Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice. Neurobiol Aging 2003;24(4):615-26
Date
04/26/2003Pubmed ID
12714119DOI
10.1016/s0197-4580(02)00138-0Scopus ID
2-s2.0-0037411533 (requires institutional sign-in at Scopus site) 268 CitationsAbstract
The present study tested whether environmental enrichment can reduce age-related spatial reference memory deficits and alter synaptic protein levels in aged female mice. Female C57BL/6 mice, (4 or 27-28 months), were tested in spatial and cued Morris water maze tasks. Prior to (14 days) and during testing, a subset of aged females was exposed to rodent toys and running wheels for 3h per day. The remaining aged females were group housed but were not exposed to enriching objects. At the conclusion of testing, levels of the presynaptic protein synaptophysin were measured in hippocampus and frontoparietal cortex. Enrichment improved spatial memory acquisition; relative to young controls, aged enriched females performed similarly, whereas aged control females were impaired. Enrichment also accelerated the development of a spatial bias in spatial probe trials. In contrast, the cued task was not significantly affected by enrichment. Hippocampal and cortical synaptophysin levels were increased in aged enriched females relative to young and aged controls. These data suggest that environmental enrichment can be a potent cognitive enhancer for aged females and suggests a potential neurobiological mechanism of this effect.
Author List
Frick KM, Fernandez SMAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AgingAnimals
Brain
Environment
Female
Maze Learning
Memory
Mice
Mice, Inbred C57BL
Synaptophysin
