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Karyn Frick BA,MA,PhD

Professor

Institution: University of Wisconsin - Milwaukee
Department: Psychology

image of /images/ORCIDiD_icon16x16.png https://orcid.org/0000-0002-4237-0208

Member of the Neuroscience Research Center

I am willing to collaborate on research projects.

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Publications (108)

Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief. (Frick KM, Fleischer AW, Schwabe MR, Abdelazim FA, Sem DS, Donaldson WA) Horm Behav 2025 Jun 06;173:105773 PMID: 40482564 SCOPUS ID: 2-s2.0-105007136827 06/08/2025

The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model. (Schwabe MR, Fleischer AW, Kuehn RK, Chaudhury S, York JM, Sem DS, Donaldson WA, LaDu MJ, Frick KM) Front Aging Neurosci 2024;16:1477045 PMID: 39629477 PMCID: PMC11613887 SCOPUS ID: 2-s2.0-85211623056 12/04/2024 3 Citations

Editorial: Cortico-hippocampal interactions during learning and memory. (Todd TP, Bravo-Rivera C, Frick KM, Furtak SC) Front Behav Neurosci 2024;18:1454782 PMID: 39193192 PMCID: PMC11347408 SCOPUS ID: 2-s2.0-85202487001 08/28/2024

Astrocytic glutamate transport is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice. (Taxier LR, Pillerová M, Branyan TE, Sohrabji F, Frick KM) Horm Behav 2024 Sep;165:105618 PMID: 39180889 PMCID: PMC11498968 SCOPUS ID: 2-s2.0-85201779841 08/26/2024 1 Citation

G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice. (Machado GDB, Schnitzler AL, Fleischer AW, Beamish SB, Frick KM) Horm Behav 2024 May;161:105516 PMID: 38428223 PMCID: PMC11065565 SCOPUS ID: 2-s2.0-85186578446 03/02/2024 1 Citation

TrkB-mediated sustained neuroprotection is sex-specific and Erα-dependent in adult mice following neonatal hypoxia ischemia. (Chanana V, Hackett M, Deveci N, Aycan N, Ozaydin B, Cagatay NS, Hanalioglu D, Kintner DB, Corcoran K, Yapici S, Camci F, Eickhoff J, Frick KM, Ferrazzano P, Levine JE, Cengiz P) Biol Sex Differ 2024 Jan 04;15(1):1 PMID: 38178264 PMCID: PMC10765746 SCOPUS ID: 2-s2.0-85181452626 01/05/2024 3 Citations

TrkB-mediated sustained neuroprotection is sex-specific and ERα dependent in adult mice following neonatal hypoxia ischemia. (Chanana V, Hackett M, Deveci N, Aycan N, Ozaydin B, Cagatay NS, Hanalioglu D, Kintner DB, Corcoran K, Yapici S, Camci F, Eickhoff J, Frick KM, Ferrazano P, Levine JE, Cengiz P) Res Sq 2023 Sep 07 PMID: 37720039 PMCID: PMC10503864 09/18/2023

New perspectives on sex differences in learning and memory. (Fleischer AW, Frick KM) Trends Endocrinol Metab 2023 Sep;34(9):526-538 PMID: 37500421 PMCID: PMC10617789 SCOPUS ID: 2-s2.0-85165648763 07/28/2023 18 Citations

Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation. (Boyd HM, Frick KM, Kwapis JL) J Biol Rhythms 2023 Dec;38(6):537-555 PMID: 37464775 PMCID: PMC10615791 SCOPUS ID: 2-s2.0-85165585430 07/19/2023

Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies. (Pillerová M, Pastorek M, Borbélyová V, Riljak V, Frick KM, Hodosy J, Tóthová L) Physiol Res 2022 Dec 31;71(S2):S187-S202 PMID: 36647907 PMCID: PMC9906660 SCOPUS ID: 2-s2.0-85146326390 01/18/2023 10 Citations

Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice. (Beamish SB, Gross KS, Anderson MM, Helmstetter FJ, Frick KM) Learn Mem 2022 Sep;29(9):302-311 PMID: 36206392 PMCID: PMC9488027 SCOPUS ID: 2-s2.0-85139571787 10/08/2022 4 Citations

Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders. (Pillerová M, Borbélyová V, Pastorek M, Riljak V, Hodosy J, Frick KM, Tóthová L) Front Psychiatry 2022;13:972158 PMID: 36159923 PMCID: PMC9492942 SCOPUS ID: 2-s2.0-85138567241 09/27/2022 11 Citations

APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease. (Taxier LR, Philippi SM, Fleischer AW, York JM, LaDu MJ, Frick KM) Neurobiol Aging 2022 Oct;118:13-24 PMID: 35843109 PMCID: PMC10756028 SCOPUS ID: 2-s2.0-85134325904 07/18/2022 16 Citations

Extracellular matrix metalloproteinase-9 (MMP-9) is required in female mice for 17β-estradiol enhancement of hippocampal memory consolidation. (Gross KS, Lincoln CM, Anderson MM, Geiger GE, Frick KM) Psychoneuroendocrinology 2022 Jul;141:105773 PMID: 35490640 PMCID: PMC9173600 SCOPUS ID: 2-s2.0-85129402953 05/02/2022 5 Citations

A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation. (Beamish SB, Frick KM) Front Behav Neurosci 2021;15:807215 PMID: 35145382 PMCID: PMC8821141 SCOPUS ID: 2-s2.0-85124339452 02/12/2022 7 Citations

Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice. (Belayet JB, Beamish S, Rahaman M, Alanani S, Virdi RS, Frick DN, Rahman AFMT, Ulicki JS, Biswas S, Arnold LA, Roni MSR, Cheng EY, Steeber DA, Frick KM, Hossain MM) J Med Chem 2022 Feb 24;65(4):3388-3403 PMID: 35133171 PMCID: PMC9135144 SCOPUS ID: 2-s2.0-85124901172 02/09/2022 6 Citations

APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer's disease. (Taxier LR, Philippi SM, York JM, LaDu MJ, Frick KM) Horm Behav 2022 Apr;140:105124 PMID: 35101701 PMCID: PMC8976745 SCOPUS ID: 2-s2.0-85123681433 02/02/2022 10 Citations

The detrimental effects of APOE4 on risk for Alzheimer's disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha. (Taxier LR, Philippi SM, York JM, LaDu MJ, Frick KM) Neurobiol Aging 2022 Apr;112:74-86 PMID: 35051676 PMCID: PMC8976726 SCOPUS ID: 2-s2.0-85122971375 01/21/2022 14 Citations

Estradiol effects on spatial memory in women. (Patel SA, Frick KM, Newhouse PA, Astur RS) Behav Brain Res 2022 Jan 24;417:113592 PMID: 34560131 PMCID: PMC8578444 SCOPUS ID: 2-s2.0-85115936612 09/25/2021 22 Citations

Chemogenetic inactivation of the nucleus reuniens impairs object placement memory in female mice. (Schwabe MR, Lincoln CM, Ivers MM, Frick KM) Neurobiol Learn Mem 2021 Nov;185:107521 PMID: 34536525 PMCID: PMC8595750 SCOPUS ID: 2-s2.0-85115003488 09/19/2021 6 Citations

On the role of sex steroids in biological functions by classical and non-classical pathways. An update. (Pillerová M, Borbélyová V, Hodosy J, Riljak V, Renczés E, Frick KM, Tóthová Ľ) Front Neuroendocrinol 2021 Jul;62:100926 PMID: 34089761 PMCID: PMC8523217 SCOPUS ID: 2-s2.0-85107701256 06/06/2021 42 Citations

Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice. (Fleischer AW, Schalk JC, Wetzel EA, Hanson AM, Sem DS, Donaldson WA, Frick KM) Horm Behav 2021 Apr;130:104948 PMID: 33571507 PMCID: PMC8680219 SCOPUS ID: 2-s2.0-85102084141 02/12/2021 18 Citations

17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. (Gross KS, Alf RL, Polzin TR, Frick KM) Psychoneuroendocrinology 2021 Mar;125:105110 PMID: 33352471 PMCID: PMC7904635 SCOPUS ID: 2-s2.0-85098179470 12/23/2020 21 Citations

Oestradiol as a neuromodulator of learning and memory. (Taxier LR, Gross KS, Frick KM) Nat Rev Neurosci 2020 Oct;21(10):535-550 PMID: 32879508 PMCID: PMC8302223 SCOPUS ID: 2-s2.0-85090122273 09/04/2020 138 Citations

It takes a neural village: Circuit-based approaches for estrogenic regulation of episodic memory. (Schwabe MR, Taxier LR, Frick KM) Front Neuroendocrinol 2020 Oct;59:100860 PMID: 32781195 PMCID: PMC7669700 SCOPUS ID: 2-s2.0-85089337893 08/12/2020 9 Citations

Dorsal Hippocampal Actin Polymerization Is Necessary for Activation of G-Protein-Coupled Estrogen Receptor (GPER) to Increase CA1 Dendritic Spine Density and Enhance Memory Consolidation. (Kim J, Schalk JC, Koss WA, Gremminger RL, Taxier LR, Gross KS, Frick KM) J Neurosci 2019 Nov 27;39(48):9598-9610 PMID: 31628182 PMCID: PMC6880457 SCOPUS ID: 2-s2.0-85075814067 10/20/2019 40 Citations

Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism. (Yousuf H, Smies CW, Hafenbreidel M, Tuscher JJ, Fortress AM, Frick KM, Mueller D) Front Behav Neurosci 2019;13:168 PMID: 31417375 PMCID: PMC6684748 SCOPUS ID: 2-s2.0-85072735423 08/17/2019 20 Citations

Dickkopf-1 blocks 17β-estradiol-enhanced object memory consolidation in ovariectomized female mice. (Taxier LR, Philippi SM, Fortress AM, Frick KM) Horm Behav 2019 Aug;114:104545 PMID: 31228421 PMCID: PMC6732224 SCOPUS ID: 2-s2.0-85070374000 06/23/2019 8 Citations

Chemogenetic Suppression of Medial Prefrontal-Dorsal Hippocampal Interactions Prevents Estrogenic Enhancement of Memory Consolidation in Female Mice. (Tuscher JJ, Taxier LR, Schalk JC, Haertel JM, Frick KM) eNeuro 2019;6(2) PMID: 31016230 PMCID: PMC6477593 SCOPUS ID: 2-s2.0-85065038381 04/25/2019 21 Citations

Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition. (Koss WA, Frick KM) Horm Behav 2019 May;111:96-104 PMID: 30653980 PMCID: PMC6527464 SCOPUS ID: 2-s2.0-85060103373 01/18/2019 39 Citations

Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice. (Tuscher JJ, Taxier LR, Fortress AM, Frick KM) Neurobiol Learn Mem 2018 Dec;156:103-116 PMID: 30408525 PMCID: PMC7310386 SCOPUS ID: 2-s2.0-85056743601 11/09/2018 71 Citations

Sex Differences in the Rapid Cell Signaling Mechanisms Underlying the Memory-Enhancing Effects of 17β-Estradiol. (Koss WA, Haertel JM, Philippi SM, Frick KM) eNeuro 2018;5(5) PMID: 30406188 PMCID: PMC6220582 SCOPUS ID: 2-s2.0-85056254216 11/09/2018 57 Citations

Estradiol and hippocampal memory in female and male rodents. (Frick KM, Kim J, Koss WA) Curr Opin Behav Sci 2018 Oct;23:65-74 PMID: 30345337 PMCID: PMC6191066 SCOPUS ID: 2-s2.0-85044923400 10/23/2018 54 Citations

A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. (Hanson AM, Perera KLIS, Kim J, Pandey RK, Sweeney N, Lu X, Imhoff A, Mackinnon AC, Wargolet AJ, Van Hart RM, Frick KM, Donaldson WA, Sem DS) J Med Chem 2018 Jun 14;61(11):4720-4738 PMID: 29741891 PMCID: PMC7217030 SCOPUS ID: 2-s2.0-85046950983 05/10/2018 20 Citations

Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents. (Frick KM, Kim J) Horm Behav 2018 Aug;104:100-110 PMID: 29727606 PMCID: PMC6226372 SCOPUS ID: 2-s2.0-85046681073 05/05/2018 38 Citations

Sex differences in the brain: Implications for behavioral and biomedical research. (Choleris E, Galea LAM, Sohrabji F, Frick KM) Neurosci Biobehav Rev 2018 Feb;85:126-145 PMID: 29287628 PMCID: PMC5751942 SCOPUS ID: 2-s2.0-85039162933 12/31/2017 167 Citations

Distinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice. (Kim J, Frick KM) Psychoneuroendocrinology 2017 Nov;85:110-114 PMID: 28846921 SCOPUS ID: 2-s2.0-85028075586 08/29/2017 34 Citations

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2018 Mar;43(4):781-790 PMID: 28825421 PMCID: PMC5809785 SCOPUS ID: 2-s2.0-85041731033 08/22/2017 35 Citations

Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females. (Frick KM, Tuscher JJ, Koss WA, Kim J, Taxier LR) Physiol Behav 2018 Apr 01;187:57-66 PMID: 28755863 PMCID: PMC5787049 SCOPUS ID: 2-s2.0-85026540702 08/02/2017 51 Citations

Rapid actions of oestrogens and their receptors on memory acquisition and consolidation in females. (Sheppard PAS, Koss WA, Frick KM, Choleris E) J Neuroendocrinol 2018 Feb;30(2) PMID: 28489296 PMCID: PMC6543823 SCOPUS ID: 2-s2.0-85040012971 05/11/2017 44 Citations

Sex differences in hippocampal function. (Koss WA, Frick KM) J Neurosci Res 2017 Jan 02;95(1-2):539-562 PMID: 27870401 SCOPUS ID: 2-s2.0-84994316332 11/22/2016 134 Citations

Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice. (Tuscher JJ, Szinte JS, Starrett JR, Krentzel AA, Fortress AM, Remage-Healey L, Frick KM) Horm Behav 2016 Jul;83:60-67 PMID: 27178577 PMCID: PMC4915975 SCOPUS ID: 2-s2.0-84971432678 05/15/2016 113 Citations

Why estrogens matter for behavior and brain health. (Galea LAM, Frick KM, Hampson E, Sohrabji F, Choleris E) Neurosci Biobehav Rev 2017 May;76(Pt B):363-379 PMID: 27039345 PMCID: PMC5045786 SCOPUS ID: 2-s2.0-84964873228 04/04/2016 133 Citations

17β-Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms. (Kim J, Szinte JS, Boulware MI, Frick KM) J Neurosci 2016 Mar 16;36(11):3309-21 PMID: 26985039 PMCID: PMC4792941 SCOPUS ID: 2-s2.0-84961285265 03/18/2016 117 Citations

Estradiol-Mediated Spine Changes in the Dorsal Hippocampus and Medial Prefrontal Cortex of Ovariectomized Female Mice Depend on ERK and mTOR Activation in the Dorsal Hippocampus. (Tuscher JJ, Luine V, Frankfurt M, Frick KM) J Neurosci 2016 Feb 03;36(5):1483-9 PMID: 26843632 PMCID: PMC4737764 SCOPUS ID: 2-s2.0-84957837222 02/05/2016 120 Citations

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents. (Frick KM, Kim J, Tuscher JJ, Fortress AM) Learn Mem 2015 Sep;22(9):472-93 PMID: 26286657 PMCID: PMC4561402 SCOPUS ID: 2-s2.0-84942106437 08/20/2015 155 Citations

Molecular mechanisms underlying the memory-enhancing effects of estradiol. (Frick KM) Horm Behav 2015 Aug;74:4-18 PMID: 25960081 PMCID: PMC4573242 SCOPUS ID: 2-s2.0-84941747846 05/12/2015 145 Citations

Hippocampal Wnt Signaling: Memory Regulation and Hormone Interactions. (Fortress AM, Frick KM) Neuroscientist 2016 Jun;22(3):278-94 PMID: 25717070 PMCID: PMC7053425 SCOPUS ID: 2-s2.0-84967153588 02/27/2015 65 Citations

Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression. (Benoit JD, Rakic P, Frick KM) Behav Brain Res 2015 Mar 15;281:1-8 PMID: 25496779 PMCID: PMC4305490 SCOPUS ID: 2-s2.0-84920896517 12/17/2014 85 Citations

The mTOR and canonical Wnt signaling pathways mediate the mnemonic effects of progesterone in the dorsal hippocampus. (Fortress AM, Heisler JD, Frick KM) Hippocampus 2015 May;25(5):616-29 PMID: 25483228 SCOPUS ID: 2-s2.0-84928371263 12/09/2014 24 Citations

Regulation of object recognition and object placement by ovarian sex steroid hormones. (Tuscher JJ, Fortress AM, Kim J, Frick KM) Behav Brain Res 2015 May 15;285:140-57 PMID: 25131507 PMCID: PMC4329280 SCOPUS ID: 2-s2.0-84925365895 08/19/2014 103 Citations

17β-Estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle-aged female mice. (Fortress AM, Kim J, Poole RL, Gould TJ, Frick KM) Learn Mem 2014 Sep;21(9):457-67 PMID: 25128537 PMCID: PMC4138358 SCOPUS ID: 2-s2.0-84907750752 08/17/2014 70 Citations

Epigenetic regulation of estrogen-dependent memory. (Fortress AM, Frick KM) Front Neuroendocrinol 2014 Oct;35(4):530-49 PMID: 24878494 PMCID: PMC4174980 SCOPUS ID: 2-s2.0-84908160222 06/01/2014 56 Citations

The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling. (Boulware MI, Heisler JD, Frick KM) J Neurosci 2013 Sep 18;33(38):15184-94 PMID: 24048848 PMCID: PMC6618419 SCOPUS ID: 2-s2.0-84884184598 09/21/2013 171 Citations

Epigenetics, oestradiol and hippocampal memory consolidation. (Frick KM) J Neuroendocrinol 2013 Nov;25(11):1151-62 PMID: 24028406 PMCID: PMC3943552 SCOPUS ID: 2-s2.0-84886707219 09/14/2013 32 Citations

Canonical Wnt signaling is necessary for object recognition memory consolidation. (Fortress AM, Schram SL, Tuscher JJ, Frick KM) J Neurosci 2013 Jul 31;33(31):12619-26 PMID: 23904598 PMCID: PMC6618550 SCOPUS ID: 2-s2.0-84880849552 08/02/2013 97 Citations

17β-estradiol is necessary for extinction of cocaine seeking in female rats. (Twining RC, Tuscher JJ, Doncheck EM, Frick KM, Mueller D) Learn Mem 2013 May 15;20(6):300-6 PMID: 23676202 SCOPUS ID: 2-s2.0-84879316688 05/17/2013 25 Citations

Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus. (Fortress AM, Fan L, Orr PT, Zhao Z, Frick KM) Learn Mem 2013 Feb 19;20(3):147-55 PMID: 23422279 PMCID: PMC3578274 SCOPUS ID: 2-s2.0-84875154348 02/21/2013 126 Citations

Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition. (Zhao Z, Fan L, Fortress AM, Boulware MI, Frick KM) J Neurosci 2012 Feb 15;32(7):2344-51 PMID: 22396409 PMCID: PMC3401048 SCOPUS ID: 2-s2.0-84857090793 03/08/2012 111 Citations

Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline. (Frick KM) Behav Neurosci 2012 Feb;126(1):29-53 PMID: 22289043 PMCID: PMC3401046 SCOPUS ID: 2-s2.0-84861734477 02/01/2012 51 Citations

Introduction to the special section on "Hormones and cognition: perspectives, controversies, and challenges for future research". (Frick KM) Behav Neurosci 2012 Feb;126(1):1-3 PMID: 22289041 SCOPUS ID: 2-s2.0-84861724468 02/01/2012 1 Citation

The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) pathways in the dorsal hippocampus. (Orr PT, Rubin AJ, Fan L, Kent BA, Frick KM) Horm Behav 2012 Apr;61(4):487-95 PMID: 22265866 PMCID: PMC3401043 SCOPUS ID: 2-s2.0-84859100570 01/24/2012 36 Citations

Introduction to the special issue of Neurobiology of Learning and Memory on memory impairment and disease. (Frick KM, Korol DL) Neurobiol Learn Mem 2011 Nov;96(4):505-6 PMID: 21945881 PMCID: PMC4462193 SCOPUS ID: 2-s2.0-82355169493 09/29/2011

The epigenetics of estrogen: epigenetic regulation of hormone-induced memory enhancement. (Frick KM, Zhao Z, Fan L) Epigenetics 2011 Jun;6(6):675-80 PMID: 21593594 PMCID: PMC5360196 SCOPUS ID: 2-s2.0-79958742855 05/20/2011 30 Citations

The impact of age-related ovarian hormone loss on cognitive and neural function. (Boulware MI, Kent BA, Frick KM) Curr Top Behav Neurosci 2012;10:165-84 PMID: 21533680 SCOPUS ID: 2-s2.0-84878873315 05/03/2011 39 Citations

Use it or lose it: environmental enrichment as a means to promote successful cognitive aging. (Frick KM, Benoit JD) ScientificWorldJournal 2010 Jun 16;10:1129-41 PMID: 20563536 PMCID: PMC4462190 SCOPUS ID: 2-s2.0-77955906952 06/22/2010 40 Citations

Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation. (Fan L, Zhao Z, Orr PT, Chambers CH, Lewis MC, Frick KM) J Neurosci 2010 Mar 24;30(12):4390-400 PMID: 20335475 PMCID: PMC2852263 SCOPUS ID: 2-s2.0-77949837819 03/26/2010 133 Citations

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. (Zhao Z, Fan L, Frick KM) Proc Natl Acad Sci U S A 2010 Mar 23;107(12):5605-10 PMID: 20212170 PMCID: PMC2851775 SCOPUS ID: 2-s2.0-77950430993 03/10/2010 190 Citations

A new approach to understanding the molecular mechanisms through which estrogens affect cognition. (Frick KM, Fernandez SM, Harburger LL) Biochim Biophys Acta 2010 Oct;1800(10):1045-55 PMID: 19913600 PMCID: PMC2888644 SCOPUS ID: 2-s2.0-77956173928 11/17/2009 51 Citations

Dorsal hippocampal progesterone infusions enhance object recognition in young female mice. (Orr PT, Lewis MC, Frick KM) Pharmacol Biochem Behav 2009 Aug;93(2):177-82 PMID: 19477194 PMCID: PMC2710613 SCOPUS ID: 2-s2.0-67649271341 05/30/2009 31 Citations

Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. (Harburger LL, Saadi A, Frick KM) Neuroscience 2009 Apr 21;160(1):6-12 PMID: 19223011 PMCID: PMC2668744 SCOPUS ID: 2-s2.0-63649154793 02/19/2009 49 Citations

Sex differences in contextual fear conditioning are associated with differential ventral hippocampal extracellular signal-regulated kinase activation. (Gresack JE, Schafe GE, Orr PT, Frick KM) Neuroscience 2009 Mar 17;159(2):451-67 PMID: 19171181 SCOPUS ID: 2-s2.0-60849094364 01/28/2009 77 Citations

The effects of acute 17beta-estradiol treatment on gene expression in the young female mouse hippocampus. (Pechenino AS, Frick KM) Neurobiol Learn Mem 2009 Mar;91(3):315-22 PMID: 18938255 PMCID: PMC2674265 SCOPUS ID: 2-s2.0-60749100595 10/22/2008 35 Citations

Estrogens and age-related memory decline in rodents: what have we learned and where do we go from here? (Frick KM) Horm Behav 2009 Jan;55(1):2-23 PMID: 18835561 PMCID: PMC2664384 SCOPUS ID: 2-s2.0-58149112403 10/07/2008 186 Citations

Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. (Fernandez SM, Lewis MC, Pechenino AS, Harburger LL, Orr PT, Gresack JE, Schafe GE, Frick KM) J Neurosci 2008 Aug 27;28(35):8660-7 PMID: 18753366 PMCID: PMC2693006 SCOPUS ID: 2-s2.0-52049126390 08/30/2008 248 Citations

Differential effects of acute progesterone administration on spatial and object memory in middle-aged and aged female C57BL/6 mice. (Lewis MC, Orr PT, Frick KM) Horm Behav 2008 Aug;54(3):455-62 PMID: 18585714 PMCID: PMC2586174 SCOPUS ID: 2-s2.0-47549108627 07/01/2008 40 Citations

Estradiol-induced enhancement of object memory consolidation involves NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice. (Lewis MC, Kerr KM, Orr PT, Frick KM) Behav Neurosci 2008 Jun;122(3):716-21 PMID: 18513142 PMCID: PMC2673328 SCOPUS ID: 2-s2.0-44649125951 06/03/2008 96 Citations

Life-long environmental enrichment differentially affects the mnemonic response to estrogen in young, middle-aged, and aged female mice. (Gresack JE, Kerr KM, Frick KM) Neurobiol Learn Mem 2007 Nov;88(4):393-408 PMID: 17869132 PMCID: PMC2098878 SCOPUS ID: 2-s2.0-34848883642 09/18/2007 71 Citations

Age-dependent effects of environmental enrichment on spatial reference memory in male mice. (Harburger LL, Lambert TJ, Frick KM) Behav Brain Res 2007 Dec 11;185(1):43-8 PMID: 17707521 PMCID: PMC2603144 SCOPUS ID: 2-s2.0-35148819275 08/21/2007 95 Citations

Single enrichment variables differentially reduce age-related memory decline in female mice. (Harburger LL, Nzerem CK, Frick KM) Behav Neurosci 2007 Aug;121(4):679-88 PMID: 17663593 SCOPUS ID: 2-s2.0-34548851768 08/01/2007 44 Citations

Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged, female mice. (Gresack JE, Kerr KM, Frick KM) Brain Res 2007 Jul 30;1160:91-101 PMID: 17572392 SCOPUS ID: 2-s2.0-34447335081 06/19/2007 42 Citations

Effects of continuous and intermittent estrogen treatments on memory in aging female mice. (Gresack JE, Frick KM) Brain Res 2006 Oct 18;1115(1):135-47 PMID: 16920082 SCOPUS ID: 2-s2.0-33748926434 08/22/2006 53 Citations

Post-training estrogen enhances spatial and object memory consolidation in female mice. (Gresack JE, Frick KM) Pharmacol Biochem Behav 2006 May;84(1):112-9 PMID: 16759685 SCOPUS ID: 2-s2.0-33745677260 06/09/2006 131 Citations

Effects of estrogen and progesterone on spatial memory consolidation in aged females. (Harburger LL, Bennett JC, Frick KM) Neurobiol Aging 2007 Apr;28(4):602-10 PMID: 16621169 SCOPUS ID: 2-s2.0-33847107723 04/20/2006 81 Citations

Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice. (Bennett JC, McRae PA, Levy LJ, Frick KM) Neurobiol Learn Mem 2006 Mar;85(2):139-52 PMID: 16256380 SCOPUS ID: 2-s2.0-32644469698 11/01/2005 154 Citations

Men and women differ in object memory but not performance of a virtual radial maze. (Levy LJ, Astur RS, Frick KM) Behav Neurosci 2005 Aug;119(4):853-62 PMID: 16187814 SCOPUS ID: 2-s2.0-25444469897 09/29/2005 98 Citations

Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice. (Lambert TJ, Fernandez SM, Frick KM) Neurobiol Learn Mem 2005 May;83(3):206-16 PMID: 15820856 SCOPUS ID: 2-s2.0-16844383069 04/12/2005 162 Citations

Chronic oral estrogen affects memory and neurochemistry in middle-aged female mice. (Fernandez SM, Frick KM) Behav Neurosci 2004 Dec;118(6):1340-51 PMID: 15598143 PMCID: PMC1483220 SCOPUS ID: 2-s2.0-9644295897 12/16/2004 79 Citations

Environmental enrichment reduces the mnemonic and neural benefits of estrogen. (Gresack JE, Frick KM) Neuroscience 2004;128(3):459-71 PMID: 15381276 PMCID: PMC1513274 SCOPUS ID: 2-s2.0-4644261146 09/24/2004 73 Citations

Behavioral training interferes with the ability of gonadal hormones to increase CA1 spine synapse density in ovariectomized female rats. (Frick KM, Fernandez SM, Bennett JC, Prange-Kiel J, MacLusky NJ, Leranth C) Eur J Neurosci 2004 Jun;19(11):3026-32 PMID: 15182310 PMCID: PMC1482789 SCOPUS ID: 2-s2.0-3042608067 06/09/2004 78 Citations

Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learning. (Frick KM, Kim JJ, Baxter MG) Hippocampus 2004;14(2):244-54 PMID: 15098729 SCOPUS ID: 2-s2.0-0842322454 04/22/2004 58 Citations

Low CA1 spine synapse density is further reduced by castration in male non-human primates. (Leranth C, Prange-Kiel J, Frick KM, Horvath TL) Cereb Cortex 2004 May;14(5):503-10 PMID: 15054066 SCOPUS ID: 2-s2.0-2342579510 04/01/2004 73 Citations

Sex differences in the behavioral response to spatial and object novelty in adult C57BL/6 mice. (Frick KM, Gresack JE) Behav Neurosci 2003 Dec;117(6):1283-91 PMID: 14674847 SCOPUS ID: 2-s2.0-0346995345 12/17/2003 176 Citations

Male mice exhibit better spatial working and reference memory than females in a water-escape radial arm maze task. (Gresack JE, Frick KM) Brain Res 2003 Aug 22;982(1):98-107 PMID: 12915244 SCOPUS ID: 2-s2.0-0142107457 08/14/2003 69 Citations

Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice. (Frick KM, Stearns NA, Pan JY, Berger-Sweeney J) Learn Mem 2003;10(3):187-98 PMID: 12773583 PMCID: PMC202309 SCOPUS ID: 2-s2.0-0037642406 05/30/2003 140 Citations

Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice. (Frick KM, Fernandez SM) Neurobiol Aging 2003;24(4):615-26 PMID: 12714119 SCOPUS ID: 2-s2.0-0037411533 04/26/2003 266 Citations

Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice. (Frick KM, Fernandez SM, Bulinski SC) Neuroscience 2002;115(2):547-58 PMID: 12421621 SCOPUS ID: 2-s2.0-0037146708 11/08/2002 190 Citations

Sex differences in neurochemical markers that correlate with behavior in aging mice. (Frick KM, Burlingame LA, Delaney SS, Berger-Sweeney J) Neurobiol Aging 2002;23(1):145-58 PMID: 11755029 SCOPUS ID: 2-s2.0-0036147308 01/05/2002 36 Citations

Spatial reference memory and neocortical neurochemistry vary with the estrous cycle in C57BL/6 mice. (Frick KM, Berger-Sweeney J) Behav Neurosci 2001 Feb;115(1):229-37 PMID: 11256446 SCOPUS ID: 2-s2.0-0035127788 03/21/2001 114 Citations

Cholinergic basal forebrain is critical for social transmission of food preferences. (Berger-Sweeney J, Stearns NA, Frick KM, Beard B, Baxter MG) Hippocampus 2000;10(6):729-38 PMID: 11153718 SCOPUS ID: 2-s2.0-0034501287 01/12/2001 67 Citations

Mice are not little rats: species differences in a one-day water maze task. (Frick KM, Stillner ET, Berger-Sweeney J) Neuroreport 2000 Nov 09;11(16):3461-5 PMID: 11095500 SCOPUS ID: 2-s2.0-0034626938 11/30/2000 142 Citations

Reference memory, anxiety and estrous cyclicity in C57BL/6NIA mice are affected by age and sex. (Frick KM, Burlingame LA, Arters JA, Berger-Sweeney J) Neuroscience 2000;95(1):293-307 PMID: 10619486 SCOPUS ID: 2-s2.0-0032704782 01/05/2000 225 Citations

Presynaptic markers of cholinergic function in the rat brain: relationship with age and cognitive status. (Baxter MG, Frick KM, Price DL, Breckler SJ, Markowska AL, Gorman LK) Neuroscience 1999 Mar;89(3):771-9 PMID: 10199612 SCOPUS ID: 2-s2.0-0032915465 04/13/1999 53 Citations

The effects of nerve growth factor on spatial recent memory in aged rats persist after discontinuation of treatment. (Frick KM, Price DL, Koliatsos VE, Markowska AL) J Neurosci 1997 Apr 01;17(7):2543-50 PMID: 9065514 PMCID: PMC6573502 SCOPUS ID: 2-s2.0-0030910003 04/01/1997 50 Citations

Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity. (Frick KM, Gorman LK, Markowska AL) Behav Brain Res 1996 Oct;80(1-2):99-109 PMID: 8905133 SCOPUS ID: 2-s2.0-0030272535 10/01/1996 27 Citations

Age-related spatial reference and working memory deficits assessed in the water maze. (Frick KM, Baxter MG, Markowska AL, Olton DS, Price DL) Neurobiol Aging 1995;16(2):149-60 PMID: 7777133 SCOPUS ID: 2-s2.0-0028954228 03/01/1995 285 Citations

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. (Baxter MG, Lanthorn TH, Frick KM, Golski S, Wan RQ, Olton DS) Neurobiol Aging 1994;15(2):207-13 PMID: 7838293 SCOPUS ID: 2-s2.0-0028324172 03/01/1994 124 Citations

Acetylcholine release in the hippocampus: effects of cholinergic and GABAergic compounds in the medial septal area. (Gorman LK, Pang K, Frick KM, Givens B, Olton DS) Neurosci Lett 1994 Jan 31;166(2):199-202 PMID: 8177500 SCOPUS ID: 2-s2.0-0027972643 01/31/1994 57 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Karyn Frick BA,MA,PhD

Professor

Publications (108)