preliminary report. Med Pediatr Oncol 1976;2(2):157-66
Date
01/01/1976Pubmed ID
822270DOI
10.1002/mpo.2950020205Scopus ID
2-s2.0-0017117049 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The development of an effective therapeutic regimen for acute lymphocytic leukemia (ALL) of childhood is described. By careful surveillance of toxicity and efficacy, positive modifications of treatment strategy were achieved without resorting to classically randomized trails. Teh resultant protocol utilizes vincristine-prednisone induction followed by asparaginase consolidation, intensive intermittent combination maintenance chemotherapy with adriamycin as a major component, and cranial radiotherapy plus intrathecal methotrexate for central nervous system prophylaxis. Preliminary analysis suggests that this regimen may result in prolonged continuous complete remission in at least 80% of children with ALL.
Author List
Furman L, Camitta BM, Jaffe N, Sallan SE, Cassady JR, Traggis D, Leavitt P, Nathan DG, Frei E 3rdMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Antineoplastic Agents
Asparaginase
Child
Child, Preschool
Doxorubicin
Drug Therapy, Combination
Female
Humans
Infant
Leukemia, Lymphoid
Male
Mercaptopurine
Methotrexate
Prednisone
Radiotherapy, High-Energy
Remission, Spontaneous
Vincristine
